DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tio and tsh

DIOPT Version :9

Sequence 1:NP_001260679.1 Gene:tio / 44272 FlyBaseID:FBgn0028979 Length:1024 Species:Drosophila melanogaster
Sequence 2:NP_523615.2 Gene:tsh / 35430 FlyBaseID:FBgn0003866 Length:954 Species:Drosophila melanogaster


Alignment Length:1093 Identity:360/1093 - (32%)
Similarity:468/1093 - (42%) Gaps:333/1093 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MLHEAVMLEIYRQALSASEL------------TSPRCQSRDSNTSA-GAGAGMADVRCPSNESHC 53
            |||||:|||||||||:|..|            :|.||.|.|||:|. |.|||...|         
  Fly     1 MLHEALMLEIYRQALNAGALPTARPRSTESANSSERCPSHDSNSSEHGGGAGSGGV--------- 56

  Fly    54 SANDRLTPAATPTLTPTEATISPNSVGLPLTATLPPAAAVALLPPQSAAMAAYL----AAAQQNH 114
              ..||..||..|      .:.|......|.::.|  |....||.|..:|.|||    |||||..
  Fly    57 --GHRLDAAALST------GVMPGEGPTTLHSSFP--AVPQSLPSQPPSMEAYLHMVAAAAQQYG 111

  Fly   115 LLLTNPLAAAAS----------LVQHAT-------QQAVVEGEVESPALDFSRKRPKSHGDDDQE 162
            .    ||||||:          |...|.       |.:.......|.||||   |...:|   :.
  Fly   112 F----PLAAAAAAGAGPRLPLPLANEAAAPFKLPPQASPTASSNNSEALDF---RTNLYG---RA 166

  Fly   163 EDQEQDQEQEQEQEPDHDVQCDNGPLDLSVSTGKRQESVSPPARKIPRSISADYKSPLPPGS--- 224
            |..|....:.:|:|.|...   |.||||||.|.||.....|....|  .:...:||..||.:   
  Fly   167 ESAEPPASEGEEEEFDDGA---NNPLDLSVGTRKRGHESEPQLGHI--QVKKMFKSDSPPANSVA 226

  Fly   225 ------WMPPINPYLAAVAA----KTGGLGYSKLAPSEASK------ALEKMTEM---------- 263
                  .:|.:|||||||||    :.|..      |...||      .||||:::          
  Fly   227 SPSASQLLPGVNPYLAAVAAANIFRAGQF------PDWNSKNDLVVDPLEKMSDIVKGGASGMGT 285

  Fly   264 -----SRLETSPTAAR---------SLGATSSVGAGVPAGASSNSG---GRHSAWQSHWLNKGAD 311
                 |...|:|.||.         :....|..|.|...||:.:..   .||:.|||||.|||  
  Fly   286 KEKMHSSKATTPQAASQPPKSPVQPTPNQNSESGGGSGGGAAGSGAVTKARHNIWQSHWQNKG-- 348

  Fly   312 TAKDVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSPLPTGGVGT---------PSAPPPTRLA 367
            .|..||:||||||||.||..||.|||:::||||.:|   |.|.:.:         |:.|||.:..
  Fly   349 VASSVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVP---PFGNLPSNNPQPQHHHPTPPPPPQNH 410

  Fly   368 TSASNSACSSSSSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCMWCG 432
            ....:   ||.|:|..|.|.:.|:..........||||||||||:||||||.||..||||||.||
  Fly   411 NLRKH---SSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCG 472

  Fly   433 QSFRSLAEMTSHMQETQHYTNIISQEQIISWKSGDERERPTNTGVPSTSTAAPSSPSCTAPSVSA 497
            :|||||.|||.|||||||||||:||||.||.|||:..   .|:....:..:..|..|.|   :||
  Fly   473 ESFRSLGEMTKHMQETQHYTNILSQEQSISIKSGNAN---ANSDAKESHNSLSSEESRT---LSA 531

