DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disp and PTCHD3

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001382672.1	Gene:	PTCHD3 / 374308	HGNCID:	24776	Length:	954	Species:	Homo sapiens

Alignment Length:	1070	Identity:	202/1070 - (18%)
Similarity:	350/1070 - (32%)	Gaps:	403/1070 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 LEPTRRTEQIEYGHNTTSVDEEEHQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFC-- 245
            |.|...|..:..|......||||..:...|              |....|...||. ::|.|.
Human   143 LAPLMLTAALGTGFLYLPKDEEEDLEEHYT--------------PVGSPAKAERRF-VQGHFTTN 192

  Fly   246 -----DSSPRKEYSHFVVQRIGPNATDSLFD---------LNGLLAMCQL------QDQITEV-P 289
                 .:|.|...::| |..:..:.:|||.|         |:|.:...::      |.|..:| .
Human   193 DSYRFSASRRSTEANF-VSLLVVSYSDSLLDPATFAEVSKLDGAVQDLRVAREKGSQIQYQQVCA 256

  Fly   290 SYRAFCEPEMLTTECCRPWSLPN---YAAMLANKSSCFDLTTEDVTSL---------HTLLL--- 339
            .|||.|.|             ||   ||..: ||       |.:::|:         |.|.|
Human   257 RYRALCVP-------------PNPILYAWQV-NK-------TLNLSSISFPAYNHGRHPLYLTGF 300

  Fly   340 -GCYEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMIFIPV 403
             |.|.....|.|....     .||    |.:.:::          ::|:.|..         ..|
Human   301 FGGYILGGSLGMGQLL-----LRA----KAMRLLY----------YLKTEDPE---------YDV 337

  Fly   404 AQSNRLLPLFHEWEDVELINEL--VEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYT 466
            .....|..|..::.:::.|..|  :|||.. ..|..:|  |...|.|.::.:   |.:|.:
Human   338 QSKQWLTHLLDQFTNIKNILALKKIEVVHF-TSLSRQL--EFEATSVTVIPV---FHLAYI---- 392

  Fly   467 GSAFITLMSCVAICF------------SLGLAYFFYAIVLEFEFFPYMNLLAVVV-------IIG 512
                :.::..|..||            :.|:...|.|:|..|....::.:..|::       |:|
Human   393 ----LIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVIIVANSPFLILG 453

  Fly   513 IGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVT 577
            :|.||:|:.:..||                     .|....|..|.:.|:.:    .||.|:.:|
Human   454 VGVDDMFIMISAWH---------------------KTNLADDIRERMSNVYS----KAAVSITIT 493

  Fly   578 SLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIK 642
            ::|...|.|....||..:::||.|:.|..::..|...||           .|...|:......:.
Human   494 TITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNIT-----------CFGAFMALDGKREVV 547

  Fly   643 LIHACKK------SINRFCQMFEECITKSIMNYAYLWLLIFGAL----GASSAVIVFWY-----P 692
            .:...||      |..:||     |..             ||::    |.....|..::     |
Human   548 CLCWLKKADPKWPSFKKFC-----CFP-------------FGSVPDEHGTDIHPISLFFRDYFGP 594

  Fly   693 GLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSY 757
            .|...|..:|.:|:  :...:.||:...|..::.|...             ....|..|..|
Human   595 FLTRSESKYFVVFI--YVLYIISSIYGCFHVQEGLDLR-------------NLASDDSYITP--- 641

  Fly   758 GHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNC-----------------FIEN 805
             :.:.:.|:.....|..:.|:     .::..::.:.:...|.||                 :::.
Human   642 -YFNVEENYFSDYGPRVMVIV-----TKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDA 700

  Fly   806 LIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAP 870
            .:.|:|.                 ::|.|.|.:.|...:|..:||.            |.|
Human   701 YVQYLKG-----------------NSQDPNEKNTFMNNIPDFLSNF------------PNF---- 732

  Fly   871 RLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVE-------H 928
                                              :.:.|::.|....:.|.|.::.:       .
Human   733 ----------------------------------QHDINISSSNEIISSRGFIQTTDVSSSAKKK 763

  Fly   929 WFQMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTV-NILISIYAV 992
            ....||:....:.|     ..|..|| |..:..|.:.||           |..|| |:|::..|:
Human   764 ILLFQLRRIAEDCQ-----IPLMVYN-QAFIYFDQYAAI-----------LEDTVRNVLVASAAM 811

  Fly   993 LTVSL--------SIFNTVAV-LILLG-------WQLNILESIAVST---AIGLAVDFSLHYGIH 1038
            ..|||        |::.|.|: .:::|       |::| |:||::..   .||.:.|||:|....
Human   812 FIVSLLLIPYPLCSLWVTFAIGSVIVGVTGFMAFWKVN-LDSISMINLVICIGFSFDFSVHISYA 875

  Fly  1039 YRMS---PVKERLAATQFVL---------SRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFL 1091
            :..|   .|.::.....::|         |.|||..|:||..
Human   876 FVSSSQPSVNQKSVEALYLLGYPVLQSAISTIIGVCVLAAAK----------------------- 917

  Fly  1092 VVVMIVSWFYATFF-LMSLLRVAGPQHGFL 1120
                  ::.:.||| :|.|:.:.|..||.:
Human   918 ------AYIFRTFFKIMFLVMIFGAAHGLI 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	135/757 (18%)
		MMPL	457..627	CDD:304422	39/188 (21%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	40/177 (23%)
PTCHD3	NP_001382672.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930