DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment disp and Disp2

DIOPT Version :9

Sequence 1:NP_524734.2 Gene:disp / 44274 FlyBaseID:FBgn0029088 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_733481.1 Gene:Disp2 / 214240 MGIID:2388733 Length:1345 Species:Mus musculus


Alignment Length:1254 Identity:338/1254 - (26%)
Similarity:554/1254 - (44%) Gaps:259/1254 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 YYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETD 76
            |.|::|..|..|:|....:...|.:..|:.:...|||:|.||||.|.|:||.||..|        
Mouse   116 YSHMIADWPVAVIVGCLAFIFLCTLAGLLGSPPLDFSEPLLGFEPRDTEIGRRLEVW-------- 172

  Fly    77 HHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQKMM 141
                                                                             
Mouse   173 ----------------------------------------------------------------- 172

  Fly   142 QFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEH 206
               |.::|.:.|...|....         |.|:.:.|..|:|.|.      .:|....||     
Mouse   173 ---KAMQALTGPKNLLSLSP---------DPEMNSSSLLSTLSPA------AWGRAEESV----- 214

  Fly   207 QQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFV-VQRIGPNATDSLF 270
               |:||:..             |..::...   |.||| ..|.|.::..| |...|    .||:
Mouse   215 ---VRTKRMV-------------GPVEVKEE---ENFFC-GRPEKSHAKLVFVSTSG----GSLW 255

  Fly   271 DLNGLLAMCQL-QDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSL 334
            :|..:.:||:: |:||....|:.|.|: .....|||..|||.||.|:|:|:|||.|.|..|....
Mouse   256 NLQAIHSMCRIEQEQIRSHISFGALCQ-RSAANECCPSWSLGNYLAVLSNRSSCQDTTQADTDRT 319

  Fly   335 HTLLLGCYEYFHDLKMDNHC-----NEIPHC-RAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVY 393
            ..||..|..::|...:...|     ::.|.| :.|.:|...|:|:..|::|.|..|:....::..
Mouse   320 LALLRFCATFYHRGVLVPACVGSSQDKPPFCAQVPAKCTGSNVVYEFLHYLLDRDFLSPQTADYQ 384

  Fly   394 ---LKYAMIFIPVAQSNRLLPLFHE--WEDVELINELVEVVAMDLGLENELFNELLLTDVWLVSL 453
               ||:|::|:|:.:::.||.::.:  .:.:::.:....:..|||||:..|....|..|.....:
Mouse   385 VPSLKFALLFLPIIKTSSLLDIYLDGLGDPIKVSDNYTSISGMDLGLKPRLLKYYLAEDTMYPLI 449

  Fly   454 GGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDV 518
            ....:...:.||..|.|||.||.:.:..||.:|||.|.:.....:||::||.|::::.|:..:..
Mouse   450 ALVVIFFGMSLYLRSLFITFMSLLGVLGSLMVAYFLYHVAFRMAYFPFVNLAALLLLSGVCVNYT 514

  Fly   519 FLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAG 583
            .:||.:|..               |:..:|       :..:.:.:..||.|....:.|:.|||:.
Mouse   515 LIFLDMWRL---------------SRGQVP-------SGGMPHRVGRTMHHFGYLLLVSGLTTSA 557

  Fly   584 AFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMS-------- 640
            |||.||.|.:.|::||.:|.||.|:.:..|.:.||||:|.:.||..|     |..::        
Mouse   558 AFYGSYLSRLPAVRCFALFMGTAVLVHMGLTLLWLPATVVLHERYLA-----HGCVAQAHGQRGG 617

  Fly   641 ---IKLIHACKKSINRFCQ--------MFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGL 694
               ::|:.|..:.|..|.:        :|:..:...::.:.|:|:..|.||.|..|.|....|.|
Mouse   618 SDPLRLLLALHRRIRIFRKIISILSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIGGVSPRL 682

