Protein Alignment disp and ptch1

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_031746817.1
• Gene: ptch1 / 100492061
• XenbaseID: XB-GENE-488222
• Length: 1436
• Species: Xenopus tropicalis
• Alignment Length: 984
• Identity: 179/984 - (18%)
• Similarity: 320/984 - (32%)
• Gaps: 328/984 - (33%)

  Fly   393 YLKYAMIFIPVAQSNRLLP--------LFHEWEDVELINELVEVVAMDLGLENELFNELLLTDVW 449
            |::.....:|...|.::||        :...:.||.:|......:.|       |....|....|
 Frog   397 YVQVVHQSVPQNSSQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLM-------LAYACLTMLRW 454

  Fly   450 -------LVSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAV 507
                   .|.|.|..::|          :::.:.:.:|..:|::  |.|...  :..|::.|
 Frog   455 DCAKSQGAVGLAGVLLVA----------LSVAAGLGLCSLIGIS--FNAATT--QVLPFLAL--- 502

  Fly   508 VVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAA 572
                |:|.|||||        |...||.     |.....:|          .|:.....::...|
 Frog   503 ----GVGVDDVFL--------LAHAFSE-----TGQNKRIP----------FEDRTGECLKRTGA 540

  Fly   573 SMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSI-MERLFATRMSCH 636
            |:.:||::...||:.:....|.|::.|.:.|..|||.|:.:::...||.:|: :.|....|:.
 Frog   541 SVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREVRRLD-- 603

  Fly   637 HPMSIKLIHACKKS--INRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEK 699
                   |..|..|  ::|..|:..:..|.:..|..|                     ....|..
 Frog   604 -------IFCCFSSPCVSRVIQIEPQAYTDNNDNTRY---------------------SPPPPYS 640

  Fly   700 SHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAV----------------DD 748
            ||  .|..:....:.|:::.:..::...|.|.........: .||..                ..
 Frog   641 SH--SFAHETQITMQSTVQLRTEYDPRTQLYYTTAEPRSEI-SVQPAAPSPQDVSGQTPESTSST 702

  Fly   749 GDYTNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYM--- 810
            .|..:|.|...:|      ....|...|.|.........||      :|.||..:..::.::
 Frog   703 RDLLSPFSESGVH------CIEPPCTKWTLSSFAEKHYAPF------LLKPNTKVAVILVFLALL 755

  Fly   811 ------KRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTT-------------- 855
                  ..|..|.:|.|  |..|....::.|....|:|.   |..:||..|
 Frog   756 SVSLYGTTRVRDGLDLT--DIVPRETREYDFIATQFKYF---SFYHMYVVTQKADYPRAQRLLYE 815

  Fly   856 -------------------------FFRPGVAG-----PKFAEAPRLETEDYLGMSGNESAEY-- 888
                                     :||..:.|     .:..||.::...||...|.:....|
 Frog   816 LHKSFAGVKYVLLEGNKQLPRMWLHYFRDWLQGLQDTFDREWEAGKITHNDYRNASDDAVLAYKL 880

  Fly   889 --STNGSFTPL----LVKALVIEFE----------------SN--VAYSTIYANIRQFYESVEHW 929
              .|..|..|:    |.|..:::.:                ||  |||:...||||   .....|
 Frog   881 LIQTGNSDKPINLNQLTKQRLVDTDGIIQPNAFYIYLTAWVSNDPVAYAASQANIR---PHPPEW 942

  Fly   930 FQ---------MQLKTAPP--------ELQGGWFTSD---------------------------- 949
            ..         ..::.|.|        .|.|...|||
 Frog   943 LHDKADDRPETRTIRAAEPIEYVQFPFYLNGLRETSDFVEAIEKVRAICNNYTSLGVSSYPNGYP 1007

  Fly   950 LKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVN-----ILISIYAVLTVSLSIFNTVAVLILL 1009
            ..|:.....|.|...::|.:.:|.:..|...|.:|     |::.:.|::||.|     ..::.|:
 Frog  1008 FLFWEQYIGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-----FGMMGLI 1067

  Fly  1010 GWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGG 1074
            |.:|:.:..:.:..::|:.|:|::|..:.: ::.:.::.......|..:..|.:..|.:| |.|.
 Frog  1068 GIKLSAVPVVILIASVGIGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVST-LLGV 1130

  Fly  1075 IMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRV-------------------AGPQHGFL 1120
            :|:|.:...:           ||.:|:|...:::||.|                   ..|.:|..
 Frog  1131 LMLAGSEFDF-----------IVRYFFAVLAILTLLGVLNGLVLLPVLLSYFGPYPEVSPTNGRD 1184

  Fly  1121 ELKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVELANSETHELESLNSNSLIKTISGI 1185
            .|::|             :..|..::.......||.:.    ::|...|..|..      |:|||
 Frog  1185 RLEFP-------------QEPPPNIVRFPVHPRPTQNG----SDSSDSEYSSQT------TVSGI 1226

  Fly  1186 -ESAHALSS 1193
             |..|...|
 Frog  1227 SEELHQYDS 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	161/901 (18%)
ptch1	XP_031746817.1	2A060602	37..1198	CDD:273338	167/935 (18%)