DRSC/TRiP Functional Genomics Resources

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Protein Alignment tio and TSHZ2

DIOPT Version :10

Sequence 1:NP_524733.2 Gene:tio / 44272 FlyBaseID:FBgn0028979 Length:1024 Species:Drosophila melanogaster
Sequence 2:NP_775756.3 Gene:TSHZ2 / 128553 HGNCID:13010 Length:1034 Species:Homo sapiens


Alignment Length:1002 Identity:203/1002 - (20%)
Similarity:328/1002 - (32%) Gaps:352/1002 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 KRPKSHGDDDQEEDQEQDQEQEQEQEPDHDVQCDNG---PLDLSVSTGKRQESV----SPPARKI 208
            ||...:..::|.:::|:.:|:|:|::.....|...|   ..|..:.||..|:..    :.|...:
Human    10 KRAAGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHL 74

  Fly   209 PRSISADYKSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLA------PSEASKALEKMTEMSRLE 267
            ... .|:.:|.|...|      ..::.:.:..|.....|.|      |:||...::|||.:....
Human    75 SNQ-DAENESLLSDAS------DQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANI 132

  Fly   268 TSPTAARSLGATSSVGAGVPAGASSNSGGRHS--AWQSHWLNKGAD------------------- 311
            .|.:....||....:.........:.:|...|  .|....|:|...                   
Human   133 LSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQL 197

  Fly   312 ------------TAKDVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPT 364
                        |....|:|..|..::.||..||.||.||.|                       
Human   198 YRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGH----------------------- 239

  Fly   365 RLATSASNSACSSSSSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCM 429
                              ....|..|.:|.   ..:...|||.. .||:    ..|..:::||||
Human   240 ------------------YQDDNRKKDKLR---PTSYSKPRKRA-FQDM----DKEDAQKVLKCM 278

  Fly   430 WCGQSFRSLAEMTSHMQETQHYTNIISQEQIISWKSGDERERPTNTGVPSTSTA----------- 483
            :||.||.||.:::.||.:|:||..:                 |....||:.|:.           
Human   279 FCGDSFDSLQDLSVHMIKTKHYQKV-----------------PLKEPVPTISSKMVTPAKKRVFD 326

  Fly   484 --APSSPSCTAPSV------------------------------------SAVLTCKVCDQAFGS 510
              .|.||..|..|.                                    |.:|.|..|..:..:
Human   327 VNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDT 391

  Fly   511 LKELSTHMAQKSHYKESPAPSASPPAAGTGNPKRGRQNRNEKRKKSLPVRKLLELERSGSNSSLD 575
            |::|:|||....|:.:..: |||         |:|:|...:    .|.|.|:..|..:.::.|| 
Human   392 LQQLTTHMMVTGHFLKVTS-SAS---------KKGKQLVLD----PLAVEKMQSLSEAPNSDSL- 441

  Fly   576 SALKPLRDFAA-ATKITCE-KCGSK-------------IETALFVEHIRKCLGESIPIPPRRSNA 625
             |.||..:.|: .|..|.| |..||             :::..:.:.::|.|..:|.....|.  
Human   442 -APKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLRE-- 503

  Fly   626 GVDRLPSPSLGLGAEKPPSVLNALEQLI-------EKSFESRTSRTMTHGGYS-EAGT----PLG 678
              :.|...|.|.|     .:|.:||..:       :....|.::....|..|. ..||    |:|
Human   504 --EDLEDGSKGGG-----DILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMG 561

  Fly   679 ASILK-RLGIEDSSDYTKP---LMDAQAM--HL-----LRSSFASRDRSASESSSASRVE--SSY 730
            :.:|: |..:.:......|   :|...:|  ||     ::.....:|.:..|....|..|  ||:
Human   562 SQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSF 626

  Fly   731 TPDRQQATPHKSPDTPAPPPPPPPTIKAE--PL-EAEPLVGCDREGCSPRQQIQVKKEFSMEACR 792
            :        |...|:......||...|.|  || |.|.|:   :||                   
Human   627 S--------HSEGDSFRKSETPPEAKKTELGPLKEEEKLM---KEG------------------- 661

  Fly   793 ESPRSVSKSPAPQTERSPPDNGSLLALNSMFDQLSGVENSGNNNSGHCFNNNNSCSSVSAQKPKA 857
                |..:.|.|....|...||..||                          |...::    |..
Human   662 ----SEKEKPQPLEPTSALSNGCALA--------------------------NHAPAL----PCI 692

  Fly   858 HPLAALQK-----LCETTDPPSTGLRSASSAGSSTASATLPSANGNDLVAFSWACNEAVLSASNG 917
            :||:|||.     |.:.|:|    |||.|.  ||.:|:|:...:.::|...    ::.|||.::.
Human   693 NPLSALQSVLNNHLGKATEP----LRSPSC--SSPSSSTISMFHKSNLNVM----DKPVLSPAST 747

  Fly   918 GSAGDSSIIKCSYCDTPFASKGAYRHHLSKVHFVKDAGEDSPRLKSPAVQSPRSMPLASP----- 977
            .||..|........|.|.                     |..:.||...:|.::....||     
Human   748 RSASVSRRYLFENSDQPI---------------------DLTKSKSKKAESSQAQSCMSPPQKHA 791

  Fly   978 -----------RRSASRSPATGSQQPP 993
                       .::.:..||:.|:.||
Human   792 LSDIADMVKVLPKATTPKPASSSRVPP 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tioNP_524733.2 zf-C2H2 317..337 CDD:395048 8/19 (42%)
C2H2 Zn finger 319..341 CDD:275371 10/21 (48%)
C2H2 Zn finger 428..450 CDD:275371 11/21 (52%)
zf-C2H2_4 927..949 CDD:464025 2/21 (10%)
TSHZ2NP_775756.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..90 18/86 (21%)
C2H2 Zn finger 217..239 CDD:275371 10/21 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..265 7/70 (10%)
C2H2 Zn finger 277..299 CDD:275371 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..496 15/65 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..676 23/111 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..789 7/46 (15%)
homeodomain 842..910 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1014..1034
Blue background indicates that the domain is not in the aligned region.

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