Protein Alignment disp and Disp3

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001101462.2
• Gene: Disp3 / 313705
• RGDID: 1305820
• Length: 1351
• Species: Rattus norvegicus
• Alignment Length: 1251
• Identity: 235/1251 - (18%)
• Similarity: 420/1251 - (33%)
• Gaps: 425/1251 - (33%)

  Fly   170 RDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEHQQRVQTKKSTWRLLKQAATLPTDGWADM 234
            ||...|..||:::.|..||......|       :..:|.|.:...|.|               |.
  Rat   175 RDTAATQRSATNTRERRRREAPPPEG-------QVANQSRARRGASRW---------------DY 217

  Fly   235 HRRQPIEGFFCDSSPRKEYSHFVVQRI---GPNATDSLFDLNGLLAMCQLQDQITEVPSYRAFC- 295
            .|...       |:..:.::|:.::.|   ..:|..::|....|:.:.:::.:|.:.|.:|.||
  Rat   218 SRTYV-------SANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCW 275

  Fly   296 EPEMLTTE--------CCRPWSLPNYAAMLANKSSC-FDLTTEDVTSLHTLLLGCYEYFHDLKMD 351
            :|..:..:        |..|.||..|.......... :|...:|:..:...|        :|.|.
  Rat   276 KPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSL--------ELAMT 332

  Fly   352 NHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMIFIPVAQSNRLLPLFH-- 414
            :          ||           ..:..|......|..:..|:..::|      ...||.::
  Rat   333 H----------PE-----------FYWYVDEGLSVDNLKSSLLRSEILF------GAPLPNYYSV 370

  Fly   415 --EWED--VELINELVEVVAMDLGLEN-----------ELFN-ELLLT---DVWLVSLGGTFVMA 460
              .||:  .:..:.:|..||| |..::           :||: |:..|   |:.|..:..:.:.|
  Rat   371 DDRWEEQRAKFQSFVVTYVAM-LAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAA 434

  Fly   461 SVWLYTG-SAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKI 524
            .|::.|. |.|::.....:|..|..:|.|.|.:|...::...:|.:|..||:|||.||||:|:.
  Rat   435 LVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFIN- 498

  Fly   525 WHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASY 589
                                    |...:.|.|..:..|..|::.|..:.|.||||||.|:.|:.
  Rat   499 ------------------------TYRQATHLEDPQLRMIHTIQTAGKATFFTSLTTAAAYAANV 539

  Fly   590 SSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFA-----TRMSCH------------- 636
            .|.|.|:..||:|...:|...:|.::..:||::.:.....|     .:.|||
  Rat   540 FSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALGLWSLYVAPLESSCQSSCHQKCGRKSSLHFPG 604

  Fly   637 --------------------------------HPMSIKL-------IHACK--------KSINRF 654
                                            .|:|::|       :| |:        .|..:.
  Rat   605 DLFTAPERAGCGPAQGPLPYLDDDIPLLNVEDEPVSLELGDVSLVSVH-CEGLQPTPDGNSRGQL 668

  Fly   655 CQMFEECITKSIMNYAY--LWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKHPFEVYSSL 717
            ....:|.:.:.::..|.  .|:::  .|.||..::...:.....|......||......:|...|
  Rat   669 LAQLQELLHRWVLWAAVKSRWVIV--GLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDL 731

  Fly   718 KQQ-------------FWFEKPLQAYENFKMHMH-------FVWGV------------------- 743
            |..             .:.|||.....|.:..:.       ..|..
  Rat   732 KYNLSAEGISCITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRPETTAQESMSTVYISKVK 796

  Fly   744 --------------------QAVDDGD--------YTNP------------NSYGHLH------- 761
                                |||..||        |..|            ::.|.|.
  Rat   797 SKGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGDFTKKLTACMSTVGLLQAASPSRK 861

  Fly   762 ---------------YDNNFNVSSRPAQ-LWILDFCQSVRQQPFYKETLGMLLPNCFIENLID-- 808
                           :|.:|.|:::..| ...|.|.|| .:.||:.. |.:..|.|.:.:..|
  Rat   862 WMVTALACDARRGWKFDFSFYVATKEQQHTRKLYFAQS-HKPPFHGR-LCVAPPGCLLSSSPDGP 924

  Fly   809 -----YMKRRCIDDMDSTRKDRSPCC--DAQFPFEPHIFEYCLPQSISNMYDT---TFFRPGVAG 863
                 |:.           .||.|..  .|.|.|.|.:...|...::..:.||   .|...|:.|
  Rat   925 TKGFFYVP-----------SDRVPKARISATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIG 978

  Fly   864 PKFAEAPRLETEDYL---------------------------GMSGNES-----------AEYST 890
            ....:    :.::::                           .::||..           :.||.
  Rat   979 INRTQ----QMDNHVIGDPGSVIYDSSFDLFKEIGHLCRLCKAIAGNSELVKPGGAQCLPSGYSI 1039

  Fly   891 NGSFTPLL-----------------------VKALVIEFESNVAYSTIYANIRQF-----YESVE 927
            : ||..:|                       ||...:::.|....||.|.....|     |...|
  Rat  1040 S-SFLQMLHPECKELPEPNLLPGQLSHGAVGVKEGRVQWISMAFESTTYKGKSSFQTYSDYLRWE 1103

  Fly   928 HWFQMQLKTAP--PELQGGWFTSD------LKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVN 984
            .:.:.||:|.|  ..|:.|:.|.:      ::...||..|     ..:.|::...:|.:..||.:
  Rat  1104 SFLRQQLQTFPEGSALRRGFQTCEHWKQIFMEIIGVQSAL-----YGLVLSLLICVAAVAVFTTH 1163

  Fly   985 ILISIYAVLTVSLSIFNTVAVLILL----GWQLNILESIAVSTAIGLAVDFSLHYGIHY-----R 1040
            :|:    :|.|.|||...|.:::.:    ||::..:|:|::|..:|.:||:.:|....|     .
  Rat  1164 VLL----LLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGEN 1224

  Fly  1041 MSPVKERLAATQ-----FVLSRIIGPTVM-AATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSW 1099
            :.|.:...|::|     ....|.:|..:: :|.||.:|...:....|.|:.:.|..:.:...||.
  Rat  1225 LPPQQAEDASSQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSI 1289

  Fly  1100 FYATFFLMSLLRVAGP 1115
            .|......:||.:..|
  Rat  1290 LYTLTVSTALLGIMAP 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	178/940 (19%)
		MMPL	457..627	CDD:304422	48/170 (28%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	36/159 (23%)
Disp3	NP_001101462.2	COG1033	<375..>572	CDD:223964	60/222 (27%)
		COG1033	<1130..>1300	CDD:223964	39/178 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930