DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tio and tshz2

DIOPT Version :9

Sequence 1:	NP_001260679.1	Gene:	tio / 44272	FlyBaseID:	FBgn0028979	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_002935441.3	Gene:	tshz2 / 100497744	XenbaseID:	XB-GENE-486894	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	968	Identity:	191/968 - (19%)
Similarity:	313/968 - (32%)	Gaps:	306/968 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 GD---DDQEEDQEQD---QEQEQEQEPDHDVQCDNGPLDLSV------------STGKRQESVSP 203
            ||   ||:|||.:.:   |:|:....|..:.|...|.|..|.            ..|:.:..||.
Frog    24 GDEMKDDEEEDDDSNSIAQQQDSSYSPTDEEQEIGGELKRSFGYQSSPGSHLCNQDGESESVVSD 88

  Fly   204 PARKIPRSISADYKSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLAPSEASKALEKMTEMSRLET 268
            .:.|     .:|.|.|....:..|..:|                 ||...::..:.|.:|.
Frog    89 SSDK-----GSDIKGPSSKDAQDPKTSP-----------------APKPQAEGHDCMNKMK---- 127

  Fly   269 SPTAARSLGATS-----SVGAGVPAGASSNSGGRHSA------WQSHWLNKGAD----------- 311
              ||..::.:.|     .:...||.........|:.|      |....|:|...
Frog   128 --TAYANILSDSYWERIGLNVKVPHSERKVCESRNGASKTDFDWHQDALSKSLQQNLPSKSVSKP 190

  Fly   312 --------------------TAKDVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSPLPTGGVG 356
                                |....|:|..|..::.||..||.||.||.|
Frog   191 NLFSSVQLYRQNAKMYGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGH--------------- 240

  Fly   357 TPSAPPPTRLATSASNSACSSSSSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQDVWLGKGAEQ 421
                    ....:.....|.|:|.|.|.                    ::.....|      .|.
Frog   241 --------YQDDNRKKDKCISTSYSKSR--------------------KRAFHDMD------KED 271

  Fly   422 TRQILKCMWCGQSFRSLAEMTSHMQETQHYTNIISQEQIISWKS---GDERERPTNTGVPSTSTA 483
            .:::||||:||.||.||.:::.||.:|:||..:..:|.|.:..|   ...|:|       .....
Frog   272 AQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPIPTLSSKLVSPARKR-------VFEAT 329

  Fly   484 APSSPSCTAPSV------------------------------------SAVLTCKVCDQAFGSLK 512
            .|.||..|..|.                                    |.:|.|..|..:..:|:
Frog   330 RPCSPDSTTGSFGDHGSSHKNGSVQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQ 394

  Fly   513 ELSTHMAQKSHYKESPAPSASPPAAGTGNPKRGRQNRNEKRKKSLPVRKLLELERSGSNSSLDSA 577
            :|:|||....|:.: ...|||         |:|:|...:    .|.|.|:..|..|..|   ||.
Frog   395 QLTTHMMVTGHFLK-VTNSAS---------KKGKQLVLD----PLAVEKMQSLSESSPN---DSP 442

  Fly   578 LKPLRDFAAATKI----TCEKC-------GSKIETALFVEHIRKCLGESIPIPPRRSNAGVDRLP 631
            .||..:..:.:..    .|::.       |:|.|.:...|.....:.:  |:.|   ......|.
Frog   443 SKPFTNSPSGSSTPELKACKESRSDNLEDGNKEEKSETSEEPEDAVEK--PLDP---TLKYQYLR 502

  Fly   632 SPSLGLGAEKPPSVLNALEQLIEKSFESRTSRTMTHGGYSEAGTPLGASILKRLGIEDSSDYTKP 696
            ...|..|:::...:|.:||..:..:...           ::.|||..::..........:|..||
Frog   503 EEDLDDGSKEGGDILKSLENTVTSAINK-----------AQNGTPSWSAYPSIHAAYQITDVIKP 556

  Fly   697 --LMDAQAMHLLRSSFASRDRS-ASESSSASRVESSYTPDRQQATPHKSPDTPAPPPPPPPTIKA 758
              .:..|.|. :|::|:::.|. |.:|.|.|.|.:         |||:...|...........:.
Frog   557 SVSLGTQVMQ-MRNTFSNKFRPIAPKSKSVSHVPN---------TPHELQSTQVKEESEVKEDQK 611

  Fly   759 EPLEAEPLVGCDREGCSPRQQIQVKKEFSMEACRESPR---SVSKSPAPQTERSPPDNGSLLALN 820
            |..:....:..|::..||..|:..:......:|.|..:   :..|..|...|
Frog   612 ETTDDSETMSVDKDEDSPAVQVSCEATRRDSSCTEEEKIKQNCEKEKARIQE------------- 663

  Fly   821 SMFDQLSGVENSGNNNSGHCFNNNNSCSSVSAQKPKAHPLAALQKLCETTDPPSTGLRSASSAGS 885
            ||...||..:.|...:|.:|          |...|..:||:|||.:..            :..|.
Frog   664 SMEPSLSSNDCSALRSSANC----------SPDLPCVNPLSALQSVLN------------NHLGK 706

  Fly   886 STASATLPSANGNDLVAFSWACNEAVLSASNGGSAGDSSIIKCSYCDTPFASKGAYRHHLSKVHF 950
            :|.|.. |.|..|.:..|.    ::.::.|....|          |.||.....:|
Frog   707 ATESLR-PQACSNTIKIFP----KSTMNKSERPIA----------CLTPPRPVRSY--------- 747

  Fly   951 VKDAGE---DSPRLKSPAVQSPRSMPLASPRRSASRSPATGSQQPPPSPTISPYDESP 1005
            :.||.:   |..:.||..::|.::....||.:..:.|......:..|..| :|...:|
Frog   748 LFDANDQPIDLTKTKSKRLESAKAQSCTSPPQKHALSDIADMVKVLPKAT-TPKHAAP 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tio	NP_001260679.1	zf-C2H2_2	<317..>344	CDD:289522	12/26 (46%)
		C2H2 Zn finger	319..341	CDD:275371	10/21 (48%)
		C2H2 Zn finger	428..450	CDD:275371	11/21 (52%)
		zf-C2H2_4	927..949	CDD:290605	4/21 (19%)
tshz2	XP_002935441.3	homeodomain	833..901	CDD:238039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9401
Panther	1	1.100	-	-	LDO	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.130