Protein Alignment disp and ptchd1

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_690754.1
• Gene: ptchd1 / 562268
• ZFINID: ZDB-GENE-061220-1
• Length: 887
• Species: Danio rerio
• Alignment Length: 791
• Identity: 148/791 - (18%)
• Similarity: 241/791 - (30%)
• Gaps: 296/791 - (37%)

  Fly   232 ADMHRRQPIEGFFCDS------SPRKEYSH----------FVVQRIGPNATDSLFDLNGLLAMCQ 280
            |..|....|||...||      |....||.          .|..|.|     |:.|.:.:.::.:
Zfish    57 APKHSLAKIEGNLVDSLFPVNRSKHTLYSDLQTPGRYGRVIVTSRRG-----SVLDPHHVNSVLK 116

  Fly   281 LQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYA----AMLANKSSCFDLTTEDVTSLHTLLLGC 341
            |.:.||::       :..||..         ||.    .:|....||.   .:|:       |..
Zfish   117 LHNTITQI-------QVPMLGF---------NYTFAHLCLLDESKSCI---VDDI-------LRV 155

  Fly   342 YEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDS-NVYLKYAMIFIPVA- 404
            .|.....:..||  .:|..|.|                    ..|..|. ..|:.:.:..:..:
Zfish   156 LEEMRSARASNH--SVPPLRYP--------------------ITKLKDGREAYIGHQLGGVLASG 198

  Fly   405 -----QSNRLLPLFHEWEDVELINELVEVVAMDLGLENELFN------ELLLTDVWLVSLGGTFV 458
                 :|.|.|.|.:..:.|..:||:| ..:.:|....||.|      ||.|......||...|.
Zfish   199 GRDGVRSARALQLTYYLQAVSPLNEVV-AASWELLFCRELENFGKAHPELSLHPFTSSSLQRDFQ 262

  Fly   459 MASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLK 523
            ..|     ..:...|:..:|:|.||.:                                  |...
Zfish   263 RTS-----RVSERPLLFSLAVCLSLAM----------------------------------LCCS 288

  Fly   524 IWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYAS 588
            :..||.|:.:.....|.|.|   |.||.::       .|:.|               |.|.:.::
Zfish   289 MRDCVRTKPWLGLLALVTVS---LATLTSA-------GILNL---------------TGGKYNST 328

  Fly   589 YSSSITAIKCFGIFAGTVVVTNYLLMITW--LPASVSIMERLFATRMSCHHPMSIK-LIHACK-- 648
            |......:...|:| ||     :.::.:|  ......:.||:.|....|..|.:.. .:|...
Zfish   329 YLGIPFVMLGHGLF-GT-----FEMLSSWRRTREDQHVKERVAAVFSDCMLPFTASTALHVVTFG 387

  Fly   649 ---------KSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQL 704
                     :::..|||  ..||: .:.||.|: |..:|     |.::...|    |.......|
Zfish   388 IGASPFTNIEAVRLFCQ--NACIS-VLFNYLYI-LTFYG-----SNLVFAGY----LENNYRHSL 439

  Fly   705 FVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDNNFNVS 769
            |..:.|       |.:...:||  |:..|.|:.|:  ..:|.:.|
Zfish   440 FCRRVP-------KPELLQQKP--AWYRFLMYTHY--NEEATEAG-------------------- 473

  Fly   770 SRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIEN--LIDYMKRRCIDDMDSTRKDRSPCCDAQ 832
                                         |.|..|:  |:.:|||...|.:.:|
Zfish   474 -----------------------------PLCAYESHLLVAFMKRYYCDWITNT----------- 498

  Fly   833 FPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPL 897
                     |..|      :...|:...|:   ||....|:..:...:|...:.|.||
Zfish   499 ---------YVKP------FVVLFYLVYVS---FALMGYLQVSEGSDLSNVVATETST------- 538

  Fly   898 LVKALVIEFESNVAYSTIYANIRQF--YESVEHWFQMQLKTAPPELQG----GWFTSDLKF---Y 953
                 :....:...|.:.|:.:..|  |||:|:|.....:.....::|    .||.|.|.:   .
Zfish   539 -----IAYTRAQQRYFSSYSPVIGFYIYESIEYWNTSVQEDLLEYIKGFERISWFESYLNYLHGL 598

  Fly   954 NVQDTLSHDTF 964
            |:..:||...|
Zfish   599 NITTSLSRSNF 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	112/607 (18%)
ptchd1	XP_690754.1	Patched	92..851	CDD:308203	138/756 (18%)