Protein Alignment disp and Ptch2

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_032984.1
• Gene: Ptch2 / 19207
• MGIID: 1095405
• Length: 1182
• Species: Mus musculus
• Alignment Length: 883
• Identity: 172/883 - (19%)
• Similarity: 283/883 - (32%)
• Gaps: 294/883 - (33%)

  Fly   451 VSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGA 515
            |.|.|..::|          :.:.|.:.:|..||:.  |.|...  :..|::.|       |||.
Mouse   425 VGLAGVLLVA----------LAVASGLGLCALLGIT--FNAATT--QVLPFLAL-------GIGV 468

  Fly   516 DDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLT 580
            ||:||        |...|       |::....|..|.          |...:|....|:.:||:.
Mouse   469 DDIFL--------LAHAF-------TKAPPDTPLPER----------MGECLRSTGTSVALTSVN 508

  Fly   581 TAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSI-MERLFATRMS---C-HHPMS 640
            ...||:.:....|.|::.|.:.|..||..|:..::...||.:|: :.|....|:.   | ..|.|
Mouse   509 NMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFSSPCS 573

  Fly   641 IKLIHACKKS------------INRFCQMFEEC-------------------------------- 661
            .::|....:.            :....|.|..|
Mouse   574 AQVIQMLPQELGDRAVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLLSPASDPLGSELYSP 638

  Fly   662 --ITKSIMN--------------------------YAY-----------LWLLIFGA-LGASSAV 686
              .|:.:::                          |.:           |.||.||| ||.|...
Mouse   639 GGSTRDLLSQEEGTGPQAACRPLLCAHWTLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYG 703

  Fly   687 IVFWYPGLQLPE------KSHFQLFVSKHPFEVYS-SLKQQFWFEKPLQAYENFKMHMHF----- 739
            ......||.|.:      |.|..|......|.:|. :|..|..|:........|.:|..|
Mouse   704 ATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKA 768

  Fly   740 -----------VW---------GVQAVDDGDYTNPNSYGHLHYDNNFNVSSRPAQLWI------- 777
                       .|         |:||..|.|:.:.....| .|.|.....:...:|.|
Mouse   769 VLPPPATQAPRTWLHYYRSWLQGIQAAFDQDWASGRITCH-SYRNGSEDGALAYKLLIQTGNAQE 832

  Fly   778 -LDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFE 841
             |||.|...::...||  |::.|..|...|..::.           .|......:|..|.|.
Mouse   833 PLDFSQLTTRKLVDKE--GLIPPELFYMGLTVWVS-----------SDPLGLAASQANFYPP--- 881

  Fly   842 YCLPQSISNMYDTT--FFRPGVAGP-KFAEAPRL-----ETEDYL-GMSGNESA--EYSTNG--- 892
              .|:.:.:.||||  ..|...|.| :||:.|.|     :|.|:: .:.|..:|  |....|
Mouse   882 --PPEWLHDKYDTTGENLRIPAAQPLEFAQFPFLLHGLQKTADFVEAIEGARAACTEAGQAGVHA 944

  Fly   893 --SFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKFYNV 955
              |.:|.|             :...|..:|:.:
Mouse   945 YPSGSPFL-------------FWEQYLGLRRCF-------------------------------- 964

  Fly   956 QDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIA 1020
               |.....:.:|..:..:|.:|..:|..:::.:.|::||.|     ..::..||.:|:.:..:.
Mouse   965 ---LLAVCILLVCTFLVCALLLLSPWTAGLIVLVLAMMTVEL-----FGIMGFLGIKLSAIPVVI 1021

  Fly  1021 VSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYI 1085
            :..:||:.|:|::|..:.:..|.....|.|.. .|.:...|....|.:| |.|.:|:|.:...:|
Mouse  1022 LVASIGIGVEFTVHVALGFLTSHGSRNLRAAS-ALEQTFAPVTDGAVST-LLGLLMLAGSNFDFI 1084

  Fly  1086 --QIGVFLVVVMIVSWFYATFFLMSLLRVAG--------------------PQHGFLELKWPLWS 1128
              ...|.|.|:.::...:....|..||.:.|                    ||.|.|.     |.
Mouse  1085 IRYFFVVLTVLTLLGLLHGLLLLPVLLSILGPPPQVVQVYKESPQTLNSAAPQRGGLR-----WD 1144

  Fly  1129 KRSSGSSKFYERKPSQVIASEQLLTPTSSAIVELANSE 1166
            :..:....|.....|..:|...  .|...|.|..|:.|
Mouse  1145 RPPTLPQSFARVTTSMTVALHP--PPLPGAYVHPASEE 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	157/806 (19%)
		MMPL	457..627	CDD:304422	38/170 (22%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	32/146 (22%)
Ptch2	NP_032984.1	2A060602	12..1142	CDD:273338	162/836 (19%)
		Sterol-sensing	418..570	CDD:289145	44/190 (23%)
		7TM-7TMR_HD	961..1085	CDD:285000	29/165 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930