Protein Alignment disp and disp3

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_021334179.1
• Gene: disp3 / 100535855
• ZFINID: ZDB-GENE-081104-407
• Length: 1319
• Species: Danio rerio
• Alignment Length: 1289
• Identity: 234/1289 - (18%)
• Similarity: 410/1289 - (31%)
• Gaps: 455/1289 - (35%)

  Fly   106 NHRRRKNKHKNRNKNKRRKEQ------NQSSHEHHDVAQKMMQFKKRLKATSSPSPNLGFDTWIG 164
            |..|:....||:...:|.|:.      |.|..|.|......:...:|.         .|: .::.
Zfish   167 NDNRQFGNEKNKEMKEREKDSSISATLNSSDAEDHKKPDSPLMRTRRF---------AGY-PYLQ 221

  Fly   165 DSGVFR---DYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEHQQRVQTKKSTWRLLKQAATL 226
            ...::|   .:....|..::...|.|.       |....| |....|..|.::..|:
Zfish   222 TQALWRIELVFVAQGDKDNNIFTPDRL-------HTIHHV-ERVLMQHPQFQQFCWK-------- 270

  Fly   227 PTDGWADMHRRQPIEGFFCDSSPRKEYSH-FVVQRIGPNATD----SLFDLNGLLAMCQLQDQIT 286
            |.:...|:    |:...|| |.|....|: |..:|.|....|    .|.|::|.|::.     ||
Zfish   271 PLEALQDL----PLGPSFC-SPPSSVLSYLFPSERAGKIYYDGMGPDLADIHGALSLA-----IT 325

  Fly   287 EVPSYRAFCE----PEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLLLGCYEYFHD 347
            . |.:..:.:    |:.|.:...|  |..::.|.|.:                         |:.
Zfish   326 H-PQFYWYVDESLTPDKLQSSLLR--SEIHFGAPLPS-------------------------FYS 362

  Fly   348 LKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMIFIPVAQSNRLLPL 412
            |:           ..|.|.:||     ..:|:..::.|.:..|...:|..
Zfish   363 LQ-----------DRPLEQRRL-----FRDFVVQYAGILAQQSTSKVKVL--------------- 396

  Fly   413 FHEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTG-SAFITLMSC 476
               :...||.::.|          .:.||    :|:.|....|..:...|::.|. |.|:|....
Zfish   397 ---YGGTELFDDEV----------RKTFN----SDMLLALFSGGCITVLVYVLTSFSVFLTFFGL 444

  Fly   477 VAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTT 541
            .:|..|..:|.|.|.:|...::...:|.:|..||||||.||||:|:.
Zfish   445 ASIGLSCLVALFLYHVVFGVKYLGILNGVAAFVIIGIGVDDVFVFIS------------------ 491

  Fly   542 QSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTV 606
                   |...|.|.......|..||:.|..:.|:||.|||.|:.|:..|.|.|:..||:|...:
Zfish   492 -------TFRQSVHLTCPMQRMISTMKTAGRATFLTSFTTAAAYAANTFSQIPAVHDFGLFMSLI 549

  Fly   607 VVTNYLLMITWLPASVSIMERLFATR--------------------------------------- 632
            |...:|.:...:||::.|.....|.|
Zfish   550 VSCCWLWVSVLMPAALCIWSSCGAARANSCPRWWTTLTKLSSSPGPLSDDDDVALITVEMEPGVY 614

  Fly   633 ----------MSCHHPMS------IKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGAL- 680
                      :|...|:|      :.::.|..:.:.| |.:.|..:.|.........:::.|::
Zfish   615 DSEPDAALLSLSTEAPLSASTEGNVGVVSAHIQRLLR-CWVAEPVVEKRKTIIGVYAVVLLGSVW 678

  Fly   681 ------GASSAVIVFWYPG--------------------------LQLPEKSHFQL-FVS----K 708
                  .||.|.::|....                          ::.|...|... |.|    .
Zfish   679 CCCLLRPASHAPVLFHRDTNLQRLLDMRSNLSAQGISCHMCSGVFMERPHNLHSTADFTSSTSGN 743

  Fly   709 HP----------------------FEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDY 751
            ||                      ..|| ..|.:.....||..| :....:...|...:...||.
Zfish   744 HPTIPSNQSKPASNSSAQTLAGGLLTVY-VFKLEMGSAVPLYRY-SLSASVPAPWQASSAAHGDV 806

  Fly   752 TNPNSYGHLHYDNNFNVS--------SRP-----------AQLWILDF---CQSVRQQP-----F 789
            .:..:|...|.:.:..:|        .||           ::.||.:|   ..||.||.     |
Zfish   807 PSFQAYSSPHSNFSTRISVCVSHAYHPRPRWMLTLRSCDGSRRWIAEFEFYVASVEQQRSRKLYF 871

  Fly   790 YKETLGML-------LPNCF--------------------------------------------I 803
            .:.|:...       .|.|.                                            :
Zfish   872 AQHTISPYPSRVCEGPPGCVFSSGPDGPTQGSFYAPLPAAPAQVKISRTSGFNPCSGGKCGKPAV 936

  Fly   804 ENLID------------------YMKRRCIDDMDSTRKDRSPCCDAQFPFE-----PHIFEYCLP 845
            ..|:|                  .:....|.|:.:...|:.        |:     .|:.:.|..
Zfish   937 RPLVDTGAMVFVVFGILGVNRTQRLDNHVIGDLGNVIYDQD--------FDVFNEIGHLCKLCKV 993

  Fly   846 QSISNMYDTTFFRPGVA-----GPKFAE-APRLETEDY----------------LGMSGN----- 883
            .|.    :|...:||.|     |..... .|.|..|.:                :|:.|.
Zfish   994 ISA----NTNLVKPGGAQCLPSGNSLTSILPLLHPECHSLPEPNLLPGQLSHGAVGLQGGRVHWI 1054

  Fly   884 ----ESAEYSTNGSFTPLLVKALVIEFES----NVAYSTIYANIRQFYESVEHWFQMQLKTAPPE 940
                ||..|....||.   ..|..:::||    .:|.....:.:|:.:::.:||.|:.:     |
Zfish  1055 SMAFESTTYKGKSSFQ---THADFLQWESFLQKQLASLPASSALRRGFQTCQHWKQIFM-----E 1111

  Fly   941 LQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAV 1005
            :.|           |:..|     .::.|::|..:|.:..||.:.|:.:..:|::...:...|||
Zfish  1112 IIG-----------VESAL-----YSLLLSLAICIASVAVFTAHPLLLLPILLSILGMVCLVVAV 1160

  Fly  1006 LILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMS---------PVKERLAATQFVLSRIIGP 1061
            :..|||::..:|:|::|..:|.:||:.||....|.::         |..:|...|....:.:...
Zfish  1161 MYWLGWEMGAVEAISLSILVGSSVDYCLHLVEGYLLAGDTETSGLDPSIKRQIRTLEAANHVGVA 1225

  Fly  1062 TVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGP 1115
            .|.:|.||.::...:....|:|:.:.|..:.:...:|..:......:||...||
Zfish  1226 IVSSAVTTVISTIPLFFCVIVPFAKFGQIVAINTAISIAFTLTVTTALLAAMGP 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	169/927 (18%)
		MMPL	457..627	CDD:304422	50/170 (29%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	33/153 (22%)
disp3	XP_021334179.1	Patched	226..>602	CDD:330476	105/502 (21%)
		COG1033	<1157..>1274	CDD:331188	26/116 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3249
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960