DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tio and TSHZ3

DIOPT Version :9

Sequence 1:	NP_001260679.1	Gene:	tio / 44272	FlyBaseID:	FBgn0028979	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_065907.2	Gene:	TSHZ3 / 57616	HGNCID:	30700	Length:	1081	Species:	Homo sapiens

Alignment Length:	1091	Identity:	210/1091 - (19%)
Similarity:	339/1091 - (31%)	Gaps:	399/1091 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PQSAAMAAYLAAAQQNHLLLTNPLAAAASLVQHA--TQQAVVEGEVES----PALDFSRKRPKSH 156
            |:....|...|||..:..|      .||:||...  .::...:||..:    |..:.:|..|...
Human     2 PRRKQQAPRRAAAYVSEEL------KAAALVDEGLDPEEHTADGEPSAKYMCPEKELARACPSYQ 60

  Fly   157 GDDDQE-EDQEQDQEQEQEQEPDHDVQCDNGPLDLSVSTGKRQESVSPPARKIPRS-----ISAD 215
            .....| ...|.|.|....:..|.....::|    |:...:..:.|:.|......|     :.|.
Human    61 NSPAAEFSCHEMDSESHISETSDRMADFESG----SIKNEEETKEVTVPLEDTTVSDSLEQMKAV 121

  Fly   216 YKSPLPPGSWMPPINPYL--------------AAVAAKTGGLGYSKLAPSEASKALEKMTEMSRL 266
            |.:.|....| ..:|..|              ::.::.:.|.|......|..:|.|::::: ||:
Human   122 YNNFLSNSYW-SNLNLNLHQPSSEKNNGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQ-SRM 184

  Fly   267 ETSPTAARSLGAT-------SSVGAGVPAGASSNSGGRHSAWQSHWLNKGADTAKDVFKCVWCKQ 324
            ...|    ||.:|       |.:...:..|||.                        |:|..|..
Human   185 LPEP----SLFSTVQLYRQSSKLYGSIFTGASK------------------------FRCKDCSA 221

  Fly   325 SFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPTRLATSASNSACSSSSSSTSSSSNSS 389
            ::.||..||.||.||.|                                   ....:..:.:|:.
Human   222 AYDTLVELTVHMNETGH-----------------------------------YRDDNHETDNNNP 251

  Fly   390 KSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNI 454
            |       :.:.|..|.|:..:      |.|..:::||||:||.||.||.:::.||.:|:||..:
Human   252 K-------RWSKPRKRSLLEME------GKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKV 303

  Fly   455 ISQEQI--ISWKSGDERERPTNTGVPSTSTAA------PSSPSCTA------------------- 492
            ..:|.:  ::.|.           :|:|...|      ||||..|.
Human   304 PLKEPVTPVAAKI-----------IPATRKKASLELELPSSPDSTGGTPKATISDTNDALQKNSN 357

  Fly   493 PSV----------------------SAVLTCKVCDQAFGSLKELSTHMAQKSHY----------- 524
            |.:                      |.:|.|..|..:..:|:||:.||....|:
Human   358 PYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKG 422

  Fly   525 ---KESPAPSA----------SPPAAGTGNPKRGRQNRNEKRKKSLPVRKLLELERSGSNSSLDS 576
               .|:|....          |.|.|.|..........:...|.::.|:|.::.|::.::.....
Human   423 KPIVETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAVTDEKPKQ 487

  Fly   577 ALKPLRDFAAATKITCEKCGSKIETALFVEHIRKCLGESIPIPPRRSNAGVDRLPSPSLGLGAEK 641
            ..||..:.        |||....:.....|:                    |...||..||
Human   488 KDKPGEEE--------EKCDISSKYHYLTEN--------------------DLEESPKGGL---- 520

  Fly   642 PPSVLNALEQLIEKSFESRTSRTMTHGGYS--EAGTPLGASILKRLGIEDSSDYTKPLMDAQAMH 704
              .:|.:||..:..:.....:.|.:.|||.  .|...|...:...||....|...||:.
Human   521 --DILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMF------ 577

  Fly   705 LLRSSFASRDRSASESSSASRVESSYTPDRQQATP------H--------------------KSP 743
                       ..||..|.::.::..:|...|.:|      |                    |.|
Human   578 -----------GNSEIVSPTKNQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEP 631

  Fly   744 DTPAPPPPPPPTIKAEPLEAEPLVGCDREGCSPRQQIQVKKEFSMEACRESP-RSVSKSPAPQTE 807
            |....||.     :|.|           ..||.    :|.:...|||..:.. ||...||:|..:
Human   632 DGKLSPPK-----RATP-----------SPCSS----EVGEPIKMEASSDGGFRSQENSPSPPRD 676

  Fly   808 --------RSPPDNGSLLALNSMFDQLSGVENSGNNNSGHCFNNNNSCSSVS---AQKPKAHPLA 861
                    ..|.:||..| :..:...|||                 |.:.::   .::|..:||:
Human   677 GCKDGSPLAEPVENGKEL-VKPLASSLSG-----------------STAIITDHPPEQPFVNPLS 723

  Fly   862 ALQKLCE------------TTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWACNEAVLSA 914
            |||.:..            ..||.|...:.::|.....|.||.|
Human   724 ALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPP--------------------- 767

  Fly   915 SNGGSAGDSSIIKCSYCDTPFASKGAYRHHLSK--VHFVKDAGEDSPRLKSPAVQSPRSMPLASP 977
                               |..||.|  .||.:  .|...|...|..:.||....|..|: |.||
Human   768 -------------------PLQSKKA--DHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSV-LLSP 810

  Fly   978 RRSASRSPATGSQQPPPSPT---ISPYDESP--QSKFLKYTELAKQLSSKN 1023
               .|.:|||.|.....:.|   :|....||  ::.....:::.|.|:..:
Human   811 ---TSTAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESH 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tio	NP_001260679.1	zf-C2H2_2	<317..>344	CDD:289522	12/26 (46%)
		C2H2 Zn finger	319..341	CDD:275371	10/21 (48%)
		C2H2 Zn finger	428..450	CDD:275371	11/21 (52%)
		zf-C2H2_4	927..949	CDD:290605	6/23 (26%)
TSHZ3	NP_065907.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..161		0/19 (0%)
		C2H2 Zn finger	216..238	CDD:275371	10/21 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..257		3/60 (5%)
		C2H2 Zn finger	277..299	CDD:275371	11/21 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..364		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..502		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..604		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..687		18/80 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..897		0/4 (0%)
		homeodomain	892..960	CDD:238039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I5022
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.070