  Fly   695 QLPEKSHF--QLFVSKHPFEVY-SSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNS 756
            |||.....  |.|.|.||||.: :..:|||.|| .|...|...:.:..|||:..||..|..:|.:
Mouse   683 QLPILLPLGGQFFRSSHPFERFDAEYRQQFLFE-DLPPNEGGNLPVVLVWGILPVDTSDPLDPRT 746

  Fly   757 YGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKE------TLGMLLPNCFIENLIDYMKRRCI 815
            ...:..|.:|:.||..||.|:|..|...:.|.|:.:      ||      |.:|.|..:|     
Mouse   747 NSSVVSDPDFSPSSPEAQEWLLALCHGAQNQSFFGDQPEGWPTL------CLVEALQQWM----- 800

  Fly   816 DDMDSTRKDRSPCC-DAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLG 879
            :.....|.....|| .::||:.|.::.:||...                 ...::|. .|.| ||
Mouse   801 ESPSCGRLGPDLCCGQSEFPWAPQLYLHCLKMM-----------------ALEQSPD-GTRD-LG 846

  Fly   880 MSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGG 944
            :      .:.|:|:     :.|||::|::|:.|||.|..:..||..:..|...::..|||.|..|
Mouse   847 L------RFDTHGN-----LAALVLKFQTNLPYSTEYGPVHHFYTEISRWLSTEMSKAPPGLNQG 900

  Fly   945 WFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILL 1009
            ||||:|:.|::|.:||.:..|.:.||:|.:.|.||..|.|:.:|:::|..|:.::..||.:|:||
Mouse   901 WFTSNLELYSLQHSLSTEPAVVLGLALALAFATLLLSTWNVPLSLFSVAAVAGTVLLTVGLLVLL 965

  Fly  1010 GWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGL--- 1071
            .||||..|::.:|.::||:||.:::|.|.|.:.|..:||:...|.|.:|...|.|   |||:   
Mouse   966 EWQLNTAEALFLSASVGLSVDLTINYCISYHLCPHPDRLSRVAFSLRQISRATAM---TTGVLFA 1027

  Fly  1072 AGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPL----WSKRSS 1132
            :|.||:.|.||.|.::|:.:::|..:...:|:||..||....||:....::.||.    |...:.
Mouse  1028 SGVIMLPSTILLYRKLGIIVMMVKFLGCGFASFFFQSLCCFFGPEKNCGQILWPCAHLPWDAGTE 1092

  Fly  1133 -----------GSSKFYERKPSQVIASEQLLTPTSSAIVELANSETHELESLNSNSLIKTISGIE 1186
                       |.|:.||.:|.....|....|.|:::.:....|...|...::..|..     ::
Mouse  1093 DPDEKGRAGPPGFSEHYELQPLARRRSPSFDTSTATSKLSHRPSILSEDLQIHDGSCC-----LQ 1152

  Fly  1187 SAHALSSLPRDFEHSFQTM 1205
            .|.|..| |||.....||:
Mouse  1153 HAQAPVS-PRDLLLDHQTV 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dispNP_524734.2 Patched <444..1111 CDD:280598 209/698 (30%)
MMPL 457..627 CDD:304422 51/169 (30%)
TM_PBP1_branched-chain-AA_like 964..>1109 CDD:294309 53/147 (36%)
Disp2NP_733481.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
MMPL <448..598 CDD:389802 51/171 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1251..1271
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1295..1345
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845376
Domainoid 1 1.000 230 1.000 Domainoid score I2447
eggNOG 1 0.900 - - E1_KOG3664
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 559 1.000 Inparanoid score I1094
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1156918at2759
OrthoFinder 1 1.000 - - FOG0002571
OrthoInspector 1 1.000 - - otm43709
orthoMCL 1 0.900 - - OOG6_105747
Panther 1 1.100 - - LDO PTHR45951
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2285
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.760

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