Protein Alignment disp and Ptch2

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001102445.2
• Gene: Ptch2 / 366452
• RGDID: 1309039
• Length: 1182
• Species: Rattus norvegicus
• Alignment Length: 902
• Identity: 177/902 - (19%)
• Similarity: 294/902 - (32%)
• Gaps: 292/902 - (32%)

  Fly   381 DFSFIKSNDSNVYLKYAMIFIPVAQSNRLLPL-----FHEWEDVELINELVEVVAMDLGLENELF 440
            |..:.:...|.|...:...|:.:||  ..||.     .|.:....|.:.|            :.|
  Rat   340 DIGWSEEQASMVLQAWQRRFVQLAQ--EALPANASQQIHAFSSTTLDDIL------------QAF 390

  Fly   441 NELLLTDVWLVSLGGTFVMASVWLYT-------------GSAFITLMSCVAICFSLGLAYFFYAI 492
            :|:..|.|    :||..:|.:....|             |.|.:.|:: :|:...|||     ..
  Rat   391 SEVSATRV----VGGYLLMLAYACITMLRWDCAQSQGAVGLAGVLLVA-LAVASGLGL-----CA 445

  Fly   493 VLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTE 557
            :|...|......:...:.:|||.||:||        |...|       |::....|..|.
  Rat   446 LLGITFNAATTQVLPFLALGIGVDDIFL--------LAHAF-------TKAPPNTPLPER----- 490

  Fly   558 SLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASV 622
                 |...:|....|:.:||:....||:.:....|.|::.|.:.|..||..|:..::...||.:
  Rat   491 -----MGECLRRTGTSVALTSINNMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVL 550

  Fly   623 SI-MERLFATRMS---C-HHPMSIKLIHACKKS------------INRFCQMFEECITKS----- 665
            |: :.|....|:.   | ..|.|.::|....:.            :....|.|..|...|
  Rat   551 SLDLRRRHRQRLDVLCCFSSPCSAQVIQMLPQELGDRAVPVGIAHLTATVQAFTHCEASSQHVVT 615

  Fly   666 -------------------------------------------------------IMNYAY---- 671
                                                                   ...|.:
  Rat   616 ILPPQAHLLSPTSDPLGSELYSPGGSTRDLLGQEEGTRPKASCRSLLCAHWTLAHFARYQFAPLL 680

  Fly   672 -------LWLLIFGA-LGASSAVIVFWYPGLQLPE------KSHFQLFVSKHPFEVYS-SLKQQF 721
                   |.||.||| ||.|.........||.|.:      |.|..|......|.:|. :|..|.
  Rat   681 LQTQAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQG 745

  Fly   722 WFEKPLQAYENFKMHMHF----------------VW---------GVQAVDDGDYTN----PNSY 757
            .|:........|.:|..|                .|         |:|...|.|:.:    .|||
  Rat   746 GFDYAHSQRALFDLHQRFSSLKAVLPPPAAQAPRTWLHYYRSWLQGIQTAFDQDWASGRITRNSY 810

  Fly   758 ------GHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCID 816
                  |.|.|  ...:.:..|| ..|||.|...::...||  |::.|..|...|..::.
  Rat   811 RNGSEDGALAY--KLLIQTGNAQ-EPLDFNQLTTRKLVDKE--GLIPPELFYMGLTVWVS----- 865

  Fly   817 DMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTT--FFRPGVAGP-KFAEAPRL-----E 873
                  .|......:|..|.|.     .|:.:.:.||||  ..|...|.| :||:.|.|     :
  Rat   866 ------SDPLGLAASQANFYPP-----PPEWLHDKYDTTGENLRIPAAQPLEFAQFPFLLHGLQK 919

  Fly   874 TEDYL-GMSGNESA--EYSTNG-----SFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWF 930
            |.|:: .:.|..:|  |....|     |.:|.|             :...|..:|:.:
  Rat   920 TADFVEAIEGARAACTEAGQAGVHAYPSGSPFL-------------FWEQYLGLRRCF------- 964

  Fly   931 QMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTV 995
                                        |.....:.:|..:..:|.:|..:|..:::.:.|::||
  Rat   965 ----------------------------LLAVCILLLCTFLVCALLLLNPWTAGLIVLVLAMMTV 1001

  Fly   996 SLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIG 1060
            .|     ..::..||.:|:.:..:.:..::|:.|:|::|..:.:..|.....|.|.: .|.:...
  Rat  1002 EL-----FGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTSHGSRNLRAAR-ALEQTFA 1060

  Fly  1061 PTVMAATTTGLAGGIMMASNILPYI--QIGVFLVVVMIVSWFYATFFLMSLLRVAGP 1115
            |....|.:| |.|.:|:|.:...:|  ...|.|.|:.::...:....|..||.:.||
  Rat  1061 PVTDGAVST-LLGLLMLAGSNFDFIIRYFFVVLTVLTLLGLLHGLLLLPVLLSILGP 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	172/886 (19%)
Ptch2	NP_001102445.2	2A060602	12..1142	CDD:273338	177/902 (20%)