Protein Alignment disp and PTCH1

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_000255.2
• Gene: PTCH1 / 5727
• HGNCID: 9585
• Length: 1447
• Species: Homo sapiens
• Alignment Length: 914
• Identity: 164/914 - (17%)
• Similarity: 301/914 - (32%)
• Gaps: 313/914 - (34%)

  Fly   451 VSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGA 515
            |.|.|..::|          :::.:.:.:|..:|::  |.|...  :..|::.|       |:|.
Human   469 VGLAGVLLVA----------LSVAAGLGLCSLIGIS--FNAATT--QVLPFLAL-------GVGV 512

  Fly   516 DDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLT 580
            |||||        |...||.     |.....:|          .|:.....::...||:.:||::
Human   513 DDVFL--------LAHAFSE-----TGQNKRIP----------FEDRTGECLKRTGASVALTSIS 554

  Fly   581 TAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIH 645
            ...||:.:....|.|::.|.:.|..|||.|:.:::...||.                 :|:.|..
Human   555 NVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAI-----------------LSMDLYR 602

  Fly   646 ACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKH- 709
            ...:.::.||.....|:::.|                                :...|.:...|
Human   603 REDRRLDIFCCFTSPCVSRVI--------------------------------QVEPQAYTDTHD 635

  Fly   710 --------PFEVYS-SLKQQFWFEKPLQAYENFKMHMHFVW---------GVQAV----DDGDYT 752
                    |:..:| :.:.|...:..:|....:..|.|..:         .||.|    |.....
Human   636 NTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQ 700

  Fly   753 NPNSYGHLH------YDNNFNVSSRPAQLWILDFCQSVRQQPFYKET----------LGMLLPNC 801
            :|.|.....      .|::.:....|...|.|.........||..:.          ||:|
Human   701 SPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLL---- 761

  Fly   802 FIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTT----------- 855
               .:..|...|..|.:|.|  |..|....::.|....|:|.   |..|||..|
Human   762 ---GVSLYGTTRVRDGLDLT--DIVPRETREYDFIAAQFKYF---SFYNMYIVTQKADYPNIQHL 818

  Fly   856 ----------------------------FFRPGVAGPKFA-----EAPRLETEDYLGMSGNESAE 887
                                        :||..:.|.:.|     |..::...:|...|.:....
Human   819 LYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLA 883

  Fly   888 Y------------------------STNGSFTPLLVKALVIEFESN--VAYSTIYANIRQ----- 921
            |                        ..:|...|......:..:.||  |||:...||||.
Human   884 YKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEW 948

  Fly   922 FYESVEHWFQMQLKTAPPE----------LQGGWFTSD--------------------------- 949
            .::..::..:.:|:....|          |.|...|||
Human   949 VHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGY 1013

  Fly   950 -LKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVN-----ILISIYAVLTVSLSIFNTVAVLIL 1008
             ..|:.....|.|...:.|.:.:|.:..|...|.:|     |::.:.|::||.|     ..::.|
Human  1014 PFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-----FGMMGL 1073

  Fly  1009 LGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAG 1073
            :|.:|:.:..:.:..::|:.|:|::|..:.: ::.:.::.......|..:..|.:..|.:| |.|
Human  1074 IGIKLSAVPVVILIASVGIGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVST-LLG 1136

  Fly  1074 GIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSKRSSGSSKFY 1138
            .:|:|.:...:           ||.:|:|   ::::|.:.|..:|.:.|...|     |....:.
Human  1137 VLMLAGSEFDF-----------IVRYFFA---VLAILTILGVLNGLVLLPVLL-----SFFGPYP 1182

  Fly  1139 ERKPSQVIASEQLLTPTSS---AIVELANSETHELESLNSNSLIKTISGIESAHALSSLPRDFEH 1200
            |..|:..:  .:|.||:..   ::|..|....|            |.||.:|:        |.|:
Human  1183 EVSPANGL--NRLPTPSPEPPPSVVRFAMPPGH------------THSGSDSS--------DSEY 1225

  Fly  1201 SFQT 1204
            |.||
Human  1226 SSQT 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	141/816 (17%)
		MMPL	457..627	CDD:304422	36/169 (21%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	29/149 (19%)
PTCH1	NP_000255.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		2A060602	43..1206	CDD:273338	152/869 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1189..1234		15/63 (24%)
		PHA03377	<1253..1369	CDD:177614
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1270..1360

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840