DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tio and tshz2

DIOPT Version :9

Sequence 1:	NP_001260679.1	Gene:	tio / 44272	FlyBaseID:	FBgn0028979	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_005174183.3	Gene:	tshz2 / 100332862	-ID:	-	Length:	1028	Species:	Danio rerio

Alignment Length:	1122	Identity:	221/1122 - (19%)
Similarity:	346/1122 - (30%)	Gaps:	413/1122 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 FSRKRP-KSHGDDDQ-------EEDQEQDQEQEQEQEPDHDVQCDNGPLDLS-----------VS 193
            |||:|. |::..||:       ||::.::..|.:|:..:.....|....|:.           ||
Zfish    14 FSRQRQGKTYEPDDEVGVQESIEEEEGENAMQTEEENSERPTSKDKDDKDIDNKSSYSFQNSPVS 78

  Fly   194 TGKRQE-----SVSPPARKIPRSISADYKSPLPPGSWMPPINPYLAAVAAKTGGLGYSKLAPSEA 253
            ....||     .:|..:.::     :|:|:. ||||             .|......||| ..:.
Zfish    79 VLSNQEVELESRLSDGSDRL-----SDFKTS-PPGS-------------QKDTETQSSKL-KDDM 123

  Fly   254 SKALEKMTEMSRLETSPTAARSLGATSSV-GAGVPAGASSNSGGRHSA--WQSHWLNK------- 308
            ..:||||........|.:....:|....| ..|..|...|.:|...|.  |....|:|
Zfish   124 HSSLEKMRAAYANFLSDSYWSKIGLDLKVANTGSKANCDSTNGSTKSEFDWHQDALSKTLQQTLS 188

  Fly   309 -----------------------GA-DTAKDVFKCVWCKQSFSTLANLTAHMKETQHCGVQIPSP 349
                                   || .|....|:|..|..::.||..||.||.::.|
Zfish   189 PKPVSKPNLFSSVHLYRQNSKACGAVFTGASRFRCKDCSAAYDTLVELTVHMNKSGH-------- 245

  Fly   350 LPTGGVGTPSAPPPTRLATSASNSACSSSSSSTSSSSNSSKSELNMLIKETMPLPRKLVRGQDVW 414
                               ...::....:.:|||||.|..::..:|
Zfish   246 -------------------YQDDNHSRQNIASTSSSKNRKRNLQDM------------------- 272

  Fly   415 LGKGAEQTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNIISQEQI---------ISWKSGDERE 470
              :|.|..:::||||:||.||.||.:::.||.:|:||..:..:|.|         .:.|...|..
Zfish   273 --EGKEDAQKVLKCMFCGHSFDSLQDLSVHMIKTKHYQKVPLKEPIPVITPKLIPPAKKRAFEAT 335

  Fly   471 RP----TNTGVPSTSTAAPSSPSCTAPS------------------VSAVLTCKVCDQAFGSLKE 513
            ||    :.|||...:.|..||....||:                  .|.:|.|..|..:..:|::
Zfish   336 RPCSPDSTTGVSGYTDAQRSSGLANAPNNRYGYQNGASYTWQFETCKSQILKCMECGSSHDTLQQ 400

  Fly   514 LSTHMAQKSHY--------------------------------------KESPAPSA-------- 532
            |:|||....|:                                      |.||..:|
Zfish   401 LTTHMMVTGHFIKVTNSASKKGKQLALDPLAIEKMQTLAEPTVNELEGEKVSPKSTASGDSERAT 465

  Fly   533 ----SPPAAGTGNPKRGRQNRNEKRKK----SLPVRKLLELERSGSNSSLDSALKPLRDFAAATK 589
                ||..|.....|..:|:..|::..    ..|..:..:||:.||:...| .||.|.: ..|:.
Zfish   466 PRDMSPDKAEKNEDKDDKQDEEERKPTDGNFKYPYLREEDLEQQGSSGGGD-ILKSLAN-TVASA 528

  Fly   590 ITCEKCGS-------KIETALFVEHIRKCLGESIPIPPRRSNAGVDRLPSPSLGLGAEKPPSVLN 647
            |...:.|:       .|..|..:..:.|....| |.||.:....::....|....|  |....|.
Zfish   529 INKAQTGTPSWSAYPSIHAAYQLSGVIKTASFS-PSPPIQLKQNLNHKHRPIAPKG--KFYQALR 590

  Fly   648 ALE----------------------------QLIEK--------------------SFESRTSRT 664
            .||                            .|:|.                    |.|:.|.:.
Zfish   591 GLESFQGHHNSDIKKERGGASDGKESQSSRFDLVENDDSDCQDDSSSSSKLDADCVSEENDTIKG 655

  Fly   665 MTHGGYSEAGTPL-------GASILKRLGIEDSSDY--------------------TKPLMDAQA 702
            .....:|:.|.|.       |.|....| :.||.:.                    .||..::..
Zfish   656 KLSPAFSDRGNPSPSPPASNGHSTSSEL-VNDSQEVLSINPLSALQSVLNNHLGKANKPRPESIL 719

  Fly   703 MHLLRSSFASRDRSASESSSAS---RVESS--YTPDRQ--QATPHKS------------------ 742
            .|..:|.|:...|...:..|||   |..:|  :|.|.|  ..|.||.
Zfish   720 SHRTQSIFSELSRGLEKPLSASAAIRASNSFMFTNDDQPIDLTKHKHNKPNSSLLLQSSTPMHQK 784

  Fly   743 -------------PDTPAPPPPPP---PTIKA-------EPLEAEPLVGCDREG----CSPRQQI 780
                         |....|.||.|   |.:|.       |.:.:|......|:|    .:|:..:
Zfish   785 HALSDIADMVKVLPKATTPKPPMPARMPVMKLETDVRRFEDVSSEMYSVHKRKGRQSNWNPQHLL 849

  Fly   781 QVKKEFSMEACRESPRSVSKSPAPQTERSPPDNGSLLALNSMFDQLSGVE----NSG------NN 835
            .::.:|:....:.|......|.....||......:.|::.::...|:.|:    .:|      |.
Zfish   850 ILQAQFASSLFQTSEGKYLLSDLGPQERMHISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNM 914

  Fly   836 NSGHCFNNNNSCSSVSAQKPKA----------HPLAALQKL-----CETTDPPSTGLRSASSAGS 885
            ::||.....|.|:| ..:.|.|          ..:..:.||     .:.|:|..:.:.:.....|
Zfish   915 DTGHPVFYCNDCAS-QFRTPSAFISHLENHLGFQIKDMNKLPIEHPTKITEPELSKVLTIRPTDS 978

  Fly   886 STASATLPSANGNDLVAFSWACNEAVLSASNGGSAGDSSIIKCSYCDTPFASKGAYRHHLSKVHF 950
            ....                             ...||. .||..|...|||..|.:.||||.|
Zfish   979 QITE-----------------------------EESDSK-FKCKLCSRTFASNHAVKLHLSKTH- 1012

  Fly   951 VKDAGEDSPRLKSPAVQ 967
                 ..||...|..|:
Zfish  1013 -----SKSPENHSQFVE 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tio	NP_001260679.1	zf-C2H2_2	<317..>344	CDD:289522	10/26 (38%)
		C2H2 Zn finger	319..341	CDD:275371	8/21 (38%)
		C2H2 Zn finger	428..450	CDD:275371	11/21 (52%)
		zf-C2H2_4	927..949	CDD:290605	11/21 (52%)
tshz2	XP_005174183.3	homeodomain	837..905	CDD:238039	10/67 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CNCF
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4973
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6467
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.970