DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disp and DISP3

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_065831.1	Gene:	DISP3 / 57540	HGNCID:	29251	Length:	1392	Species:	Homo sapiens

Alignment Length:	1293	Identity:	238/1293 - (18%)
Similarity:	429/1293 - (33%)	Gaps:	466/1293 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IGDSGVFRDYEITNDSASSSLEPT--------RRTEQIEYGHNTTSVDEEEHQQRVQTKKSTWRL 219
            :|..|.:||       .|::.:||        |.|..:|  ....:..|:...||: :|...::
Human   180 LGGPGPYRD-------TSAAQKPTANRSGRLRRETPPLE--DLAANQSEDPRNQRL-SKNGRYQ- 233

  Fly   220 LKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYS------------HFVVQRI---GPNATDSL 269
                .::|.......::.:...|     :.|.:||            |:.::.|   ..:|..::
Human   234 ----PSIPPHAAVAANQSRARRG-----ASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNI 289

  Fly   270 FDLNGLLAMCQLQDQITEVPSYRAFC-EPEMLTTE--------CCRPWSLPNYAAMLANKSSC-F 324
            |....|:.:.:::.:|.:.|.:|.|| :|..:..:        |..|.||..|.......... :
Human   290 FTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYY 354

  Fly   325 DLTTEDVTSLHTLLLGCYEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSND 389
            |...:|:..:...|        :|.|.:          ||           ..:..|......|.
Human   355 DGMGQDLADIRGSL--------ELAMTH----------PE-----------FYWYVDEGLSADNL 390

  Fly   390 SNVYLKYAMIFIPVAQSNRLLPLFH----EWED--VELINELVEVVAMDLGLEN----------- 437
            .:..|:..::|      ...||.::    .||:  .:..:.:|..||| |..::
Human   391 KSSLLRSEILF------GAPLPNYYSVDDRWEEQRAKFQSFVVTYVAM-LAKQSTSKVQVLYGGT 448

  Fly   438 ELFN-ELLLT---DVWLVSLGGTFVMASVWLYTG-SAFITLMSCVAICFSLGLAYFFYAIVLEFE 497
            :||: |:..|   |:.|..:..:.:.|.|::.|. |.|::.....:|..|..:|.|.|.:|...:
Human   449 DLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQ 513

  Fly   498 FFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENI 562
            :...:|.:|..||:|||.||||:|:.                         |...:.|.|..:..
Human   514 YLGILNGVAAFVIVGIGVDDVFVFIN-------------------------TYRQATHLEDPQLR 553

  Fly   563 MALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMER 627
            |..|::.|..:.|.||||||.|:.|:..|.|.|:..||:|...:|...:|.::..:||::.:...
Human   554 MIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSL 618

  Fly   628 LFA-----TRMSCHHPMSIKL-------IHACKKSIN---------------RFCQMFEECIT-- 663
            ..|     .:.|||...|.|.       :.|..:.:.               ...::.||.::
Human   619 YLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSLE 683

  Fly   664 ------------------------------KSIMNYAYLW---------------LLIFGALGAS 683
                                          :.::::..||               :||...:.||
Human   684 LGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSILILSLVFAS 748

  Fly   684 SAVIVFWYPGLQLPEKSHFQ---------------------LFVSKHPFEVYSSLKQQF------ 721
            ........|.|..|: ::.|                     ||..| |..:.::::...
Human   749 RLRPASRAPLLFRPD-TNIQVLLDLKYNLSAEGISCITCSGLFQEK-PHSLQNNIRTSLEKKRRG 811

  Fly   722 ----WFEKPLQAYENF---------KMHMH-------------FVWGVQAVDDGDYTNPNSYGHL 760
                |..:|....::|         |...|             ..|  |||..||...|:...:.
Human   812 SGVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLSLNASLPAPW--QAVSPGDGEVPSFQVYR 874

  Fly   761 HYDNNFN-------------VSSRPAQLWILD------------------------------FCQ 782
            ....||.             .::.|::.|:|.                              |.|
Human   875 APFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQ 939

  Fly   783 SVRQQPFYKETLGMLLPNCFIENLID-YMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQ 846
            | .:.||:.... |..|.|.:.:..| ..|.......:...|.|   ..|.|.|.|.:...|...
Human   940 S-HKPPFHGRVC-MAPPGCLLSSSPDGPTKGFFFVPSEKVPKAR---LSATFGFNPCVNTGCGKP 999

  Fly   847 SI----------------------------------SNMYDTTF--------------------- 856
            ::                                  |.:||::|
Human  1000 AVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSE 1064

  Fly   857 -FRPGVA----------------GPKFAEAPR--------------------------LETEDYL 878
             .:||.|                .|:..|.|.                          .|:..|.
Human  1065 LVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYK 1129

  Fly   879 GMSGNES-AEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQ 942
            |.|..:: ::|....||....::||.   |.:|        :|:.:::.|||.|:.:     |:.
Human  1130 GKSSFQTYSDYLRWESFLQQQLQALP---EGSV--------LRRGFQTCEHWKQIFM-----EIV 1178

  Fly   943 GGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLI 1007
            |           ||..|     ..:.|::...:|.:..||.:||:    :|.|.|||...|.:::
Human  1179 G-----------VQSAL-----CGLVLSLLICVAAVAVFTTHILL----LLPVLLSILGIVCLVV 1223

  Fly  1008 LL----GWQLNILESIAVSTAIGLAVDFSLHYGIHY-----RMSPVKERLAATQ-----FVLSRI 1058
            .:    ||::..:|:|::|..:|.:||:.:|....|     .:.|.:...|.||     ....|.
Human  1224 TIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRH 1288

  Fly  1059 IGPTVM-AATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGP 1115
            :|..:: :|.||.:|...:....|.|:.:.|..:.:...||..|......:||.:..|
Human  1289 VGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	178/955 (19%)
		MMPL	457..627	CDD:304422	48/170 (28%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	38/159 (24%)
DISP3	NP_065831.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..40
		DUF883	102..>170	CDD:295076
		FXMRP1_C_core	148..255	CDD:289039	16/94 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..248		15/82 (18%)
		MMPL	485..615	CDD:304422	44/154 (29%)
		MMPL	<1238..1343	CDD:304422	25/104 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154909
Domainoid	1	1.000	67	1.000	Domainoid score	I9830
eggNOG	1	0.900	-	-		E1_KOG3664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3249
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860