Protein Alignment disp and PTCHD1

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_775766.2
• Gene: PTCHD1 / 139411
• HGNCID: 26392
• Length: 888
• Species: Homo sapiens
• Alignment Length: 881
• Identity: 155/881 - (17%)
• Similarity: 281/881 - (31%)
• Gaps: 288/881 - (32%)

  Fly   365 ECKRLNIVFNVLNFLTDF--------------SFIKSNDSNVYLKYAMIFIPVAQSNRLLPLFHE 415
            |..:|......:|.|.|.              .|.|||.......|.        |:.|...|.:
Human   207 EAIQLTYYLQSINSLNDMVAERWESSFCDTVRLFQKSNSKVKMYPYT--------SSSLREDFQK 263

  Fly   416 WEDVE---LINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCV 477
            ...|.   |:..|:.||.|.:...:  ..:.:.:..||..||  .|..|:...|.:..|.|....
Human   264 TSRVSERYLVTSLILVVTMAILCCS--MQDCVRSKPWLGLLG--LVTISLATLTAAGIINLTGGK 324

  Fly   478 AICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQ 542
            .....||:.:                     |::|.|....|..|..|.....::.....|....
Human   325 YNSTFLGVPF---------------------VMLGHGLYGTFEMLSSWRKTREDQHVKERTAAVY 368

  Fly   543 SQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIF----- 602
            :.|.|        :.||...|.|......||.| |::..|..|..:        .|..||
Human   369 ADSML--------SFSLTTAMYLVTFGIGASPF-TNIEAARIFCCN--------SCIAIFFNYLY 416

  Fly   603 -----AGTVVVTNYL-------LMITWLPASVSIMER------LFATRMS--------CHHPMSI 641
                 ..::|.|.|:       :....:|...::.|:      |...|.|        .:...|.
Human   417 VLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYESH 481

  Fly   642 KLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFV 706
            .|:...|:   .:|........|..:...||..:.|..:|.           ||:.|.|.....|
Human   482 LLVCFLKR---YYCDWITNTYVKPFVVLFYLIYISFALMGY-----------LQVSEGSDLSNIV 532

  Fly   707 SKHPFEVYSSLKQQFWFE--KPL---QAYENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDNNF 766
            :.....:..:..||.:|.  .|:   ..||:.:     .|.....:|
Human   533 ATATQTIEYTTAQQKYFSNYSPVIGFYIYESIE-----YWNTSVQED------------------ 574

  Fly   767 NVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRSPCCDA 831
                      :|::            |.|.:..:.| |:.::|:::..:    ||.
Human   575 ----------VLEY------------TKGFVRISWF-ESYLNYLRKLNV----STG--------- 603

  Fly   832 QFPFEPHIFEYCLP-QSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFT 895
                        || ::.::|...:|.:    .|:|:   ..:.:.......|:..:...:..|
Human   604 ------------LPKKNFTDMLRNSFLK----APQFS---HFQEDIIFSKKYNDEVDVVASRMF- 648

  Fly   896 PLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKFYNVQDTLS 960
             |:.|             |:..|..:.|:.:|...::.:            ||.:||     .:.
Human   649 -LVAK-------------TMETNREELYDLLETLRRLSV------------TSKVKF-----IVF 682

  Fly   961 HDTFVAI---CLAMAASL------AVLLCF-----TVNILISIYAVLTVSLSIFNTVAVLILLGW 1011
            :.:||.:   ..::.|.|      |:.|.|     ..:.||:::..|||....|..:..:.|  |
Human   683 NPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTL--W 745

  Fly  1012 QLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSR-------------IIGPTV 1063
            ::. |:.|:|         ..|.|||:|.:......|:.  |||.:             :.|..:
Human   746 KVE-LDCISV---------LCLIYGINYTIDNCAPMLST--FVLGKDFTRTKWVKNALEVHGVAI 798

  Fly  1064 MAATTTGLAGGIMMA---SNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWP 1125
            :.:....:.|.|.:|   ||:...:...:||:.  .|::|:....|..:|....|
Human   799 LQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIA--FVTFFHCFAILPVILTFLPP---------- 851

  Fly  1126 LWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVE 1161
              ||:.....|..|.:  :.|...:::...|:.:|:
Human   852 --SKKKRKEKKNPENR--EEIECVEMVDIDSTRVVD 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	127/733 (17%)
		MMPL	457..627	CDD:304422	33/186 (18%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	38/174 (22%)
PTCHD1	NP_775766.2	Patched	105..851	CDD:355433	147/833 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840