DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disp and disp2

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_002940542.3	Gene:	disp2 / 100497287	XenbaseID:	XB-GENE-994606	Length:	1457	Species:	Xenopus tropicalis

Alignment Length:	1278	Identity:	351/1278 - (27%)
Similarity:	573/1278 - (44%)	Gaps:	289/1278 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETD 76
            |..::...|..|:....:..:.|.:..|::.::||||:|.:|||.|.|:||.:|..|.|:...|
Frog   173 YSQLITEWPLPVLAICLLLIIMCTLSGLLVGQMPDFSEPLMGFEPRDTEIGRKLITWGNMQTNT- 236

  Fly    77 HHGALFSNPSDLWERRRVEQGYVET-KLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQKM 140
                                ||.:| .::|:                   ..:||.:..|:.|
Frog   237 --------------------GYKKTLSVYPH-------------------SEKSSLDDTDLNQ-- 260

  Fly   141 MQFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEE 205
                                   |:..:|:               |||.:.    .|...|::|
Frog   261 -----------------------GNEKLFQ---------------TRRDQT----RNRRMVEQE- 282

  Fly   206 HQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRIGPNATDSLF 270
                                   ||         :||||| ..|.|.||..|..   .....||:
Frog   283 -----------------------DG---------VEGFFC-GPPEKSYSQLVFM---SKTAGSLW 311

  Fly   271 DLNGLLAMCQLQ-DQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSL 334
            :|..:.:||::: ::|...||:..||| ...|.|||..|||.||.|:|.|:|||.::|..|::..
Frog   312 NLQAIQSMCRMENEKIRSHPSFTEFCE-RSHTKECCPSWSLGNYIAVLYNRSSCMEITQSDISHT 375

  Fly   335 HTLLLGCYEYFHDLKMDNHC-------NEIPHC-RAPEECKRLNIVFNVLNFLTDFSFI--KSND 389
            .|||..|...:|...:...|       .:..|| :.||:|.|.:.|:.:|:||.|..|:  ::.|
Frog   376 LTLLRSCAPDYHRGALTPSCIGPRSERAKHSHCAKVPEKCIRSSAVYQLLHFLLDRDFLSPQTTD 440

  Fly   390 SNV-YLKYAMIFIPVAQSNRLLPLF-HEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVS 452
            ..| .|||:::|:|..:.:.::.:: ...|..:|.:....:..|||||:.:||...|:.|.....
Frog   441 YQVPSLKYSLLFLPAKKGSSMMNIYLDNLESWDLFDNYTAITGMDLGLKQQLFQHYLVLDTVYPV 505

  Fly   453 LGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADD 517
            |....:..|::.|..|.|||.|..:::..||.:::|.|.::....|||::||:|.:::..|.|:.
Frog   506 LAIIAIFLSIFFYLRSVFITFMIMISVIGSLLISFFLYKLIFRLTFFPFVNLIAGILLSSICANH 570

  Fly   518 VFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTA 582
            .|:|..:|:            |:....||...::...|          ||.|....|.|:..|..
Frog   571 AFVFFDLWN------------LSKIQHSAAGLMQWVSH----------TMHHFGYLMVVSCFTMG 613

  Fly   583 GAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFAT----------RMSCHH 637
            .||||:|.||||:::||.|:.|:.|:.|.:.||:||||::.:.||..|.          ..|.|
Frog   614 AAFYATYMSSITSVRCFAIYMGSSVLVNMIFMISWLPATIVVYERYIAVNCSYKSEEYWNSSTH- 677

  Fly   638 PMSIKLIHACKKSINRFCQ---------------MFEECITKSIMNYAYLWLLIFGALGASSAVI 687
                      |:.:..|||               :||:.:...::.:.|:|:..|.||.|..|.|
Frog   678 ----------KRLLLSFCQKFKGLQSTLSETSKLLFEKLLPCGVIKFRYIWICWFAALAAGGAYI 732

  Fly   688 VFWYPGLQLP--EKSHFQLFVSKHPFEVY-SSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDG 749
            ....|.|:||  |.|..|:|...||||.| :....||.|::. :..|...|.:..:||:..:|:.
Frog   733 ACMSPKLKLPSSEMSSLQVFRLSHPFERYDAEYCHQFMFDRS-EHGEGQHMPITLIWGIMPLDNS 796

  Fly   750 DYTNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPN-CFIENLIDYMK-R 812
            |:.||.:.|.|..|..|.:.:...|.|:::.|..|:.|.||....|. .|| ||:|:...:|: |
Frog   797 DHLNPKANGTLVTDATFTIRNAEDQNWLMELCHKVKNQSFYYSDQGK-KPNICFMEDFHRWMESR 860

  Fly   813 RCIDDMDSTRKDRSPCCD-AQFPFEPHIFEYCLPQSI-------SNMYDTTFFRPGVAGPKFAEA 869
            :|    ..|.::.:.||: ..||::..|..:|:...:       :.:||        .||:|
Frog   861 QC----SQTDQNLNLCCNHVTFPYKSDILLHCIKMMVREQGGDGTEVYD--------IGPRF--- 910

  Fly   870 PRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQL 934
                               ..:|:.|     |||:||::...||..|:..::||.::..|...::
Frog   911 -------------------DADGNLT-----ALVLEFQTVYHYSFNYSKTKKFYNTLNQWLMNEM 951

  Fly   935 KTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSI 999
            :.||..||.|||||.|..||:|.||:.:..|....::|.|..|||..|.|:.:|::||..:..|:
Frog   952 RNAPSGLQNGWFTSKLSLYNLQHTLNTEIMVVTSFSIAISFVVLLLTTWNVFLSLFAVAAIGGSV 1016

  Fly  1000 FNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVM 1064
            ..|..:|:||.||||::||:.:|.|:||:|||:.:|.|.|.:.|.::||:...|.|.::...|.|
Frog  1017 MVTTGLLVLLEWQLNVIESLLISAAVGLSVDFTTNYCISYHLCPHQDRLSRVAFSLKQMSCATAM 1081

  Fly  1065 AATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSK 1129
            .|:|...||.||:.:.:|.|.::|:|::::..:|..:|:||..||....||:....::.||.
Frog  1082 GASTMFSAGIIMLPATVLAYRKLGIFIIMIKCISCGFASFFFQSLCCFFGPEMNCGQIIWPC--- 1143

  Fly  1130 RSSGSSKFYERKPSQVIASEQLLTPTSSAI-----------------VELAN--SETHELESLNS 1175
                :|.|.|             .|..|.:                 |:.:|  :|.:||:.|..
Frog  1144 ----ASAFKE-------------YPNDSRLNGTFVCGGTEKHNRIRKVQESNTDNEQYELQPLAR 1191

  Fly  1176 NSLIKTISGIESAHALSSLPRDFEHSFQTMHECKYQTYPSTSN 1218
            | |..:.........||..|.......| :.|.||....|..|
Frog  1192 N-LSDSFDNSTCTSKLSKRPSMVSEDIQ-ISEYKYPKLGSQQN 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	214/704 (30%)
		MMPL	457..627	CDD:304422	53/169 (31%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	53/144 (37%)
disp2	XP_002940542.3	COG1033	<505..660	CDD:223964	56/176 (32%)
disp2	XP_002940542.3	COG1033	<970..>1123	CDD:223964	57/152 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1235
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1156918at2759
OrthoFinder	1	1.000	-	-		FOG0002571
OrthoInspector	1	1.000	-	-		otm48878
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2285
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060