DRSC/TRiP Functional Genomics Resources

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Protein Alignment disp and Npc1a

DIOPT Version :9

Sequence 1:NP_524734.2 Gene:disp / 44274 FlyBaseID:FBgn0029088 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster


Alignment Length:1068 Identity:205/1068 - (19%)
Similarity:361/1068 - (33%) Gaps:356/1068 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   222 QAATLPTDGWADMHRRQPIEGFFCDS--SPRKEYSHFVVQRI-----------GPNATDSLFDLN 273
            :..|.|...||..:.:..:|..|.|:  ||.......:::.:           ||.....:||..
  Fly   375 EITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDRE 439

  Fly   274 GLLAMCQLQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLL 338
            .|..:..||:.|.|:.:     ....|...|..|         |::..|..|::...|.|:    
  Fly   440 FLTKVLDLQEGIKEINA-----NGTQLKDICYAP---------LSDDGSEIDVSQCVVQSI---- 486

  Fly   339 LGCYEYFHD--LKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMI-- 399
               :.||.|  .::|:|          :|....|:.:  |:.|.|..      ||.||..|..  
  Fly   487 ---WGYFGDDRERLDDH----------DEDNGFNVTY--LDALYDCI------SNPYLCLAPYGG 530

  Fly   400 ----------FIPVAQ----------SNRLLPLF-----HEWEDVELINEL------VEVVA--- 430
                      |:|...          :|.::..|     |...|:|  |.|      ||.:.   
  Fly   531 PVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLE--NALTWEKKFVEFMTNYT 593

  Fly   431 -------MDL------GLENELFNE------------LLLTDVWLVSLG------GTFVMASVWL 464
                   ||:      .:|:||..|            |::.....:|||      ..|:.:.:.|
  Fly   594 KNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITL 658

  Fly   465 YTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVII--------GIGADDVFLF 521
            ..|...|.|.|.|:   |:|:             |.|:.|.|.::|:        .:|.|::|:.
  Fly   659 GIGGVIIVLASVVS---SVGV-------------FGYIGLPATLIIVEVIPFLVLAVGVDNIFIL 707

  Fly   522 LKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFY 586
            ::                |.|.....|       .|:||..:...:.....||.:|||:.:..|:
  Fly   708 VQ----------------THQRDQRKP-------NETLEQQVGRILGKVGPSMLLTSLSESFCFF 749

  Fly   587 ASYSSSITAIKCFGIFAGTVVVTNYLLMITWL--------------------------PASVSIM 625
            ....|.:.|::.|.::||..::.::||.||..                          |.|::..
  Fly   750 LGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSN 814

  Fly   626 E-RLFATRMSCHHPMSIKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVF 689
            | .|:....|.:.|..:|.|                 :..|:|...:.||..  ::..:..:.:.
  Fly   815 EGLLYKFFSSVYVPFLMKKI-----------------VRASVMVIFFAWLCF--SIAIAPRIDIG 860

  Fly   690 WYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQ-------AYENFKMHMHFVWGVQAVD 747
            ....|.:|:.|    ||    ...:.||.:......|:.       ||.|..       ....|.
  Fly   861 LDQELAMPQDS----FV----LHYFQSLNENLNIGPPVYFVLKGDLAYTNSS-------DQNLVC 910

  Fly   748 DGDYTNPNS-----YGHLHYDNNFNVSSRPAQLWILDF----------CQSVRQQPFYKETLGML 797
            .|.|.|.:|     |....:.|...: :|||..||.|:          |:       |::..|..
  Fly   911 AGQYCNDDSVLTQIYLASRHSNQTYI-ARPASSWIDDYFDWAAAASSCCK-------YRKDSGDF 967

  Fly   798 LP----NCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFR 858
            .|    :|.          ||....:|..:          |.|....:| ||..:.:..|.|..:
  Fly   968 CPHQDTSCL----------RCNITKNSLLR----------PEEKEFVKY-LPFFLKDNPDDTCAK 1011

  Fly   859 PGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFY 923
            .|.|.             |.|     :..||.:.       :.|.||....:||.||..:...::
  Fly  1012 AGHAA-------------YGG-----AVRYSNSH-------ERLNIEASYFMAYHTILKSSADYF 1051

  Fly   924 ESVEHWFQMQLKTAPPELQGGWFTSDLK-----------------FYNVQDTLSHDTFVAICLAM 971
            .::|...::..... ..|||...::.:.                 ||....|:..||.      .
  Fly  1052 LALESARKISANIT-QMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTL------Q 1109

  Fly   972 AASLAVLLCFTVNILI-------SIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAV 1029
            :..::||..|.|..::       ::..|:|:::.:.|...::......||.:..:.:..|:|::|
  Fly  1110 SMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISV 1174

  Fly  1030 DFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVV 1094
            :|..|....:..|....::......||: :|.::.:..|.....||:    :|.:.:..:|.|  
  Fly  1175 EFCSHLVHSFATSKSVSQIDRAADSLSK-MGSSIFSGITLTKFAGIL----VLAFAKSQIFQV-- 1232

  Fly  1095 MIVSWFYATFFLMSLLRVAGPQHGFLEL 1122
                 ||...:|.  :.|.|..||.:.|
  Fly  1233 -----FYFRMYLG--IVVIGAAHGLIFL 1253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dispNP_524734.2 Patched <444..1111 CDD:280598 141/757 (19%)
MMPL 457..627 CDD:304422 41/204 (20%)
TM_PBP1_branched-chain-AA_like 964..>1109 CDD:294309 27/151 (18%)
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023
2A060601 33..1261 CDD:273337 205/1068 (19%)
Sterol-sensing 651..804 CDD:289145 38/191 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45460569
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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