DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disp and Ptchd1

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001178663.1	Gene:	Ptchd1 / 317517	RGDID:	1564527	Length:	888	Species:	Rattus norvegicus

Alignment Length:	950	Identity:	173/950 - (18%)
Similarity:	317/950 - (33%)	Gaps:	294/950 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 TEDVTSLHTLLLGC--------YEYFH--DLKMDNHC--NEIPHCRAPEECKRLNIVFNVLNFLT 380
            |:.:..|||.:...        |.:.|  .|..|..|  ::|.|  ..||.|..... |..||..
  Rat   112 TDLILKLHTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDIVH--VLEELKNARAT-NRTNFAI 173

  Fly   381 DFSFIKSNDSN-VYLKYAMIFIPVAQSNRLLPLFHEWEDVEL------INELVEVVAMDLGLENE 438
            .:......|.. ||..:.:..:.|...:|:    ...|.::|      ||.|.::||       |
  Rat   174 TYPITHLKDGRAVYNGHQLGGVTVHSKDRV----KSAEAIQLTYYLQSINSLNDMVA-------E 227

  Fly   439 LFNELLLTDVWLVSLGGTFVMASVWLYTGS-------------------AFITLMSCVAICFS-- 482
            .:.......|.|.....:.|  .::.||.|                   :.|.:::...:|.|
  Rat   228 RWESSFCDTVKLFQKSNSKV--KIYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQ 290

  Fly   483 ----------------LGLAYFFYAIVLEFEFFPYMNLLAVV--VIIGIGADDVFLFLKIWHCVL 529
                            :.||....|.::......|.:....|  |::|.|....|..|..|.
  Rat   291 DCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWR--- 352

  Fly   530 TERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFY-------A 587
                                     .|...:::...|....|.||...||||  |.|       |
  Rat   353 -------------------------KTREDQHVKERTAEVYADSMLSFSLTT--AMYLVTFGIGA 390

  Fly   588 SYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHACKKSIN 652
            |..::|.|.:.|...:...::.|||.::::..:|:     :|...:..::..||
  Rat   391 SPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSL-----VFTGYIENNYQHSI----------- 439

  Fly   653 RFCQMF--EECITKSIMNYAYLWLLIFG---ALGASSAVIVFWYPGLQLPEKSHFQL-FVSKH-- 709
             ||:..  .|.:.:....|.:|....|.   |.|..:...           :||..: |:.::
  Rat   440 -FCRKVPKPEVLQEKPAWYRFLLTARFSEDTAEGEEANTY-----------ESHLLVCFLKRYYC 492

  Fly   710 ---------PFEV-YSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDN 764
                     ||.| :..:...|.....||..|...:........|.:   :||.    .|..|.|
  Rat   493 DWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTI---EYTT----AHQKYFN 550

  Fly   765 NFNVSSRPAQLWI---LDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRS 826
            |:   |.....:|   :::..|..|:...:.|.|.:..:.| |:.::|:::..: ..|..:|
  Rat   551 NY---SPVIGFYIYESIEYWNSSVQEDVLEYTKGFVRISWF-ESYLNYLRKLNV-STDLPKK--- 607

  Fly   827 PCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTN 891
                                :.::|...:|.:    .|:|:   ..:.:.......|:..:...:
  Rat   608 --------------------NFTDMLRNSFLK----APQFS---HFQEDIIFSKKYNDEVDVVAS 645

  Fly   892 GSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKFYNVQ 956
            ..|  |:.|             |:..|..:.|:.:|...::.:            ||.:||
  Rat   646 RMF--LVAK-------------TMETNREELYDLLETLRRLSV------------TSKVKF---- 679

  Fly   957 DTLSHDTFVAI---CLAMAASL------AVLLCF-----TVNILISIYAVLTVSLSIFNTVAVLI 1007
             .:.:.:||.:   ..::.|.|      |:.|.|     ..:.||:::..|||....|..:..:.
  Rat   680 -IVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMT 743

  Fly  1008 LLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLA 1072
            |  |::. |:.|:|         ..|.|||:|.:......|:.  |||.:....|........:
  Rat   744 L--WKVE-LDCISV---------LCLIYGINYTIDNCAPLLST--FVLGKDFTRTKWVKNALEV- 793

  Fly  1073 GGIMMASNILPYIQIGVF----------------LVVVMIVSWFYATFFLMSLLRVAGPQHGFLE 1121
            .|:.:..:.|.|| :|:|                |.::..|::|:....|..:|....|
  Rat   794 HGVAILQSYLCYI-VGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPP------ 851

  Fly  1122 LKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVE 1161
                  ||:.....|..|.:  :.|...::|...|:.:|:
  Rat   852 ------SKKKRKEKKNPENR--EEIECVEMLDIDSTRVVD 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	133/763 (17%)
		MMPL	457..627	CDD:304422	38/215 (18%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	38/174 (22%)
Ptchd1	NP_001178663.1	Patched	105..851	CDD:280598	164/902 (18%)
Ptchd1	NP_001178663.1	MMPL	292..443	CDD:304422	36/197 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930