DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment xmas and SAC3

DIOPT Version :9

Sequence 1:	NP_001356948.1	Gene:	xmas / 44271	FlyBaseID:	FBgn0286809	Length:	2079	Species:	Drosophila melanogaster
Sequence 2:	NP_010443.3	Gene:	SAC3 / 851737	SGDID:	S000002566	Length:	1301	Species:	Saccharomyces cerevisiae

Alignment Length:	1367	Identity:	283/1367 - (20%)
Similarity:	504/1367 - (36%)	Gaps:	369/1367 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 VSRDRTPAQLRDLENMMRRPAHTS----EEKFSVLDARDKLLRLNRTQHKLSGAT--QGHCADMC 206
            :|.:.:...|.:|...:::..:|.    ||| .::|..|       :...|..|.  ||.|.|||
Yeast   148 ISLEESIDDLNELYETLKKMRNTERSIMEEK-GLVDKAD-------SAKDLYDAIVFQGTCLDMC 204

  Fly   207 PEKERVLREFQRQVAYYELQPGSDELICHERALKQYSRSSADQETPLPHELRNETALHMTMSYLM 271
            |..||..|..:..|..||....:|:.....:|||.::|.:|....|||.::|....|..|:.|::
Yeast   205 PTFERSRRNVEYTVYSYEKNQPNDKKASRTKALKVFARPAAAAAPPLPSDVRPPHILVKTLDYIV 269

  Fly   272 HEIMDISERQDPQSHMGDWFHFVWDRTRSIRKEITQQELCSLGAVKLVEQCARFHIHCAARLVDA 336
            ..::...    |:|.     .|:|||.||||::.|.|......||...|:..|.|:.....:|.:
Yeast   270 DNLLTTL----PESE-----GFLWDRMRSIRQDFTYQNYSGPEAVDCNERIVRIHLLILHIMVKS 325

  Fly   337 DPSVFDSKINAENLTKCLQTLKYMYHDLRIKGVPCPKEAEFRGYIVLLNLADANFLWDIGQLPAE 401
            :.. |..:...|.|.|.|.||..:|.|:|..|..||.|||||.|.:|..:.|..:..:|.:||..
Yeast   326 NVE-FSLQQELEQLHKSLITLSEIYDDVRSSGGTCPNEAEFRAYALLSKIRDPQYDENIQRLPKH 389

  Fly   402 LQSCPEVRQAIQFYLALQDT--------------NF-VRFFQLLADKDTSYLSACILVNYFTRLR 451
            :.....|:.|:.|...:.::              || .|||||:.......|....|..:.|.:|
Yeast   390 IFQDKLVQMALCFRRVISNSAYTERGFVKTENCLNFYARFFQLMQSPSLPLLMGFFLQMHLTDIR 454

  Fly   452 VLGLHRLIQAYRSPRKDEVSSLPLSYIAELLSFASEQEAADFVQHYGLQINEAGRVVLSRM---- 512
            ...|..|........|    .:|..|:..:|.|.:.||..:|..:|.::|.......|..:
Yeast   455 FYALRALSHTLNKKHK----PIPFIYLENMLLFNNRQEIIEFCNYYSIEIINGDAADLKTLQHYS 515

  Fly   513 HTVETEYKLPRQYELVEVKRVKSV---GEVVSGEPLPPRDLYL----NHRPHNSFDDYGMLKSIA 570
            |.:.....|.:.|.....:|::..   |.:..||......:|:    ..|..:..|...::::..
Yeast   516 HKLSETQPLKKTYLTCLERRLQKTTYKGLINGGEDNLASSVYVKDPKKDRIPSIADQSFLMENFQ 580

  Fly   571 WTAKDQLAGMQQEEMQPQMPSQPPAVSKHSDTLFKVPMQPDGTAAGFGVFAAAAVPPASSIDGFS 635
            ....::|  .|...::||:.:.|..|:...:   ..|...:          :..:|..|.    |
Yeast   581 NNYNEKL--NQNSSVKPQINTSPKRVATRPN---HFPFSQE----------SKQLPQISQ----S 626

  Fly   636 FVLPKSRAQEFQEQAPATQQRRAQEEAK-----------HQALQVAIAAAKKREAELMAIHEAKV 689
            ..|..:.....|.....::|:  |::.|           .|:.|.:...|.|  |.:::
Yeast   627 HTLSTNPLLTPQVHGDLSEQK--QQQIKTVTDGGSPFVFDQSAQNSTVEASK--AHMIS------ 681

  Fly   690 AEAERVRQQKLRERQEQQRRQQQELEEQRQREQEKLQLEKERQLKLEQLFFVQQQEREAHKQTRT 754
            ..:.....:||...||:.|::    |||| .|:||.||:|:::              .|.||..|
Yeast   682 TTSNGAYDEKLSSEQEEMRKK----EEQR-IEEEKTQLKKKQE--------------NADKQVIT 727

