Protein Alignment disp and disp1

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_002940743.2
• Gene: disp1 / 100496804
• XenbaseID: XB-GENE-1018540
• Length: 1201
• Species: Xenopus tropicalis
• Alignment Length: 1211
• Identity: 375/1211 - (30%)
• Similarity: 594/1211 - (49%)
• Gaps: 235/1211 - (19%)

  Fly    12 YYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETD 76
            |..::|..|.:|:....|..|.|.:|.:::..|||||||.||||.|||.||:||..|.|:::.|.
 Frog   177 YAALIADWPVVVLGMCTVIIVVCALVGILVPDLPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTG 241

  Fly    77 HHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQKMM 141
            :...|.:.|.                                     |..::.:..|.|
 Frog   242 YKATLANYPF-------------------------------------KYADEQAKNHQD------ 263

  Fly   142 QFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEH 206
                              |.|                                        .|:|
 Frog   264 ------------------DRW----------------------------------------SEDH 270

  Fly   207 QQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRI-GPNATDSLF 270
            .:| :.:::.|...|                   :.||| :.|...||..|...: |.|    |:
 Frog   271 YER-EKRQADWNFHK-------------------DSFFC-AVPNDHYSRVVFTSVEGEN----LW 310

  Fly   271 DLNGLLAMCQLQD-QITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSL 334
            :|..:.:||.:.: :|...|.:...|: ......||..|:|.||.|:|.|:|||..:...||:..
 Frog   311 NLRSIKSMCSIDNSRIRSHPQFADLCQ-RTSADSCCPSWTLGNYIAILNNRSSCQKIVERDVSHT 374

  Fly   335 HTLLLGCYEYFHDLKMDNHC--------NEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSN 391
            ..|:..|.:|:|:..:...|        :::.....|.:|.:.|.|:.:|::|.|..|:....:.
 Frog   375 LKLIRTCAKYYHNGTLGPDCWDMAAKRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFLSPKTAE 439

  Fly   392 VY---LKYAMIFIPVAQSNRLLPLF-HEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVS 452
            ..   ||::|:|.|..:...::.:: ..:|:....:.:..|..::.|:::.||.:.||.|....:
 Frog   440 YVMPALKHSMLFSPTEKGESMMRIYLDNFENWNCSDGVTTVTGIEFGIKHSLFQDYLLMDTVYPA 504

  Fly   453 LGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADD 517
            :....|:..:.:||.|.|||||:..||..||.::||.|.:|..|||||:|||.|:::::||||||
 Frog   505 IAIVIVLLVMCVYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADD 569

  Fly   518 VFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTA 582
            .|:...:|:.                     |..:..|.|:.|.: :.|::|||.||||||.|||
 Frog   570 AFVLCDVWNY---------------------TKFDKPHAETSETV-STTLQHAALSMFVTSFTTA 612

  Fly   583 GAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHAC 647
            .||||:|.|:||||:|||::|||.::.||:||:|||||.|.:.||......||......:..:
 Frog   613 AAFYANYISNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFSCFKKPQQRQYN-- 675

  Fly   648 KKS------------INRFCQ----MFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQL 696
            |||            :..|.:    .||:.:...::.:.|:|:..|.|:....|.||...|.::|
 Frog   676 KKSCWNVLWEKAQSLLFTFSEASRIFFEKVLPCIVIKFRYIWVFWFLAITVGGAYIVCVNPKMKL 740

  Fly   697 P--EKSHFQLFVSKHPFEVY-SSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSYG 758
            |  |.|.||:|.:.||||.| |..|:.|.||: :...|...|.:..||||...|:||..||.|.|
 Frog   741 PSLELSEFQVFRASHPFERYDSEYKKIFMFER-VHHGEELHMPITIVWGVSPEDNGDPLNPKSKG 804

  Fly   759 HLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRK 823
            .|..|::||::|..:|.|||.|||.::.|.|:.:|......:||||....:|     ::.|....
 Frog   805 KLKLDSSFNIASPASQQWILRFCQKLKNQTFFYQTDEQDFTSCFIETFKQWM-----ENQDCDEP 864

  Fly   824 DRSPCC-DAQFPFEPHIFEYCLPQSISNMYDTTFFR-----PGVAGPKFAEAPRLETEDYLGMSG 882
            ...||| .:.||::..:||.|:.::|..:..:|.:.     ||         ||.:..|
 Frog   865 SLYPCCSQSSFPYKQEVFELCIKRAIMELERSTGYHLDSKTPG---------PRFDIND------ 914

  Fly   883 NESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFT 947
                           .::|:|:||.|...::..|..:.|||:.|..|...:|::||..|..|||.
 Frog   915 ---------------TIRAVVLEFPSTYLFTLAYEKMHQFYKEVNAWIANELQSAPEGLSNGWFV 964

  Fly   948 SDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQ 1012
            |:|:||::||:||..|.:|:.|::|.:.:|:|..|.||::|:||:::::.:||.||..|:||||:
 Frog   965 SNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIILSVYAIVSIAGTIFVTVGSLVLLGWE 1029

  Fly  1013 LNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMM 1077
            ||:|||:.:|.|:||:|||::|||:.||::|..:|.....|.|||:.....|||.||.:||.:||
 Frog  1030 LNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVVFSLSRMGSAIAMAALTTFVAGAMMM 1094

  Fly  1078 ASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQH--GFLELKWPLWSKRSSG--SSKFY 1138
            .|.:|.|.|:|.|::::|.|||.:||||...:.|..|||.  |.:.|...|..|..|.  ||:..
 Frog  1095 PSTVLAYTQLGTFMMLIMCVSWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQFKAFSQALSSRTA 1159

  Fly  1139 ERKPSQVIASE--QLLTPTSSAIVELANSETHELESLNSNS 1177
            ||..:::..|.  ||.|..:...||   .|.:|||.|.:::
 Frog  1160 ERGQNKLNHSNKYQLDTRGTKTDVE---HEHYELEPLATHN 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	257/691 (37%)
		MMPL	457..627	CDD:304422	77/169 (46%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	66/144 (46%)
disp1	XP_002940743.2	Patched	431..1089	CDD:355433	250/717 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14133
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1156918at2759
OrthoFinder	1	1.000	-	-		FOG0002571
OrthoInspector	1	1.000	-	-		otm48878
Panther	1	1.100	-	-	O	PTHR45951
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3249
SonicParanoid	1	1.000	-	-		X2285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.050