DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disp and ptch1

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001292471.1	Gene:	ptch1 / 30189	ZFINID:	ZDB-GENE-980526-196	Length:	1475	Species:	Danio rerio

Alignment Length:	1096	Identity:	207/1096 - (18%)
Similarity:	353/1096 - (32%)	Gaps:	350/1096 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 ECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLLLGCY----EYFH---DL----KMDNHCNE 356
            :|  |.|.||     .|.:..||:..       .|..|||    :|.|   :|    ...|...:
Zfish   292 DC--PLSAPN-----KNTTGPFDVAP-------VLTGGCYGLSKKYMHWQEELIVGGTKKNDSGK 342

  Fly   357 IPHCRAPEECKRL---NIVFNVLNFLTDFSFIKSNDSNV----------YLKYAMIFIPVAQSNR 408
            :...:|.:...:|   ..::..|....:.|.|..|:...          |.:.....:||..|.:
Zfish   343 LLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILEAWQRKYSEAVQQSVPVNSSQK 407

  Fly   409 LL--------PLFHEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVSL-------GGTFV 458
            :|        .:...:.||.:|    .:.:..|         |:|....|..|       .|...
Zfish   408 VLTFTTTTLEDILKSFSDVSVI----RIASGYL---------LMLAYACLTMLRWDCAKSQGAVG 459

  Fly   459 MASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLK 523
            :|.|.|.|    :::.:.:.:|..||::  |.|...  :..|::.|       |:|.|||||
Zfish   460 LAGVLLVT----LSVAAGLGLCSLLGIS--FNAATT--QVLPFLAL-------GVGVDDVFL--- 506

  Fly   524 IWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYAS 588
                 |...||.     |.....:|          .|:.....::...||:.:||::...||:.:
Zfish   507 -----LAHAFSE-----TGQNKRIP----------FEDRTGECLKRTGASVALTSISNVTAFFMA 551

  Fly   589 YSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHACKKSINR 653
            ....|.|::.|.:.|..|||.|:.:::...||.                 :|:.|.....:..:.
Zfish   552 ALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAI-----------------LSMDLYRREDRRFDI 599

  Fly   654 FCQMFEECITKSIM---NYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKHPFEVYS 715
            ||.....|..:.|.   ..||          |.|:.....|.    |..|:     |.|.|..::
Zfish   600 FCCFVSPCANRVIQLEPQAAY----------ADSSADSSRYS----PPPSY-----SSHSFAQHT 645

  Fly   716 SLKQQFW------FEKPLQA-YENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDNNFNVSSRPA 773
            .:..|..      ::...|| |...:.|.|......|.:.....|||...:.:...|.:.|:.|.
Zfish   646 QITMQSTVQLRTEYDPRTQAYYTTAEPHSHISVQPYAPNTNPNPNPNRNNNNNNCTNNSSSAVPG 710

  Fly   774 QLWILDFCQS------------------VR--QQPFYKETLGMLLPNCFIENLID---------- 808
            .......|||                  :|  ..|:.:.|........:...|:.
Zfish   711 VATDTASCQSPDGASSTRDLLSQFGDSGIRCLDSPYSRWTFASFAEKHYAPFLLQSTTKVVVIFL 775

  Fly   809 ---------YMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTT--------- 855
                     |...|..|.::.|  |..|....::.|....|.|.   |..|||..|
Zfish   776 FLALLGVSLYGTTRVRDGLELT--DIVPRETGEYDFIRAQFRYF---SFYNMYVVTQRADYAQIQ 835

  Fly   856 ------------------------------FFRPGVAGPKFA-----EAPRLETEDYLGMSGNES 885
                                          :||..:.|.:.|     :|.|:...:|...|.:..
Zfish   836 PQLYELHQRFGSVKYILREENGQLPRMWLHYFRDWLLGLQEAFDKDWQAGRITQGNYRNGSDDGV 900

  Fly   886 AEY-------------------STNGSFTPLLVKALVIEFESN--VAYSTIYANIR--------- 920
            ..|                   |.:|...|......:..:.||  |||:...||||
Zfish   901 LAYKLLVQTGRREKTITRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPHPPEWLHD 965

  Fly   921 ----------------------------------QFYESVE------HWFQMQLKTAPPELQGGW 945
                                              ||.|::|      :.|..|   ..|....|:
Zfish   966 RTDSIPASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNFSRQ---GLPSYPNGY 1027

  Fly   946 FTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLG 1010
               ...|:.....|.|...::|.:.:|.:..|...|.:|...:...||.:||.......::.|:|
Zfish  1028 ---PFLFWEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVLVLSLMTVELFGMMGLIG 1089

  Fly  1011 WQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGI 1075
            .:|:.:..:.:..::|:.|:|::|..:.: ::.:.:|.......|..:..|.:..|.:| |.|.:
Zfish  1090 IKLSAVPVVILIASVGIGVEFTVHVALAF-LTAIGDRNKRAVLALEHMFAPVLDGAFST-LLGVL 1152

  Fly  1076 MMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSKRSSGSSKFYER 1140
            |:|.:...:           ||.:|:|   ::::|.|.|..:|.:.|...|         .::..
Zfish  1153 MLAGSEFDF-----------IVRYFFA---VLAILTVLGVLNGLVLLPVLL---------SYFGP 1194

  Fly  1141 KPSQVIASEQLLTPTSS-----AIVELANSETHELESLNSNSLIK------TISGI 1185
            .|....|..|...||.|     .:|......:|......|:|...      |:|||
Zfish  1195 YPEVSPADGQSRLPTPSPEPPPQVVRFTMRPSHTTPGAGSDSSDSEYGSNTTVSGI 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	155/836 (19%)
		MMPL	457..627	CDD:304422	40/169 (24%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	29/144 (20%)
ptch1	NP_001292471.1	2A060602	30..1220	CDD:273338	199/1064 (19%)
ptch1	NP_001292471.1	Sterol-sensing	451..605	CDD:289145	45/208 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589959
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840