Protein Alignment disp and ptd-2

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_505396.2
• Gene: ptd-2 / 179307
• WormBaseID: WBGene00004211
• Length: 936
• Species: Caenorhabditis elegans
• Alignment Length: 1185
• Identity: 279/1185 - (23%)
• Similarity: 450/1185 - (37%)
• Gaps: 359/1185 - (30%)

  Fly    12 YYHVLARRPYLVVVSIAVYCVACIIVALVLN-KLPDFSDPTLGFETRGTKIGE-RLTAWYNLLQE 74
            |.||:...|.:.:|......|.....||..| ::.|| |||.||||||:.:.. |:|     |:.
 Worm    15 YAHVVIDYPIICIVLTGTISVILTSWALSFNYQVIDF-DPTKGFETRGSPLSSARMT-----LEA 73

  Fly    75 TDHHGALFSNPSDL-WERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQ 138
            ...|.|  ||.:.| |        |.|.  .|..|:|
 Worm    74 MKPHQA--SNENILRW--------YFEQ--DPGRRKR---------------------------- 98

  Fly   139 KMMQFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDE 203
                                              .|.||: :::|:|      |...::...||.
 Worm    99 ----------------------------------YIKNDT-TTTLDP------ITVNYDDYGVDS 122

  Fly   204 EEHQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRIGPNATDS 268
            |.:...::.....:..:.:|  ||.|                    ..||...::.|:  ::.|.
 Worm   123 EPNSSDLEDPCEMYGAIGKA--LPYD--------------------MIEYLGKIMIRV--SSYDD 163

  Fly   269 LFDLNGLLAMCQLQDQITE--------------------VPSYRAFCEPEMLTTECCRPWSLPNY 313
            ||.||.:..:||: |.|.:                    :|.|          |.|      ||
 Worm   164 LFSLNVMKHLCQI-DSIVDNLIIESNYTNPIQALKHSLNIPYY----------TTC------PN- 210

  Fly   314 AAMLANKSSCFDLTTEDVTSLHTLLLGCYEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNF 378
               :..::||..|...|:.:...||..|       |:::         ..|.|...:|     |.
 Worm   211 ---MTTQNSCEALNENDILNFRYLLQKC-------KINS---------TDEVCSAFSI-----NQ 251

  Fly   379 LTDFSFIKSNDSN----VYLKYAMIFIPVAQSNRLLPLFHEWEDVE-------LINEL------- 425
            :.::...|.|.|:    |.||..|                 |...|       ||::|
 Worm   252 VNNWLLTKGNSSDFIIVVVLKVTM-----------------WNGAENRDFYDDLIDKLKDHLERN 299

  Fly   426 --VEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYF 488
              ..:..:.|.::|::|.|.:.||....:.....|.:...:|:.|...|.:..:.:..|.|:|:|
 Worm   300 PHTRMAGIALNMKNKVFQERIQTDSLFAAFSALLVFSCFLIYSRSIIFTCIILMVVTLSSGVAFF 364

  Fly   489 FYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSA-LPTLEN 552
            .|.:||..:|||::|||.||::|.|||||.||.| :::....||.|:   |..:..|. :|....
 Worm   365 IYTVVLGIDFFPFINLLVVVILISIGADDAFLLL-VYYRREVERMSH---LEYKVGSIYIPLYRE 425

  Fly   553 SDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITW 617
            ||   .|...:.|::.|:..||||||||||..|..:.||.:..::|||::|...|..||:|::..
 Worm   426 SD---LLSRSLRLSLHHSLVSMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLI 487

  Fly   618 LPASVSIMERLFATRMS--CHHPMSIKLIHACKKSINRFCQMFEECITKSIMNY---AYLWLLIF 677
            ||.:: |:.|....::|  ...|..|: .|:          .|...||::...:   .::..||.
 Worm   488 LPGAI-ILSRPIRKKLSRGDEEPEKIE-SHS----------YFASKITETTHYFRFGIFICSLIM 540

  Fly   678 GALGASSAVIVFWYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWG 742
            ..|   |..|:|..|||:.|:.:..:|.|..:..|.:.:....|.|    |...:.::..:||:|
 Worm   541 TGL---SLFIIFQNPGLKTPQTNPTKLLVDSNIHEYFDNNVHHFNF----QWQRSARLVKNFVFG 598

  Fly   743 VQAVDD----GDYTNPN-SYGHLHYDNN----------FNVSSRPAQL-------WILDFCQSVR 785
            |.|:.:    ..|..|: ::...||..:          .|:.|:..||       |.....|:..
 Worm   599 VDAIKETSTLSPYNKPSKNFSQAHYSLDTDKLDFYRRIVNLESKKYQLVNYTHVSWADKILQANE 663

  Fly   786 QQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISN 850
                          :||.||      :..|.:...:...|:.....|||
 Worm   664 --------------SCFSEN------KTIIHECILSASVRNKNLIHQFP---------------- 692

  Fly   851 MYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTI 915
              |.....||       :.|.::.:                     |.|....|...||......
 Worm   693 --DDFSVIPG-------DGPFIDQD---------------------LKVVGYFISIPSNQKLQVD 727

  Fly   916 YANIRQFYESVEHWFQMQLKTAPPELQGGWFTSD----------LKFYNVQDTLSHDTFVAICLA 970
            ...|..|::.:|...: |:|.|         |||          .:||::...|...:|.::.::
 Worm   728 TEMIGSFFQEIEESCK-QIKNA---------TSDSVLCLSSTEITRFYDIVSQLRSSSFTSVAIS 782

  Fly   971 MAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHY 1035
            :...|.|::..|..|.:||.:.:.:...|..|||.||||||||:::||..:...|||:.|::|||
 Worm   783 LGICLIVIIACTRVIKLSIISSVIIFFVILWTVASLILLGWQLSVVESTILIITIGLSFDYTLHY 847

  Fly  1036 GIHYRMS---PVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIV 1097
            .:..|.:   |..|:|.:..   |......|..:.|..|||..::.|....:.|||..||::.|.
 Worm   848 VVAIRDTKCVPASEKLTSAH---STAGIACVFGSLTLFLAGCPLLFSQTASFYQIGTMLVILGIT 909

  Fly  1098 SWFYATFFLMSLLRV 1112
            |.|.|:..|.|.|.|
 Worm   910 SLFGASIVLPSFLMV 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	184/707 (26%)
		MMPL	457..627	CDD:304422	63/170 (37%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	49/147 (33%)
ptd-2	NP_505396.2	COG1033	<332..925	CDD:223964	184/698 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160168000
Domainoid	1	1.000	117	1.000	Domainoid score	I3704
eggNOG	1	0.900	-	-		E1_KOG3664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14133
Inparanoid	1	1.050	260	1.000	Inparanoid score	I1916
Isobase	1	0.950	-	0	Normalized mean entropy	S6166
OMA	1	1.010	-	-		QHG49175
OrthoDB	1	1.010	-	-		D1156918at2759
OrthoFinder	1	1.000	-	-		FOG0002571
OrthoInspector	1	1.000	-	-		otm14667
orthoMCL	1	0.900	-	-		OOG6_105747
Panther	1	1.100	-	-	LDO	PTHR45951
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3249
SonicParanoid	1	1.000	-	-		X2285
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790