Protein Alignment disp and Npc1a

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Alignment Length: 1068
• Identity: 205/1068 - (19%)
• Similarity: 361/1068 - (33%)
• Gaps: 356/1068 - (33%)

  Fly   222 QAATLPTDGWADMHRRQPIEGFFCDS--SPRKEYSHFVVQRI-----------GPNATDSLFDLN 273
            :..|.|...||..:.:..:|..|.|:  ||.......:::.:           ||.....:||..
  Fly   375 EITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDRE 439

  Fly   274 GLLAMCQLQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLL 338
            .|..:..||:.|.|:.:     ....|...|..|         |::..|..|::...|.|:
  Fly   440 FLTKVLDLQEGIKEINA-----NGTQLKDICYAP---------LSDDGSEIDVSQCVVQSI---- 486

  Fly   339 LGCYEYFHD--LKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMI-- 399
               :.||.|  .::|:|          :|....|:.:  |:.|.|..      ||.||..|..
  Fly   487 ---WGYFGDDRERLDDH----------DEDNGFNVTY--LDALYDCI------SNPYLCLAPYGG 530

  Fly   400 ----------FIPVAQ----------SNRLLPLF-----HEWEDVELINEL------VEVVA--- 430
                      |:|...          :|.::..|     |...|:|  |.|      ||.:.
  Fly   531 PVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLE--NALTWEKKFVEFMTNYT 593

  Fly   431 -------MDL------GLENELFNE------------LLLTDVWLVSLG------GTFVMASVWL 464
                   ||:      .:|:||..|            |::.....:|||      ..|:.:.:.|
  Fly   594 KNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITL 658

  Fly   465 YTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVII--------GIGADDVFLF 521
            ..|...|.|.|.|:   |:|:             |.|:.|.|.::|:        .:|.|::|:.
  Fly   659 GIGGVIIVLASVVS---SVGV-------------FGYIGLPATLIIVEVIPFLVLAVGVDNIFIL 707

  Fly   522 LKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFY 586
            ::                |.|.....|       .|:||..:...:.....||.:|||:.:..|:
  Fly   708 VQ----------------THQRDQRKP-------NETLEQQVGRILGKVGPSMLLTSLSESFCFF 749

  Fly   587 ASYSSSITAIKCFGIFAGTVVVTNYLLMITWL--------------------------PASVSIM 625
            ....|.:.|::.|.::||..::.::||.||..                          |.|::..
  Fly   750 LGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSN 814

  Fly   626 E-RLFATRMSCHHPMSIKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVF 689
            | .|:....|.:.|..:|.|                 :..|:|...:.||..  ::..:..:.:.
  Fly   815 EGLLYKFFSSVYVPFLMKKI-----------------VRASVMVIFFAWLCF--SIAIAPRIDIG 860

  Fly   690 WYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQ-------AYENFKMHMHFVWGVQAVD 747
            ....|.:|:.|    ||    ...:.||.:......|:.       ||.|..       ....|.
  Fly   861 LDQELAMPQDS----FV----LHYFQSLNENLNIGPPVYFVLKGDLAYTNSS-------DQNLVC 910

  Fly   748 DGDYTNPNS-----YGHLHYDNNFNVSSRPAQLWILDF----------CQSVRQQPFYKETLGML 797
            .|.|.|.:|     |....:.|...: :|||..||.|:          |:       |::..|..
  Fly   911 AGQYCNDDSVLTQIYLASRHSNQTYI-ARPASSWIDDYFDWAAAASSCCK-------YRKDSGDF 967

  Fly   798 LP----NCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFR 858
            .|    :|.          ||....:|..:          |.|....:| ||..:.:..|.|..:
  Fly   968 CPHQDTSCL----------RCNITKNSLLR----------PEEKEFVKY-LPFFLKDNPDDTCAK 1011

  Fly   859 PGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFY 923
            .|.|.             |.|     :..||.:.       :.|.||....:||.||..:...::
  Fly  1012 AGHAA-------------YGG-----AVRYSNSH-------ERLNIEASYFMAYHTILKSSADYF 1051

  Fly   924 ESVEHWFQMQLKTAPPELQGGWFTSDLK-----------------FYNVQDTLSHDTFVAICLAM 971
            .::|...::..... ..|||...::.:.                 ||....|:..||.      .
  Fly  1052 LALESARKISANIT-QMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTL------Q 1109

  Fly   972 AASLAVLLCFTVNILI-------SIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAV 1029
            :..::||..|.|..::       ::..|:|:::.:.|...::......||.:..:.:..|:|::|
  Fly  1110 SMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISV 1174

  Fly  1030 DFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVV 1094
            :|..|....:..|....::......||: :|.::.:..|.....||:    :|.:.:..:|.|
  Fly  1175 EFCSHLVHSFATSKSVSQIDRAADSLSK-MGSSIFSGITLTKFAGIL----VLAFAKSQIFQV-- 1232

  Fly  1095 MIVSWFYATFFLMSLLRVAGPQHGFLEL 1122
                 ||...:|.  :.|.|..||.:.|
  Fly  1233 -----FYFRMYLG--IVVIGAAHGLIFL 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	161/871 (18%)
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	205/1068 (19%)