DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tio and Tshz1

DIOPT Version :9

Sequence 1:	NP_001260679.1	Gene:	tio / 44272	FlyBaseID:	FBgn0028979	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_001074769.1	Gene:	Tshz1 / 110796	MGIID:	1346031	Length:	1084	Species:	Mus musculus

Alignment Length:	1086	Identity:	226/1086 - (20%)
Similarity:	347/1086 - (31%)	Gaps:	376/1086 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 QQA-------VVEGEVESPALDFSRKRPKSHGDDD------QEEDQEQDQEQEQEQEPDHDVQCD 184
            |||       |.|.|:::..:|      :.|.:|.      ||.:...::|.|.::...:    .
Mouse     6 QQAPRRSAAYVPEEELKAAEID------EEHAEDGGLSLDIQESEFACNEETEIKEAQSY----Q 60

  Fly   185 NGPLDLSVSTGKRQESVSPPARKIPRSISADYKSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLA 249
            |.|    |||...|:              |.|.||...||                     .:||
Mouse    61 NSP----VSTATNQD--------------AGYGSPFSEGS---------------------DQLA 86

  Fly   250 PSEASKALEKMTEMSRLETSPTAARSLGATSSVGAGVPAGASSNSGGRHSAWQSHWLNKGADTAK 314
            ..::|.:.|:..|....::......||....:|.|.:.:         .|.|.|        .|.
Mouse    87 HFKSSSSREEKEESQCPDSVSYPQDSLAQIKAVYANLFS---------ESCWSS--------LAL 134

  Fly   315 DVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSPLPTGGVGTPSAPPPTRLATSASNSA----- 374
            |:      |:|.|..:|..|..||:                .||:..|||..|::|..:|
Mouse   135 DL------KKSNSATSNNDASQKES----------------STPTPTPPTSTASTACTTATTAIT 177

  Fly   375 -CSSSSSSTSSSSNSSKS-------ELNMLIKET-----MPLPR-----KLVRGQDVWLGK---G 418
             ||:|:|.:|::||||.|       .|...:::|     :|.|.     :|.|..:...|.   |
Mouse   178 SCSTSTSHSSTTSNSSSSGYDWHQAALAKTLQQTSSYGLLPEPSLFSTVQLYRQNNKLYGSVFTG 242

  Fly   419 AEQTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNIISQEQIISWKSGDERERPTNTGVPSTSTA 483
            |.:.|    |..|..::.:|.|:|.||.||.||.:             |.|::      .|..|.
Mouse   243 ASKFR----CKDCSAAYDTLVELTVHMNETGHYRD-------------DNRDK------DSEKTK 284

  Fly   484 APSSPSCTA-------PSVSAVLTCKVCDQAFGSLKELSTHMAQKSHYKESP------------- 528
            ..|.|...:       .....||.|..|..:|.||::||.||.:..||::.|
Mouse   285 RWSKPRKRSLMEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVPAITKLVP 349

  Fly   529 ----------APSASPPAAG---------------TGNP------KRGRQN------RNEKRKKS 556
                      |...||...|               |.||      :.|.||      :.|.||..
Mouse   350 STKKRALQDLASPCSPEPTGVATEVALSESAKDQKTANPYVTPNNRYGYQNGASYTWQFEARKAQ 414

  Fly   557 LPVRKLLELERSGSNSSLDSALKPLRDFAAATKITCEKCGSKIETALFVEHIRKCLGESIPIPP- 620
            :    |..:|...|:.:|......:.......|:|..  .||....|.::.:.:...:|||:||
Mouse   415 I----LKCMECGSSHDTLQQLTAHMMVTGHFLKVTTS--ASKKGKQLVLDPVVEEKIQSIPLPPT 473

  Fly   621 ---RRSNAGVDRLPSPSLGLGA-------------EKPPSVLNALEQLIEKSFESRTSRTMTHGG 669
               |...:.:.:.|....|..|             ||.|......|:.|::..|..|.:......
Mouse   474 THTRLPASSIKKQPDSPAGSVASEEKKEPEKEKEKEKAPPAAGDAERKIKEETEDATEKFEPTAL 538

  Fly   670 Y----------SEAGTPLGASILKRL-------------GIEDSSDY------------TKPLMD 699
            |          |..|   |..|||.|             |......|            .|||..
Mouse   539 YQYLREEDLDDSPKG---GVDILKSLENTVSTAISKAQNGAPSWGGYPSIHAAYQLPGTVKPLQS 600

  Fly   700 AQAMHLLRSSFASRDRSASESSSASRVES--SYTPDRQQATPHKSPDTPAPPPPPPPTIKAEPLE 762
            |.....::.|:||..:|.|.:...:.:.|  |.||     .||||            .:.|....
Mouse   601 AVQSVQIQPSYASSVKSLSSTEHNALLHSPGSLTP-----PPHKS------------NVSAMEEL 648

  Fly   763 AEPLVGCDREGCSPRQQIQVKKEFSMEACRESPRSVSKSPAPQTERS---PPDNGSLLALNSMFD 824
            .|.:.|   :....:::...:||.|......||.:......|:||.:   |...||        |
Mouse   649 VEKVTG---KVSIKKEERPTEKEKSSPVKAISPVAKENKDLPKTEETGSKPQKKGS--------D 702

  Fly   825 QLSGVENSGNNNSGHCFNN--------NNSCSSV------SAQKPKAHPLAALQKLCETTDPPST 875
            ..:|.....:....|..|.        .|.|..:      |.:....:||:|||.:..|
Mouse   703 SETGKAKKESTLDAHTPNGTEPLKAKVTNGCGHLGIITDHSPEPSFINPLSALQSIMNT------ 761

  Fly   876 GLRSASSAGSSTASATLPSANGNDLVAFSWACNEAVLSASNGGSAGDSSIIKCSYCDTPFASKGA 940
                      .....:.|.:...|.:|..:..:.::|.             |..|..||.....|
Mouse   762 ----------HLGKVSKPVSPSLDPLAMLYKISNSMLD-------------KPVYPTTPAKQADA 803

  Fly   941 -----YRHHLSKVHFVKDAGEDSPRLKSPAVQSP------------------RSMPLAS-PRRSA 981
                 |.:....:...|...:......:.||.||                  |..|.:| |...:
Mouse   804 IDRYYYENSDQPIDLTKSKNKPLVSGVADAVSSPLRESALMDISDMVKNLTGRLTPKSSTPSTVS 868

  Fly   982 SRSPATGSQQPPPSPTISPYDE--------SPQSKFLKYTELAKQL 1019
            .:|.|.||........:||..:        :||...:...:.|..|
Mouse   869 EKSDADGSSFEEALDELSPVHKRKGRQSNWNPQHLLILQAQFASSL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tio	NP_001260679.1	zf-C2H2_2	<317..>344	CDD:289522	7/26 (27%)
		C2H2 Zn finger	319..341	CDD:275371	7/21 (33%)
		C2H2 Zn finger	428..450	CDD:275371	9/21 (43%)
		zf-C2H2_4	927..949	CDD:290605	6/26 (23%)
Tshz1	NP_001074769.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..108		19/101 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..167		11/42 (26%)
		C2H2 Zn finger	248..270	CDD:275371	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..298		8/47 (17%)
		C2H2 Zn finger	309..331	CDD:275371	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..534		16/66 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..728		16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..879		8/23 (35%)
		homeodomain	892..960	CDD:238039	4/23 (17%)
		zf-C2H2_2	976..>1067	CDD:372293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836799
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I4987
Isobase	1	0.950	-	0	Normalized mean entropy	S7006
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8737
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.990