DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tio and Tshz3

DIOPT Version :9

Sequence 1:	NP_001260679.1	Gene:	tio / 44272	FlyBaseID:	FBgn0028979	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_038967676.1	Gene:	Tshz3 / 308523	RGDID:	1306322	Length:	1083	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	217/1080 - (20%)
Similarity:	336/1080 - (31%)	Gaps:	404/1080 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PLAAAASLVQHATQQAVVEGEVE------------------------------SPALDFSRKRPK 154
            |..|||.:.......|:||.::|                              |||.:||.....
  Rat     9 PRRAAAYVSDELKAAALVEDDIEPEEQVADGEPSAKYMCPEKELSKACPSYQNSPAAEFSSHEMD 73

  Fly   155 SHGDDDQEEDQEQDQEQE--QEQEPDHDVQCDNGPL-DLSVSTGKRQESVSPPARKIPRSISADY 216
            |.....:..|:..|.|..  :.:|...:||.   || |.:||....|             :.|.|
  Rat    74 SESHISETSDRMADFESSSIKNEEETKEVQV---PLEDTTVSDSLEQ-------------MKAVY 122

  Fly   217 KSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLAPSEAS---------------KALEKMTEMSRL 266
            .:.|....| ..:|..|...:::..|.|.|..:.|.:|               |.|::::: :|:
  Rat   123 NNFLSNSYW-SNLNLNLHQPSSENNGGGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQ-NRM 185

  Fly   267 ETSPTAARSLGAT-------SSVGAGVPAGASSNSGGRHSAWQSHWLNKGADTAKDVFKCVWCKQ 324
            ...|    ||.:|       |.:...:..|||.                        |:|..|..
  Rat   186 LPEP----SLFSTVQLYRQSSKLYGSIFTGASK------------------------FRCKDCSA 222

  Fly   325 SFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPTRLATSASNSACSSSSSSTSSSSNSS 389
            ::.||..||.||.||.|                                   ....:..:.:|:.
  Rat   223 AYDTLVELTVHMNETGH-----------------------------------YRDDNHETDNNNP 252

  Fly   390 KSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNI 454
            |       :.:.|..|.|:..:      |.|..:::||||:||.||.||.:::.||.:|:||..:
  Rat   253 K-------RWSKPRKRSLLEME------GKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKV 304

  Fly   455 ISQEQIISWKSGDERERPTNTGVPSTSTAAPSSPSCTA-------------------PSV----- 495
            ..:|.:....:   :..|.....||.....||||..|.                   |.:
  Rat   305 PLKEPVTPVAA---KIIPAARKKPSLELELPSSPDSTGGTPKATLSDASDALQKNSNPYITPNNR 366

  Fly   496 -----------------SAVLTCKVCDQAFGSLKELSTHMAQKSHYKESPAPSASPPAAGTGNPK 543
                             |.:|.|..|..:..:|:||:.||....|:.:.
  Rat   367 YGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKV---------------- 415

  Fly   544 RGRQNRNEKRKKSLPVRKLLELERSGS-NSSLDSALK--PLRDFAAATKITCEKCGSKIETALFV 605
                 .|...||..|:   :|...:.: .:.||..::  ||   ||.|..:.....:.:...|.|
  Rat   416 -----TNSAMKKGKPI---METPVTPTITTLLDEKVQSVPL---AATTFTSPSNTPASVSPKLTV 469

  Fly   606 EHIRKCLGESIPI----PPRRSNAGV-----------------DRLPSPSLGLGAEKPPSVLNAL 649
            | |:|.:.:...:    |..:..|..                 |...||..||      .:|.:|
  Rat   470 E-IKKEVDKEKAVLDEKPKEKEKASEEEEKYDISSKYHYLTENDLEESPKGGL------DILKSL 527

  Fly   650 EQLIEKSFESRTSRTMTHGGYS--EAGTPLGASILKRLGIEDSSDYTKPLMDAQAMHLLRSSFAS 712
            |..:..:.....:.|.:.|||.  .|...|...:...||....|...||:.
  Rat   528 ENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMF-------------- 578

  Fly   713 RDRSASESSSASRVESSYTPDRQQATP------H--------------------KSPDTPAPPPP 751
               ..||..|.::.::..:|...|.:|      |                    |.||:...||.
  Rat   579 ---GNSEIVSPTKTQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDSKLSPPK 640

  Fly   752 PPPTIKAEPLEAEPLVGCDREGCSPRQQIQVKKEF-------SMEACRESPRSVSKSPAPQTERS 809
                 :|.|           ..||..|...:|.|.       |.|.....||.|.|..:|..|
  Rat   641 -----RATP-----------SPCSSEQSEPIKMEASSGSGFKSQENSPSPPRDVCKEASPSAE-- 687

  Fly   810 PPDNGSLLALNSMFDQLSGVENSGNNN--SGHCFNNNNSCSSVSAQKPKAHPLAALQKLCE---- 868
            |.:||     ..:...|||...||:..  :.|           ..::|..:||:|||.:..
  Rat   688 PVENG-----KELVKPLSGGSLSGSTAIITDH-----------PPEQPFVNPLSALQSVMNIHLG 736

  Fly   869 --------TTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWACNEAVLSASNGGSAGDSSI 925
                    ..||.|...:.::|.....|.||.|
  Rat   737 KAAKPSLPALDPMSMLFKMSNSLAEKAAVATPP-------------------------------- 769

  Fly   926 IKCSYCDTPFASKGAYRHHLSK--VHFVKDAGEDSPRLKSPAVQSPRSMPLASPRRSASRSPATG 988
                    |..:|.|  .||.:  .|...|...|..:.||....|..| .|.||   .|.||||.
  Rat   770 --------PLQAKKA--EHLDRYFYHVNNDQPIDLTKGKSDKGCSLGS-GLLSP---TSTSPATS 820

  Fly   989 SQQPPPSPT---ISPYDESP--QSKFLKYTELAKQLSSKN 1023
            |.....:.|   :|....||  ::.....:::.|.|:..:
  Rat   821 SSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESH 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tio	NP_001260679.1	zf-C2H2_2	<317..>344	CDD:289522	12/26 (46%)
		C2H2 Zn finger	319..341	CDD:275371	10/21 (48%)
		C2H2 Zn finger	428..450	CDD:275371	11/21 (52%)
		zf-C2H2_4	927..949	CDD:290605	5/23 (22%)
Tshz3	XP_038967676.1	C2H2 Zn finger	217..239	CDD:275371	10/21 (48%)
		C2H2 Zn finger	278..300	CDD:275371	11/21 (52%)
		homeodomain	894..962	CDD:238039
		zf-met	1043..1066	CDD:403930
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5308
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8976
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.080