  Fly   498 VLTCKVCDQAFGSLKELSTHMAQKSHYKESPAPSASP---PAAGTGNPKRGRQNRNEKRKKSLPV 559
            ||||||||:||.||.:||.|||:.:||.|....||..   ||     ||        ||:|||||
  Fly   532 VLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQSAGARKRPA-----PK--------KREKSLPV 583

  Fly   560 RKLLELERSGSNSSLDSALKPLRDFAAATKITCEKC------------GSKIETALFVEHIRKCL 612
            |||||: :.||.::.:..             :.||.            |.|.:.|||.|.:|:.:
  Fly   584 RKLLEM-KGGSGTTQEDH-------------SNEKTSVQGKPGLGPGGGDKNDAALFAERMRQYI 634

  Fly   613 GESIPIPPRRSNAGVDRL----PSPSL----------GLGAEKPPSVLNALEQLIEKSFE----- 658
             ..:..|...:.....:|    .||.|          ..||.   |||:|:||:...||:     
  Fly   635 -TGVKAPEEIAKVAAAQLLAKNKSPELVEQKNGGSAKAAGAS---SVLSAIEQMFTTSFDTPPRH 695

  Fly   659 -----SRTSRTMTHGGYSEAGTPLGASILKRLGIEDSSDYTKPLMDAQAMHLLRSSFASRDRSAS 718
                 |..|.:.|     :..:|:.:||||||||:::.||.|||:|....:.....:.|.:||.|
  Fly   696 ASLPASSPSNSST-----KNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGS 755

  Fly   719 ESSSASRVE-SSYTPDRQQATPHKSPDTPAPPPPPPPTIKAEPLEAEPLVGCDREGCSPRQQIQV 782
            |.|:.:|.. .:.||::||.......::      ..|.||.|           ||..|...::::
  Fly   756 ECSAEARPRLDAPTPEKQQQGGGHDEES------SKPAIKQE-----------REAESKPVKMEI 803

  Fly   783 KKEF-----------SMEAC---------------RESPRSVSKSPAPQTERSPP---------- 811
            |.||           .|||.               |.||::.|.:.:|||...||          
  Fly   804 KSEFVDEPNEAEETSKMEAAVVNGSATNNNNNIVERSSPKTPSSAASPQTRLLPPRSPAESQRSV 868

  Fly   812 ----------------------DNGSLLALNSMFDQLSGVENSGNNNSGHCFNNNNSCSSVSAQK 854
                                  .:.||.||:||||.| |...:|.|:...               
  Fly   869 TPKSPASSHKSYDGSSEGTKKFPSDSLNALSSMFDSL-GSSGAGANSRAK--------------- 917

  Fly   855 PKAHPLAALQKLCETTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWAC 907
                                  |.:|::||.|.:...| :|.||.|.|....|
  Fly   918 ----------------------LAAAAAAGGSESPENL-TAGGNSLAALRQFC 947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tioNP_001260679.1 zf-C2H2_2 <317..>344 CDD:289522 18/26 (69%)
C2H2 Zn finger 319..341 CDD:275371 15/21 (71%)
C2H2 Zn finger 428..450 CDD:275371 17/21 (81%)
zf-C2H2_4 927..949 CDD:290605
tshNP_523615.2 zf-C2H2_2 <354..>382 CDD:289522 19/27 (70%)
C2H2 Zn finger 356..378 CDD:275371 15/21 (71%)
C2H2 Zn finger 468..490 CDD:275371 17/21 (81%)
C2H2 Zn finger 535..557 CDD:275371 14/21 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45448401
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2CNCF
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 101 1.000 Inparanoid score I4973
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D411087at33208
OrthoFinder 1 1.000 - - FOG0016630
OrthoInspector 1 1.000 - - mtm6467
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR12487
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4785
SonicParanoid 00.000 Not matched by this tool.
98.930

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