DRSC/TRiP Functional Genomics Resources

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Protein Alignment tio and TSHZ3

DIOPT Version :10

Sequence 1:NP_524733.2 Gene:tio / 44272 FlyBaseID:FBgn0028979 Length:1024 Species:Drosophila melanogaster
Sequence 2:NP_065907.2 Gene:TSHZ3 / 57616 HGNCID:30700 Length:1081 Species:Homo sapiens


Alignment Length:1091 Identity:210/1091 - (19%)
Similarity:339/1091 - (31%) Gaps:399/1091 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 PQSAAMAAYLAAAQQNHLLLTNPLAAAASLVQHA--TQQAVVEGEVES----PALDFSRKRPKSH 156
            |:....|...|||..:..|      .||:||...  .::...:||..:    |..:.:|..|...
Human     2 PRRKQQAPRRAAAYVSEEL------KAAALVDEGLDPEEHTADGEPSAKYMCPEKELARACPSYQ 60

  Fly   157 GDDDQE-EDQEQDQEQEQEQEPDHDVQCDNGPLDLSVSTGKRQESVSPPARKIPRS-----ISAD 215
            .....| ...|.|.|....:..|.....::|    |:...:..:.|:.|......|     :.|.
Human    61 NSPAAEFSCHEMDSESHISETSDRMADFESG----SIKNEEETKEVTVPLEDTTVSDSLEQMKAV 121

  Fly   216 YKSPLPPGSWMPPINPYL--------------AAVAAKTGGLGYSKLAPSEASKALEKMTEMSRL 266
            |.:.|....| ..:|..|              ::.::.:.|.|......|..:|.|::::: ||:
Human   122 YNNFLSNSYW-SNLNLNLHQPSSEKNNGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQ-SRM 184

  Fly   267 ETSPTAARSLGAT-------SSVGAGVPAGASSNSGGRHSAWQSHWLNKGADTAKDVFKCVWCKQ 324
            ...|    ||.:|       |.:...:..|||.                        |:|..|..
Human   185 LPEP----SLFSTVQLYRQSSKLYGSIFTGASK------------------------FRCKDCSA 221

  Fly   325 SFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPTRLATSASNSACSSSSSSTSSSSNSS 389
            ::.||..||.||.||.|                                   ....:..:.:|:.
Human   222 AYDTLVELTVHMNETGH-----------------------------------YRDDNHETDNNNP 251

  Fly   390 KSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNI 454
            |       :.:.|..|.|:..:      |.|..:::||||:||.||.||.:::.||.:|:||..:
Human   252 K-------RWSKPRKRSLLEME------GKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKV 303

  Fly   455 ISQEQI--ISWKSGDERERPTNTGVPSTSTAA------PSSPSCTA------------------- 492
            ..:|.:  ::.|.           :|:|...|      ||||..|.                   
Human   304 PLKEPVTPVAAKI-----------IPATRKKASLELELPSSPDSTGGTPKATISDTNDALQKNSN 357

  Fly   493 PSV----------------------SAVLTCKVCDQAFGSLKELSTHMAQKSHY----------- 524
            |.:                      |.:|.|..|..:..:|:||:.||....|:           
Human   358 PYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKG 422

  Fly   525 ---KESPAPSA----------SPPAAGTGNPKRGRQNRNEKRKKSLPVRKLLELERSGSNSSLDS 576
               .|:|....          |.|.|.|..........:...|.::.|:|.::.|::.::.....
Human   423 KPIVETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAVTDEKPKQ 487

  Fly   577 ALKPLRDFAAATKITCEKCGSKIETALFVEHIRKCLGESIPIPPRRSNAGVDRLPSPSLGLGAEK 641
            ..||..:.        |||....:.....|:                    |...||..||    
Human   488 KDKPGEEE--------EKCDISSKYHYLTEN--------------------DLEESPKGGL---- 520

  Fly   642 PPSVLNALEQLIEKSFESRTSRTMTHGGYS--EAGTPLGASILKRLGIEDSSDYTKPLMDAQAMH 704
              .:|.:||..:..:.....:.|.:.|||.  .|...|...:...||....|...||:.      
Human   521 --DILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMF------ 577

  Fly   705 LLRSSFASRDRSASESSSASRVESSYTPDRQQATP------H--------------------KSP 743
                       ..||..|.::.::..:|...|.:|      |                    |.|
Human   578 -----------GNSEIVSPTKNQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEP 631

  Fly   744 DTPAPPPPPPPTIKAEPLEAEPLVGCDREGCSPRQQIQVKKEFSMEACRESP-RSVSKSPAPQTE 807
            |....||.     :|.|           ..||.    :|.:...|||..:.. ||...||:|..:
Human   632 DGKLSPPK-----RATP-----------SPCSS----EVGEPIKMEASSDGGFRSQENSPSPPRD 676

  Fly   808 --------RSPPDNGSLLALNSMFDQLSGVENSGNNNSGHCFNNNNSCSSVS---AQKPKAHPLA 861
                    ..|.:||..| :..:...|||                 |.:.::   .::|..:||:
Human   677 GCKDGSPLAEPVENGKEL-VKPLASSLSG-----------------STAIITDHPPEQPFVNPLS 723

  Fly   862 ALQKLCE------------TTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWACNEAVLSA 914
            |||.:..            ..||.|...:.::|.....|.||.|                     
Human   724 ALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPP--------------------- 767

  Fly   915 SNGGSAGDSSIIKCSYCDTPFASKGAYRHHLSK--VHFVKDAGEDSPRLKSPAVQSPRSMPLASP 977
                               |..||.|  .||.:  .|...|...|..:.||....|..|: |.||
Human   768 -------------------PLQSKKA--DHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSV-LLSP 810

  Fly   978 RRSASRSPATGSQQPPPSPT---ISPYDESP--QSKFLKYTELAKQLSSKN 1023
               .|.:|||.|.....:.|   :|....||  ::.....:::.|.|:..:
Human   811 ---TSTAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESH 858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tioNP_524733.2 zf-C2H2 317..337 CDD:395048 8/19 (42%)
C2H2 Zn finger 319..341 CDD:275371 10/21 (48%)
C2H2 Zn finger 428..450 CDD:275371 11/21 (52%)
zf-C2H2_4 927..949 CDD:464025 6/23 (26%)
TSHZ3NP_065907.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 141..161 0/19 (0%)
C2H2 Zn finger 216..238 CDD:275371 10/21 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..257 3/60 (5%)
C2H2 Zn finger 277..299 CDD:275371 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..364 6/38 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..502 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..604 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 626..687 18/80 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 855..897 0/4 (0%)
homeodomain 892..960 CDD:238039
Blue background indicates that the domain is not in the aligned region.

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