DRSC/TRiP Functional Genomics Resources

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Protein Alignment tio and TSHZ2

DIOPT Version :9

Sequence 1:NP_001260679.1 Gene:tio / 44272 FlyBaseID:FBgn0028979 Length:1024 Species:Drosophila melanogaster
Sequence 2:NP_775756.3 Gene:TSHZ2 / 128553 HGNCID:13010 Length:1034 Species:Homo sapiens


Alignment Length:1002 Identity:203/1002 - (20%)
Similarity:328/1002 - (32%) Gaps:352/1002 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 KRPKSHGDDDQEEDQEQDQEQEQEQEPDHDVQCDNG---PLDLSVSTGKRQESV----SPPARKI 208
            ||...:..::|.:::|:.:|:|:|::.....|...|   ..|..:.||..|:..    :.|...:
Human    10 KRAAGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHL 74

  Fly   209 PRSISADYKSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLA------PSEASKALEKMTEMSRLE 267
            ... .|:.:|.|...|      ..::.:.:..|.....|.|      |:||...::|||.:....
Human    75 SNQ-DAENESLLSDAS------DQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANI 132

  Fly   268 TSPTAARSLGATSSVGAGVPAGASSNSGGRHS--AWQSHWLNKGAD------------------- 311
            .|.:....||....:.........:.:|...|  .|....|:|...                   
Human   133 LSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQL 197

  Fly   312 ------------TAKDVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPT 364
                        |....|:|..|..::.||..||.||.||.|                       
Human   198 YRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGH----------------------- 239

  Fly   365 RLATSASNSACSSSSSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCM 429
                              ....|..|.:|.   ..:...|||.. .||:    ..|..:::||||
Human   240 ------------------YQDDNRKKDKLR---PTSYSKPRKRA-FQDM----DKEDAQKVLKCM 278

  Fly   430 WCGQSFRSLAEMTSHMQETQHYTNIISQEQIISWKSGDERERPTNTGVPSTSTA----------- 483
            :||.||.||.:::.||.:|:||..:                 |....||:.|:.           
Human   279 FCGDSFDSLQDLSVHMIKTKHYQKV-----------------PLKEPVPTISSKMVTPAKKRVFD 326

  Fly   484 --APSSPSCTAPSV------------------------------------SAVLTCKVCDQAFGS 510
              .|.||..|..|.                                    |.:|.|..|..:..:
Human   327 VNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDT 391

  Fly   511 LKELSTHMAQKSHYKESPAPSASPPAAGTGNPKRGRQNRNEKRKKSLPVRKLLELERSGSNSSLD 575
            |::|:|||....|:.:..: |||         |:|:|...:    .|.|.|:..|..:.::.|| 
Human   392 LQQLTTHMMVTGHFLKVTS-SAS---------KKGKQLVLD----PLAVEKMQSLSEAPNSDSL- 441

  Fly   576 SALKPLRDFAA-ATKITCE-KCGSK-------------IETALFVEHIRKCLGESIPIPPRRSNA 625
             |.||..:.|: .|..|.| |..||             :::..:.:.::|.|..:|.....|.  
Human   442 -APKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLRE-- 503

  Fly   626 GVDRLPSPSLGLGAEKPPSVLNALEQLI-------EKSFESRTSRTMTHGGYS-EAGT----PLG 678
              :.|...|.|.|     .:|.:||..:       :....|.::....|..|. ..||    |:|
Human   504 --EDLEDGSKGGG-----DILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMG 561

  Fly   679 ASILK-RLGIEDSSDYTKP---LMDAQAM--HL-----LRSSFASRDRSASESSSASRVE--SSY 730
            :.:|: |..:.:......|   :|...:|  ||     ::.....:|.:..|....|..|  ||:
Human   562 SQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSF 626

  Fly   731 TPDRQQATPHKSPDTPAPPPPPPPTIKAE--PL-EAEPLVGCDREGCSPRQQIQVKKEFSMEACR 792
            :        |...|:......||...|.|  || |.|.|:   :||                   
Human   627 S--------HSEGDSFRKSETPPEAKKTELGPLKEEEKLM---KEG------------------- 661

  Fly   793 ESPRSVSKSPAPQTERSPPDNGSLLALNSMFDQLSGVENSGNNNSGHCFNNNNSCSSVSAQKPKA 857
                |..:.|.|....|...||..||                          |...::    |..
Human   662 ----SEKEKPQPLEPTSALSNGCALA--------------------------NHAPAL----PCI 692

  Fly   858 HPLAALQK-----LCETTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWACNEAVLSASNG 917
            :||:|||.     |.:.|:|    |||.|.  ||.:|:|:...:.::|...    ::.|||.::.
Human   693 NPLSALQSVLNNHLGKATEP----LRSPSC--SSPSSSTISMFHKSNLNVM----DKPVLSPAST 747

  Fly   918 GSAGDSSIIKCSYCDTPFASKGAYRHHLSKVHFVKDAGEDSPRLKSPAVQSPRSMPLASP----- 977
            .||..|........|.|.                     |..:.||...:|.::....||     
Human   748 RSASVSRRYLFENSDQPI---------------------DLTKSKSKKAESSQAQSCMSPPQKHA 791

  Fly   978 -----------RRSASRSPATGSQQPP 993
                       .::.:..||:.|:.||
Human   792 LSDIADMVKVLPKATTPKPASSSRVPP 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tioNP_001260679.1 zf-C2H2_2 <317..>344 CDD:289522 12/26 (46%)
C2H2 Zn finger 319..341 CDD:275371 10/21 (48%)
C2H2 Zn finger 428..450 CDD:275371 11/21 (52%)
zf-C2H2_4 927..949 CDD:290605 2/21 (10%)
TSHZ2NP_775756.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..90 18/86 (21%)
C2H2 Zn finger 217..239 CDD:275371 10/21 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..265 7/70 (10%)
C2H2 Zn finger 277..299 CDD:275371 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..496 15/65 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..676 23/111 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..789 7/46 (15%)
homeodomain 842..910 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1014..1034
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146852
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2CNCF
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 98 1.000 Inparanoid score I5022
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8503
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12487
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4785
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.970

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