Protein Alignment tio and tshz3a

DIOPT Version :9

• Sequence 1: NP_001260679.1
• Gene: tio / 44272
• FlyBaseID: FBgn0028979
• Length: 1024
• Species: Drosophila melanogaster
• Sequence 2: XP_686844.3
• Gene: tshz3a / 558522
• ZFINID: ZDB-GENE-100322-1
• Length: 1021
• Species: Danio rerio
• Alignment Length: 1003
• Identity: 208/1003 - (20%)
• Similarity: 354/1003 - (35%)
• Gaps: 298/1003 - (29%)

  Fly   124 AASLVQHATQQAVVEGEVESPALDFSRKRPKSHGDDDQEEDQE---QDQEQEQEQEPDHDVQCDN 185
            ||:......::.||:.|........:::.|:  |::|..||.:   .:|:....:...|||..::
Zfish    12 AAAYDSENGKETVVQTEGTESVCPVTKENPQ--GENDLGEDFKNPMDEQDCSASELSGHDVDSES 74

  Fly   186 -------GPLDLSVSTGKRQESVSPPARKIPRS----------ISADYKSPL--PPGSWMPPINP 231
                   ...|...:|.|.:|:.....:....:          :.|.|||.|  |..|::...:|
Zfish    75 HISESSEPTSDAESTTIKNEEATKDFIKDSSENSVCITDSLEQMKAIYKSFLNNPYWSFLSLNSP 139

  Fly   232 --YLAAVAAKTGGLGYSKLAP---------SEASKALEKMTEMSRLETSPTAARSL----GATSS 281
              |.....|.:.|...|..:|         |..:|.|:::::...:...|:...::    .:|..
Zfish   140 QSYADEQPASSSGSSSSNSSPGRTCYDWHQSAIAKTLQQVSQKPPIALEPSIFSTVQLYRQSTKL 204

  Fly   282 VGAGVPAGASSNSGGRHSAWQSHWLNKGADTAKDVFKCVWCKQSFSTLANLTAHMKETQHCGVQI 346
            .|: :..|||.                        |.|..|..::.||.:||.||.||.|
Zfish   205 YGS-IFTGASK------------------------FHCKSCSAAYDTLLDLTVHMNETDH----- 239

  Fly   347 PSPLPTGGVGTPSAPPPTRLATSASNSACSSSSSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQ 411
                                  ...::..|:|.|..|.|....:|.|.|
Zfish   240 ----------------------YRDDNLESASKSGKSWSKPRKRSLLEM---------------- 266

  Fly   412 DVWLGKGAEQTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNIISQE-------QIISWKSGDER 469
                 :|.|..:::|:||:||.||.||.:::.||.:|:||..:..:|       :::|    ..|
Zfish   267 -----EGKEDAQKVLRCMYCGHSFESLQDLSVHMIKTKHYQKVPLREPRTAIAAKVVS----SFR 322

  Fly   470 ER-PTNTGVPST--STAAPSSPS-----------------------CTAPSV---SAVLTCKVCD 505
            :| |....|..:  :|....||:                       .|:..|   |..|.|..|.
Zfish   323 KRVPVELDVAKSLHTTEQTRSPNEGHTRDILQMYSEQNIKDDLDQKTTSRGVHFKSQNLKCLECG 387

  Fly   506 QAFGSLKELSTHMAQKSHYKESPAPSASPPAAGTGNPKRGRQNRNEKR------KKSLPVRKLLE 564
            .:..||::||.||....|:.:  ...:......|.:||    :::||.      ...|...::||
Zfish   388 ISHDSLQQLSAHMMLTGHFLK--VTQSLQKTDKTPHPK----SKSEKSLSETTCSSPLAATRILE 446

  Fly   565 LERSGSNSSLDSALKPLRDFAAAT-KITCEKCGSKIETALFVEHIRKCLGESIPIPPRRSNAGVD 628
               |.|.||:.:.     |....| :||.:|.....|:| .|..:|:.||.|         |..|
Zfish   447 ---SSSYSSIATG-----DHKNKTQEITSQKSSESKESA-NVNDVRQKLGPS---------AKTD 493

  Fly   629 RLPSPSLGLGAEKPPSVLNALEQLIEKSFESRTSRTMTHGGYSEAGTPLGASILKRLGIEDSSDY 693
            .|....|....:....:|.:||..:..:.........:.|||..    :.|:...|       ::
Zfish   494 YLTEDDLKESPKMDFDILKSLENTVTSAINKAQKGAPSWGGYQS----IHAAYQLR-------NH 547

  Fly   694 TKPLMDAQAMHLLRSSFASRDRSASESSSASRVESSYTPDRQQATPHKSPDTPAPPPPPPPTIKA 758
            .||     |:|  ...:.|   |..:|||:..|:|.   |:....|   |.|  .|.....|::.
Zfish   548 LKP-----ALH--NPGYIS---SLKQSSSSQEVQSL---DKSNLIP---PST--QPSSSSTTVQV 594

  Fly   759 EPLE------AEPLVGCDR-------EGCSPRQQIQVKKEFSMEACRESPRSVSKSPAPQTERSP 810
            ..::      .|.....||       :| ||..|:...|..|:         :.|||:|::
Zfish   595 SEVDELEMNVTEKDAEVDRKLKDLNGQG-SPHPQLLNLKGKSL---------MLKSPSPES---- 645

  Fly   811 PDNGSLLALNSMFDQLSGVENSGNNNSGHCFNNN--NSCSSVSAQ----KPKAHPLAALQKLCE- 868
                ::.:::.:.:..:..:.:..:.......:|  :..|.:|||    :|...||:|||.:..
Zfish   646 ----TVTSMSKITEGKTEEKETRKHKQDPTSTSNLYDDSSLLSAQPEPKQPSVSPLSALQSVMNL 706

  Fly   869 -----------TTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWACNEA------------ 910
                       ..||.|..||.::|.....|.|. ||.:...|......|:|.
Zfish   707 HLGKAAKPVRPVQDPMSMLLRMSNSMAERAALAG-PSGHSTKLSQLHSNCHEICRDQPIDLSKGK 770

  Fly   911 ----VLSASNGGSAGDSSIIKCSYCD-------TPFASKGAYRHHLSKVH--FVKDAGEDSPRLK 962
                :.:||..|.|..|||...|..:       ||          :|.:|  .:.|..:....|.
Zfish   771 NEQYLTTASVPGKALSSSISGASVSESNSPKIFTP----------VSPLHENALSDISDMLRNLS 825

  Fly   963 SPAVQSPRSMPLASPRRSASRSPATGSQ 990
            ...|..|.:: |..|.:|......|..:
Zfish   826 DSRVSKPPTL-LCRPEQSEIEGSRTSEE 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tio	NP_001260679.1	zf-C2H2_2	<317..>344	CDD:289522	12/26 (46%)
		C2H2 Zn finger	319..341	CDD:275371	10/21 (48%)
		C2H2 Zn finger	428..450	CDD:275371	11/21 (52%)
		zf-C2H2_4	927..949	CDD:290605	4/28 (14%)
tshz3a	XP_686844.3	C2H2 Zn finger	217..239	CDD:275371	10/21 (48%)
		C2H2 Zn finger	278..300	CDD:275371	11/21 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580304
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4973
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411087at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6467
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.120