Protein Alignment disp and ptchd4

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001025356.1
• Gene: ptchd4 / 564097
• ZFINID: ZDB-GENE-041001-178
• Length: 897
• Species: Danio rerio
• Alignment Length: 1012
• Identity: 185/1012 - (18%)
• Similarity: 348/1012 - (34%)
• Gaps: 300/1012 - (29%)

  Fly   227 PTDGWADMHRRQPIEGFFCDSSPRKEYSH----------FVVQRIGPNATDSLFDLNGLLAMCQL 281
            ||...|.:.|......|..|.|..|.||.          .::.|.|.|             :.:|
Zfish    59 PTHSLAKIERSLANSLFPIDQSKHKLYSDLHTPGRYGRLILLARSGGN-------------ILEL 110

  Fly   282 QDQITEV--------PSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLL 338
            .:|:.:|        .:|:.|            .::..:...:......|.   .:|:.::
Zfish   111 AEQVLQVHKKVLDMRVNYKGF------------NYTFAHLCVLRHRDKRCL---LDDIITI---- 156

  Fly   339 LGCYEYFHDLKM----DNHCNEIPHCRAPEECK--RLNIVFNVLNFLTDFSFIKSNDSNVYLKYA 397
                  |.|:::    ::..:::|........|  |::.:.:.|..:.    :.:|:.:..:|:|
Zfish   157 ------FEDIRLAVLSNSTFSKVPVSYPNTTLKDGRVSFIGHQLGGVA----LPANNRDQQVKFA 211

  Fly   398 MIFIPVAQSNRLLPLFHE-----WED--VELINELVEVVAMDLGLEN----ELFNEL-------- 443
            ...........|.|:..:     ||.  .:|:::|. ..:.:|.:::    .|:.:.
Zfish   212 RAIQITYYLRNLGPVVQDIIAEKWETEFCKLVHQLA-TDSQELHIQSLTSFSLWRDFHKTGVLAK 275

  Fly   444 --LLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAICF----SLGLAYF----FYAIVLEFEF 498
              :|..:.||.|..|...:......|..|:.|:..:.||.    :.|:.:.    |.:.:|...|
Zfish   276 SEVLVSLVLVLLAATISSSMRDCLRGKPFLGLLGVLTICIANVTAAGIFFISDGKFNSTLLGIPF 340

  Fly   499 FPYMNLLAVVVIIGIGADDVFLFLKIWH-----CVLTERFSNR------CTLTTQSQSALPTLEN 552
            |          .:|.|...||..|..|.     ....||.::.      |...|.|...:.....
Zfish   341 F----------AMGHGTKGVFELLAGWRRTRESLPFKERVADAFADVMVCYTMTSSLYIITFGMG 395

  Fly   553 SDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITW 617
            :....::|::...     ..||.|..|......::.|.|.:       :|||.:....|..:...
Zfish   396 ASPFTNIESVKVF-----CQSMCVAVLVNYFYVFSFYGSCL-------VFAGQLEQNRYHSVFCC 448

  Fly   618 LPASVSIMER---LFATRMSCHHPMSIKLIHACKKSINRFCQMF-EECITKSIMN-YAYLWLLIF 677
            ...||..::|   .|.|.||..|.:|..  |......|.|.|.| .|..|:.|.| |...:::|.
Zfish   449 KIPSVEYLDRQPTWFKTMMSDGHDLSTH--HDSVPYQNHFIQHFLREHYTEWITNTYVKPFVVIL 511

  Fly   678 GALGASSAVIVFWYPG-LQLPEKSH-FQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFV 740
            ..:.||     |.:.| ||:.:.|: ..|..|..| .|..:|.||.:|       .|:..    |
Zfish   512 YLIYAS-----FSFMGCLQISDGSNIINLLASNSP-SVSFALTQQKYF-------SNYSP----V 559

  Fly   741 WGVQAVDDGDYTNPNSYGHLH-YDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIE 804
            .|....:..:|.|.....||. ....||..|     |                          |:
Zfish   560 IGFYIYEPIEYWNSTVQEHLKTLGQGFNKIS-----W--------------------------ID 593

  Fly   805 NLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEA 869
            |...::  |.::...||:.|                       ..::..|:|.|    .|::...
Zfish   594 NYFHFL--RVVNISASTKSD-----------------------FISILKTSFLR----SPEYQHF 629

  Fly   870 PRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQL 934
                .:|.:         :|.||:             |.::..|.:|...|...::.|...::..
Zfish   630 ----VDDII---------FSKNGA-------------EYDIIASKMYLVARTTEKTREEVVELLE 668

  Fly   935 KTAPPELQGGWFTSDLKF------YNVQDTLSHDTFVAICLAMAASLAVLLCFT----VNILISI 989
            :..|..|     .:.:||      :...|..| .:.::..|....|:..:|..|    :|.|.:.
Zfish   669 RLRPLSL-----INSIKFIVFNPTFVFMDRYS-SSIISPILTSGFSVLTILILTFFLVINPLGNF 727

  Fly   990 YAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFV 1054
            :.:|||:......:.::.|  |.:: ::||::     |.:.::|::.:.:....:...:.||:..
Zfish   728 WLILTVTSVELGVLGLMTL--WNVD-MDSISI-----LCLIYTLNFAMDHCAPHLYTFVLATEHT 784

  Fly  1055 LSRII-------GPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRV 1112
            .::.|       |..::..|:..:.|       |:|         ::.:.|....|.|..||| .
Zfish   785 RTQCIKISLEEHGAAILQNTSCFVIG-------IMP---------LLFVPSNLTYTLFKCSLL-T 832

  Fly  1113 AG--PQHGFLELKWPLW------SKRSSGSSKFYERK 1141
            ||  ..|.|:.|  |::      ||:.....|..:||
Zfish   833 AGCTVLHCFVIL--PVFLTFFPPSKKRHKKKKRAKRK 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	136/710 (19%)
		MMPL	457..627	CDD:304422	34/188 (18%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	26/155 (17%)
ptchd4	NP_001025356.1	Patched	97..853	CDD:280598	170/958 (18%)
		MMPL	298..449	CDD:304422	32/172 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	856..881		3/12 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840