  Fly   755 ----LELYQEIFQDTLAEICQSEFMSHSRACRSY-ESMLDSITRDLVERQMEQSIYELGVMRVCI 814
                .:|.:|:...::..|.:.||   |.|  :| :..:|::||:|.:..:.:.:|     .:.:
Yeast   728 EQIANDLVKEVVNSSVISIVKREF---SEA--NYRKDFIDTMTRELYDAFLHERLY-----LIYM 782

  Fly   815 RRWRKYRRTQQEKDTLFNQLPLSFGAENPEGVVNKRSMEDSLRLSRRYRLGEPCDYGKLLAGLEE 879
            ....:.:|....|...|.:...|:.......::.::..|:...:|  ::||.|        |.::
Yeast   783 DSRAELKRNSTLKKKFFEKWQASYSQAKKNRILEEKKREEIKLVS--HQLGVP--------GFKK 837

  Fly   880 HSWLKLDLWHVLDKCLPVAQPGARRFYKLLISLSGGQEGLQLNCDLDRGLLQQPQSPDARFVDGG 944
            .:            ||      .|..||      |......:....|:.|:..|.
Yeast   838 ST------------CL------FRTPYK------GNVNSSFMLSSSDKNLIFSPV---------- 868

  Fly   945 YIRGFSQGIGLSVMKIRDDDHDWKATDLAEANGIICLIGLDDIRLLPDRLKPLLQASRCHDVAVI 1009
                             :|:.:..||.|.:.:.:               .:||...|..:| .:.
Yeast   869 -----------------NDEFNKFATHLTKISKL---------------WRPLEMQSIYYD-NLT 900

  Fly  1010 VQHPANTAFVQPDIPLQELCLRSFNIFRLRK---SGNNRQRLMIALESAVKF-LAKATERKRVGH 1070
            .:.|:|:             |...|:|...|   |.:||..|.       || |..|.:.|:..:
Yeast   901 KKFPSNS-------------LTPANLFIYAKDWTSLSNRWILS-------KFNLQTAQDSKKFSN 945

  Fly  1071 LHQVETREYLLVNLGSELFRRLKYAAEHDTAIRSDTQL--------NPQRCVDLFNEAVHRLQLV 1127
                        |:.|.  |.:....|::.:..||.||        ||    |:|:     |::.
Yeast   946 ------------NIISS--RIICIDDEYEPSDFSDLQLLIFNTGVTNP----DIFD-----LEMK 987

  Fly  1128 AGEDLSDWPQFPEELRVFVQPLPIESSLNTN-----RLEHFEPGWHLPERRQRIVQLLERCKLPK 1187
            ..:|       .|||...:..:    |||||     .:.::|..
Yeast   988 LKDD-------GEELIKLITGI----SLNTNICFSLLIIYWESA--------------------- 1020

  Fly  1188 MPVLPRSSSLAEAQCQWVLDYAQISQQ-EDCVEQIALQAI------KILQYDTDDYLNFVEYLAG 1245
                  .::|:|:..:.:|...:||:. ...:|:|.|..:      |.|:....:..:...|...
Yeast  1021 ------ENTLSESTIKHLLKLNRISKNYSSVIERIDLMNLTEESPHKCLEDKLSEISHSYVYKLT 1079

  Fly  1246 ERMQYILRQERNPPQGIVYNTKTLK-RRFLSAWYYEFREPQIYEPVPAEENAQMLEKQPSSQAEV 1309
            ||.:|               .|||: :|.|:..:....:.|..:.:. ::..:||||:.:
Yeast  1080 ERGKY---------------DKTLRQKRSLAGIHSRSTQLQTTKDID-QKMKKMLEKEKN----- 1123

  Fly  1310 QQLDFDEITSKAEAVLKRFHQRQDERHTLREL----NRSHKSRKRRDASDHKHAMSSLVSALKAA 1370
                             ::.|:..||:|...|    :.|.:|:||:.......:.||......|:
Yeast  1124 -----------------KYQQQIGERNTYAHLESHIDASPRSKKRKLPILLSTSHSSQFKTPLAS 1171

  Fly  1371 RSDYQGKSSAVCRLVAQMVEADQVKYQWTPNLTSLIDRKDASTRHQWRPHVNHSTRHARKLPVQS 1435
            |.:..|.|::. .|.:.:.    :|::....:|||......||           ..|:..:|..|
Yeast  1172 RLNTSGSSTSP-PLPSHLA----MKFRKNSRVTSLHTVLPVST-----------PSHSNNIPAAS 1220

  Fly  1436 IS 1437
            .|
Yeast  1221 FS 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xmas	NP_001356948.1	RRM_XMAS2	12..82	CDD:240903
		SAC3_GANP	200..503	CDD:335312	93/317 (29%)
		DUF5401	<638..>827	CDD:340095	43/204 (21%)
SAC3	NP_010443.3	SAC3	103..812	CDD:227411	172/743 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I1184
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003569
OrthoInspector	1	1.000	-	-		oto100248
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12436
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1280
SonicParanoid	1	1.000	-	-		X2919
TreeFam	0	0.000	Not matched by this tool.
	7	7.040