Protein Alignment disp and ptch2

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_002937129.2
• Gene: ptch2 / 100492958
• XenbaseID: XB-GENE-1033868
• Length: 1423
• Species: Xenopus tropicalis
• Alignment Length: 961
• Identity: 179/961 - (18%)
• Similarity: 319/961 - (33%)
• Gaps: 358/961 - (37%)

  Fly   451 VSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGA 515
            |.|.|..::|          :::.|.:.:|..||::  |.|...  :..|::.|       |||.
 Frog   450 VGLAGVLLVA----------LSVASGLGLCSLLGIS--FNAATT--QVLPFLAL-------GIGV 493

  Fly   516 DDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLT 580
            ||:||        |...|       |::..:.|..|.:..          .:|....|:.:||:.
 Frog   494 DDMFL--------LAHAF-------TETSLSTPFKERTGE----------CLRRTGTSVALTSIN 533

  Fly   581 TAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSI---------MERLFATRMSC- 635
            ...||:.:....|.|::.|.:.|..|||.|:.:::...||.:|:         ::.|......|
 Frog   534 NMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCS 598

  Fly   636 -------------------HHPMS---------------IKLIHACKKSINRF------------ 654
                               :||.|               ::....|..|.:..
 Frog   599 SRVIQIQPQEFSDANDNHTYHPSSYGNPTITTSTQITTTVQAFTQCDPSGHHIVTILPPTSQIST 663

  Fly   655 -------------CQMF-------------------EECI------------------------- 662
                         .|:|                   .||:
 Frog   664 SPSVIVPTMDPLGSQVFSPSSSTRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVLLKAE 728

  Fly   663 TKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQL----PEKSHFQLFVS---KHPFEVYSSL--- 717
            ||.|:...::.||..|..|.:..     :.||.|    |.::....|:|   |: |..|:..
 Frog   729 TKGIVVALFMALLGLGLYGTTMV-----HDGLYLTDIVPRETKEYNFISAQFKY-FSFYNMFIVT 787

  Fly   718 KQQFWFEKPLQA----YENF---------------KMHMHFV--W--GVQAVDDGDYTNPNSYGH 759
            |..|.:.|..::    :|.|               ||.:|:.  |  |:|...|.|:    ..||
 Frog   788 KDGFDYPKAQESLYDLHEAFGSVKYVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDW----ELGH 848

  Fly   760 LHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKD 824
            :..|:..|.:......:.|......:::||               |......||.:|:.....:|
 Frog   849 ITEDSYRNGTEDSVLAFKLLIQTGNKKEPF---------------NFNQLTSRRLVDEKGLIPQD 898

  Fly   825 -----------RSP----CCDAQFPFEPHIFEYCLPQSISNMYDTT--FFRPGVAGP-KFAEAP- 870
                       ..|    ...|.|..:|       |:.|.:.||||  ..|...|.| :||:.|
 Frog   899 AFYIYLTVWVSNDPLGYAASQANFYPQP-------PEWIHDRYDTTGENLRIPAAEPIEFAQFPF 956

  Fly   871 ----RLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEF--ESNVAYSTIYANIRQFYE---SV 926
                ..:|.|::     |:.|          .|:::..||  :...:|.:.|..:  |:|   .:
 Frog   957 YLNGLRQTSDFI-----EAIE----------SVRSVCEEFVKQGVQSYPSGYPFL--FWEQYIGL 1004

  Fly   927 EHWFQMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYA 991
            .|||.:.:                            :.|..|..:..::.:|..:|..|::.|.|
 Frog  1005 RHWFLLAI----------------------------SIVLACTFLVCAILLLNPWTAGIIVFILA 1041

  Fly   992 VLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLS 1056
            ::||.|     ..::.|:|.:|:.:..:.:..::|:.|:|::|..:.: ::.:.:|...:...|.
 Frog  1042 MMTVEL-----FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGF-LTAIGDRNQRSVLALE 1100

  Fly  1057 RIIGPTVMAATTTGLAGGIMMASNILPYIQIGVF--LVVVMIVSWFYATFFLMSLLRVAGPQHGF 1119
            .:..|.:..|.:| |.|.:|:|.:...:|....|  |.::.|:........|..||.:.||
 Frog  1101 HMFAPVLDGAIST-LLGVLMLAGSEFDFILRYFFAVLTILTILGLLNGLVLLPVLLSLIGP---- 1160

  Fly  1120 LELKWPLWSKRSSGSSKFYERKPSQVIA---SEQLLTPTSSAIVELANSETHEL---------ES 1172
                                  |::|..   |.:|.|||...:....|.....:         :|
 Frog  1161 ----------------------PAEVTPADNSSRLPTPTPEPLPPPLNHHAFYMNHKGFSDPEDS 1203

  Fly  1173 LNSNSLIKTISGIE---------SAHALSSLPRDFEHSFQTMHECKYQTYP 1214
            ....|...|.||:|         ||:.:...|...     .:...|..|||
 Frog  1204 SEYYSETTTTSGLEEDDPQLYERSAYIIPPKPPHI-----ILEASKDPTYP 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	156/839 (19%)
ptch2	XP_002937129.2	2A060602	26..1172	CDD:273338	161/877 (18%)