DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disp and Ptch1

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_032983.1	Gene:	Ptch1 / 19206	MGIID:	105373	Length:	1434	Species:	Mus musculus

Alignment Length:	894	Identity:	160/894 - (17%)
Similarity:	296/894 - (33%)	Gaps:	287/894 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 VSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGA 515
            |.|.|..::|          :::.:.:.:|..:|::  |.|...  :..|::.|       |:|.
Mouse   455 VGLAGVLLVA----------LSVAAGLGLCSLIGIS--FNAATT--QVLPFLAL-------GVGV 498

  Fly   516 DDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLT 580
            |||||        |...||.     |.....:|          .|:.....::...||:.:||::
Mouse   499 DDVFL--------LAHAFSE-----TGQNKRIP----------FEDRTGECLKRTGASVALTSIS 540

  Fly   581 TAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIH 645
            ...||:.:....|.|::.|.:.|..|||.|:.:::...||.                 :|:.|..
Mouse   541 NVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAI-----------------LSMDLYR 588

  Fly   646 ACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKH- 709
            ...:.::.||.....|:::.|                                :...|.:...|
Mouse   589 REDRRLDIFCCFTSPCVSRVI--------------------------------QVEPQAYTEPHS 621

  Fly   710 --------PFEVYS-SLKQQFWFEKPLQAYENFKMHMHFVW---------GVQAV----DDGDYT 752
                    |:..:| :.:.....:..:|....:..|.|..:         .||.|    |:....
Mouse   622 NTRYSPPPPYTSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDNLSCQ 686

  Fly   753 NPNSYGHLH------YDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLID--- 808
            :|.|.....      .|::.:....|...|.|.........||..:....::.......|:.
Mouse   687 SPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSL 751

  Fly   809 YMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTT------------------ 855
            |...|..|.:|.|  |..|....::.|....|:|.   |..|||..|
Mouse   752 YGTTRVRDGLDLT--DIVPRETREYDFIAAQFKYF---SFYNMYIVTQKADYPNIQHLLYDLHKS 811

  Fly   856 ---------------------FFRPGVAGPKFA-----EAPRLETEDYLGMSGNESAEY------ 888
                                 :||..:.|.:.|     |..|:...:|...|.:....|
Mouse   812 FSNVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQT 876

  Fly   889 ------------------STNGSFTPLLVKALVIEFESN--VAYSTIYANIRQ-----FYESVEH 928
                              ..:|...|......:..:.||  |||:...||||.     .::..::
Mouse   877 GSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADY 941

  Fly   929 WFQMQLKTAPPE----------LQGGWFTSD----------------------------LKFYNV 955
            ..:.:|:....|          |.|...|||                            ..|:..
Mouse   942 MPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQ 1006

  Fly   956 QDTLSHDTFVAICLAMAASLAVLLCFTVN-----ILISIYAVLTVSLSIFNTVAVLILLGWQLNI 1015
            ..:|.|...::|.:.:|.:..|...|.:|     |::.:.|::||.|     ..::.|:|.:|:.
Mouse  1007 YISLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-----FGMMGLIGIKLSA 1066

  Fly  1016 LESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASN 1080
            :..:.:..::|:.|:|::|..:.: ::.:.::.......|..:..|.:..|.:| |.|.:|:|.:
Mouse  1067 VPVVILIASVGIGVEFTVHVALAF-LTAIGDKNHRAMLALEHMFAPVLDGAVST-LLGVLMLAGS 1129

  Fly  1081 ILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSKRSSGSSKFYERKPSQV 1145
            ...:           ||.:|:|   ::::|.|.|..:|.:.|...|         .|:...|...
Mouse  1130 EFDF-----------IVRYFFA---VLAILTVLGVLNGLVLLPVLL---------SFFGPCPEVS 1171

  Fly  1146 IASEQLLTPTSS-----AIVELANSETHELESLNSN----SLIKTISGI 1185
            .|:.....||.|     ::|..|....|.....:|:    |...|:|||
Mouse  1172 PANGLNRLPTPSPEPPPSVVRFAVPPGHTNNGSDSSDSEYSSQTTVSGI 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	139/809 (17%)
		MMPL	457..627	CDD:304422	36/169 (21%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	29/149 (19%)
Ptch1	NP_032983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		2A060602	29..1192	CDD:273338	151/864 (17%)
		Sterol-sensing	448..602	CDD:289145	43/207 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1175..1219		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1257..1348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1368..1396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840