DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tio and Tshz2

DIOPT Version :9

Sequence 1:	NP_001260679.1	Gene:	tio / 44272	FlyBaseID:	FBgn0028979	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_006499486.2	Gene:	Tshz2 / 228911	MGIID:	2153084	Length:	1050	Species:	Mus musculus

Alignment Length:	1025	Identity:	209/1025 - (20%)
Similarity:	343/1025 - (33%)	Gaps:	334/1025 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LPPQSAAMAAYLAAAQQNHLLLTNPLAAAASLVQHA-TQQAVVEGEVESPALDFSRKRPKSHGDD 159
            :||.|..:.||                  |.:.:|. .|:.|::.|.|....:...:...|....
Mouse    17 VPPVSRHLEAY------------------ARITKHGYAQEEVLKEEEEIKEEEEEEEDSGSVAQH 63

  Fly   160 DQEEDQEQDQEQEQEQEPDHDVQCDNGP-LDLSVSTGKRQESVSPPARKIP-------RSISADY 216
            ....|...|:|.|...|......|.|.| ..||....:.:..:|..:.::.       |.:| |.
Mouse    64 QSSNDTGTDEELETGPEQKGYFSCQNSPGSHLSNQDAENESLLSDASDQVSDVKSVCGRDVS-DK 127

  Fly   217 KSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLAPSEASKALEKMTEM--SRLETSPTAARSLGAT 279
            |:...|                        || |||....::|||.:  :.|..|..:...||..
Mouse   128 KANTHP------------------------KL-PSEPHNCMDKMTAVYANILSDSYWSGLGLGFK 167

  Fly   280 SSVGAGVPAGASSNSGGRHSAWQSHWLNKGAD-------------------------------TA 313
            .|..........::||.....|....|:|...                               |.
Mouse   168 LSNSERRNCDTRNSSGKNDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKLCGSVFTG 232

  Fly   314 KDVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPTRLATSASNSACSSS 378
            ...|:|..|..::.||..||.||.||.|
Mouse   233 ASRFRCRQCSAAYDTLVELTVHMNETGH------------------------------------- 260

  Fly   379 SSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCMWCGQSFRSLAEMTS 443
                ....|..|.:|.   ..:...|||.. .||:    ..|..:::||||:||.||.||.:::.
Mouse   261 ----YQDDNRKKDKLR---PTSYSKPRKRA-FQDM----DKEDAQKVLKCMFCGDSFDSLQDLSV 313

  Fly   444 HMQETQHYTNIISQEQI--ISWK---SGDER----ERP----TNTGVPSTSTAAPSSPSCTAPS- 494
            ||.:|:||..:..:|.:  ||.|   ...:|    .||    :.||..:.|.::..|.:...||
Mouse   314 HMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSLADSFSSQKSANLQLPSN 378

  Fly   495 ------------------VSAVLTCKVCDQAFGSLKELSTHMAQKSHYKESPAPSASPPAAGTGN 541
                              .|.:|.|..|..:..:|::|:|||....|:.:..: |||
Mouse   379 SRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTS-SAS-------- 434

  Fly   542 PKRGRQNRNEKRKKSLPVRKLLELERSGSNSSL---DSALKPLRDFAAATKITCEKCGSK----- 598
             |:|:|...:    .|.|.|:..|..:.::.||   .|:..|....|:.|::..|....|
Mouse   435 -KKGKQLVLD----PLAVEKMQSLSETPNSESLAPKPSSNSPSECTASTTELKKESKKEKGEGIE 494

  Fly   599 ----IETALFVEHIRKCLGESIPIPPRRSNAGVDRLPSPSLGLGAEKPPSVLNALEQLIEKSFES 659
                :::..:.:.::|.|..:|.....|.    :.|...|.|.|     .:|.:||..:..:...
Mouse   495 DEQGVKSEDYEDSLQKPLDPTIKYQYLRE----EDLEDGSKGGG-----DILKSLENTVTTAINK 550

  Fly   660 RTSRTMTHGGYSEAGTPLGASILKRLGIEDSSDYTKP--LMDAQAMHLLRSSFASRDRSASESSS 722
                       ::.|.|..::..........|:.|||  .|.:|.:. :|.:.|::.|..
Mouse   551 -----------AQNGAPSWSAYPSIHAAYQLSEGTKPPMAMGSQILQ-IRPNLANKLRPI----- 598

  Fly   723 ASRVESSYTPDRQQATPHKSPDTPAPPPPPPPT-------IKAEPLEAEPLV-GCDREGCSPRQQ 779
                               :|.....|..|.||       :|.|..:.:.:| .|.:|  ||.::
Mouse   599 -------------------APKWKGMPLGPVPTSLALYTQVKKETEDKDEVVKQCGKE--SPHEE 642

  Fly   780 IQ----------VKKEFSMEACRESPRSVSKSPAPQTERSPPDNGSLLALNSMFDQLSGVENSGN 834
            ..          .|.|...|:.:..|..:.:...||.|:..|           .:.:|.:.|.
Mouse   643 ATSFSQPEGESFSKIEPPSESRKAEPCPLKEEEKPQKEKPEP-----------LEPVSSLTNG-- 694

  Fly   835 NNSGHCFNNNNSCSSVSAQKPKAHPLAALQK-----LCETTDPPSTGLRSASSAGSSTASATLPS 894
                 |...|:     :...|..:||:|||.     |.:.|:|    |||.|.  ||..|:|.|.
Mouse   695 -----CAPANH-----TPALPSINPLSALQSVLNNHLGKATEP----LRSPSC--SSPNSSTSPV 743

  Fly   895 ANGNDLVAFSWACNEAVLSASNGGSAGDSSIIKCSYCDTPFASKGAYRHHLSKVHFVKDAGEDSP 959
            .:.:.|    ...::.|:|.::               ..|.||  ..||:|.:   ..|...|..
Mouse   744 FHKSSL----HVVDKPVISPTS---------------TRPAAS--VARHYLFE---NTDQPIDLT 784

  Fly   960 RLKSPAVQSPRSMPLASP----------------RRSASRSPATGSQQPP 993
            :.||...:|.::....||                .::.:..||..|:.||
Mouse   785 KSKSKRAESSQAQSCTSPPQKHALCDIADMVKVLPKATTPKPAASSRVPP 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tio	NP_001260679.1	zf-C2H2_2	<317..>344	CDD:289522	12/26 (46%)
		C2H2 Zn finger	319..341	CDD:275371	10/21 (48%)
		C2H2 Zn finger	428..450	CDD:275371	11/21 (52%)
		zf-C2H2_4	927..949	CDD:290605	6/21 (29%)
Tshz2	XP_006499486.2	C2H2 Zn finger	238..260	CDD:275371	10/21 (48%)
		C2H2 Zn finger	298..320	CDD:275371	11/21 (52%)
		homeodomain	858..926	CDD:238039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CNCF
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8737
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.970