Protein Alignment disp and Ptchd1

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001087219.1
• Gene: Ptchd1 / 211612
• MGIID: 2685233
• Length: 888
• Species: Mus musculus
• Alignment Length: 950
• Identity: 172/950 - (18%)
• Similarity: 315/950 - (33%)
• Gaps: 294/950 - (30%)

  Fly   328 TEDVTSLHTLLLGC--------YEYFH--DLKMDNHC--NEIPHCRAPEECKRLNIVFNVLNFLT 380
            |:.:..|||.:...        |.:.|  .|..|..|  ::|.|  ..||.|..... |..||..
Mouse   112 TDLILKLHTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDIVH--VLEELKNARAT-NRTNFAI 173

  Fly   381 DFSFIKSNDSN-VYLKYAMIFIPVAQSNRLLPLFHEWEDVEL------INELVEVVAMDLGLENE 438
            .:......|.. ||..:.:..:.|...:|:    ...|.::|      ||.|.::||       |
Mouse   174 TYPITHLKDGRAVYNGHQLGGVTVHSKDRV----KSAEAIQLTYYLQSINSLNDMVA-------E 227

  Fly   439 LFNELLLTDVWLVSLGGTFVMASVWLYTGS-------------------AFITLMSCVAICFS-- 482
            .:.......|.|.....:.|  .::.||.|                   :.|.:::...:|.|
Mouse   228 RWESSFCDTVKLFQKSNSKV--KIYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQ 290

  Fly   483 ----------------LGLAYFFYAIVLEFEFFPYMNLLAVV--VIIGIGADDVFLFLKIWHCVL 529
                            :.||....|.::......|.:....|  |::|.|....|..|..|.
Mouse   291 DCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWR--- 352

  Fly   530 TERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFY-------A 587
                                     .|...:::...|....|.||...||||  |.|       |
Mouse   353 -------------------------KTREDQHVKERTAEVYADSMLSFSLTT--AMYLVTFGIGA 390

  Fly   588 SYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHACKKSIN 652
            |..::|.|.:.|...:...::.|||.::::..:|:     :|...:..::..||
Mouse   391 SPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSL-----VFTGYIENNYQHSI----------- 439

  Fly   653 RFCQMF--EECITKSIMNYAYLWLLIFGALGA---------SSAVIVF-------WYPGLQLPEK 699
             ||:..  .:.:.:....|.:|....|....|         |..::.|       |.....:  |
Mouse   440 -FCRKVPKPDVLQEKPAWYRFLLTARFSEETAEGEEANTYESHLLVCFLKRYYCDWITNTYV--K 501

  Fly   700 SHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDN 764
            ....||     :.:|.|    |.....||..|...:........|.:   :||.    .|..|.|
Mouse   502 PFVVLF-----YLIYIS----FALMGYLQVSEGSDLSNIVATATQTI---EYTT----AHQKYFN 550

  Fly   765 NFNVSSRPAQLWI---LDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRS 826
            |:   |.....:|   :::..|..|:...:.|.|.:..:.| |:.::|:::..: ..|..:|
Mouse   551 NY---SPVIGFYIYESIEYWNSSVQEDVLEYTKGFVRISWF-ESYLNYLRKLNV-STDLPKK--- 607

  Fly   827 PCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTN 891
                                :.::|...:|.:.    |:|:   ..:.:.......|:..:...:
Mouse   608 --------------------NFTDMLRNSFLKT----PQFS---HFQEDIIFSKKYNDEVDVVAS 645

  Fly   892 GSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKFYNVQ 956
            ..|  |:.|             |:..|..:.|:.:|...::.:            ||.:||
Mouse   646 RMF--LVAK-------------TMETNREELYDLLETLRRLSV------------TSKVKF---- 679

  Fly   957 DTLSHDTFVAI---CLAMAASL------AVLLCF-----TVNILISIYAVLTVSLSIFNTVAVLI 1007
             .:.:.:||.:   ..::.|.|      |:.|.|     ..:.||:::..|||....|..:..:.
Mouse   680 -IVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMT 743

  Fly  1008 LLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLA 1072
            |  |::. |:.|:|         ..|.|||:|.:......|:.  |||.:....|........:
Mouse   744 L--WKVE-LDCISV---------LCLIYGINYTIDNCAPLLST--FVLGKDFTRTKWVKNALEV- 793

  Fly  1073 GGIMMASNILPYIQIGVF----------------LVVVMIVSWFYATFFLMSLLRVAGPQHGFLE 1121
            .|:.:..:.|.|| :|:|                |.::..|::|:....|..:|....|
Mouse   794 HGVAILQSYLCYI-VGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPP------ 851

  Fly  1122 LKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVE 1161
                  ||:.....|..|.:  :.|...:::...|:.:|:
Mouse   852 ------SKKKRKEKKNPENR--EEIECVEMVDIDSTRVVD 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	144/822 (18%)
Ptchd1	NP_001087219.1	Patched	105..851	CDD:308203	164/902 (18%)