DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment xmas and SPCC576.05

DIOPT Version :9

Sequence 1:	NP_001356948.1	Gene:	xmas / 44271	FlyBaseID:	FBgn0286809	Length:	2079	Species:	Drosophila melanogaster
Sequence 2:	NP_588432.1	Gene:	SPCC576.05 / 2539561	PomBaseID:	SPCC576.05	Length:	1024	Species:	Schizosaccharomyces pombe

Alignment Length:	807	Identity:	180/807 - (22%)
Similarity:	326/807 - (40%)	Gaps:	169/807 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 RNEYGSGKPIKKPQNGSSGSGGSSMLPAIPVGPATAPVSRDRTPAQLRDLE---NMMRRPAHTSE 172
            |||.|:.:..:....|.|......  .::...|....|..|.| :...|:|   :..:|.:.|.|
pombe     4 RNETGNNRLKRSNNRGKSKKDWKD--ASVETTPRETSVDEDNT-SVFEDVEAQDSRQKRFSSTLE 65

  Fly   173 ----EKFSVLDARDKLLRLNR-------TQHKLSGATQ--GHCADMCPEKERVLREFQRQVAYYE 224
                |:...|..:::.:.:..       ...:|..|..  |.|.|||||.||..||:|..:..:|
pombe    66 GNRFEELRSLREKEREVAIQNGLIDDPTKPRQLDEAVTFVGTCPDMCPEYEREQREYQNNLERWE 130

  Fly   225 LQPGSDELICHERALKQYSRSSADQETPLPHELRNETALHMTMSYLMHEIMDISERQDP--QSHM 287
            :.|.:.. :....|:|.:.|.:|..|..||.::|....|..::.||:.:|:.   ..||  .:|.
pombe   131 INPETGR-VDKNLAVKAFHRPAAGNEQALPSDVRPPPVLKKSLDYLVDKIVC---GPDPLENTHF 191

  Fly   288 GDWFHFVWDRTRSIRKEITQQELCSLGAVKLVEQCARFHIHCAARLVDADPSVFDSKINAENLTK 352
                 ||.|||||||::.|.|....|.||...|:.||:||.|..:|  .:...|.::...|.|.|
pombe   192 -----FVRDRTRSIRQDFTLQNCRDLDAVACHERIARYHILCIHQL--CEKKQFSAQQEVEQLRK 249

  Fly   353 -CLQTLKYMYHDLRIKGVPCPKEAEFRGYIVLLNLADANFLWDIGQLPAELQSCPEVRQAIQFYL 416
             .||:|...|.|||...:.||.|.|||.|.::.:|.|.:.:.....||.|:.....|:.|::...
pombe   250 GILQSLCEFYDDLRKVKIRCPNEPEFRSYAIITHLRDPDVVRQSQILPIEIFDDQRVQLALRLSA 314

  Fly   417 ALQDTN-----------------FVRFFQLLADKDTSYLSACILVNYFTRLRVLGLHRLIQAYRS 464
            ..|..|                 :.|||:|:.....:||.||:|.::|..:|...|..:.:|:.|
pombe   315 LAQKNNERVGHILPRNTEACPNLYTRFFKLVQSPAVTYLMACLLESHFMSIRKGALKAMRKAFMS 379

  Fly   465 PRKDEVSSLPLSYIAELLSFASEQEAADFVQHYGLQI-NEAGRVVLSRMHTV-----ETEYKLPR 523
            ..    ::.|...:..:|.|.:.::||.|.::|||:: ::.|.:.::...|.     :.:::...
pombe   380 AH----ANFPCGDLKRILHFDTVEQAASFSRYYGLEVSDDNGELSINLNKTAFFNDSKPDFRQLF 440

  Fly   524 QYELVEVK-RVKSVGEVVSG-----EPLPPRDLYLNHRPHNSFDDYGMLKSIAWTAKD--QLAGM 580
            ...|||.| :.:|..::::|     :.:.|...:..:.|          .|:.:..|:  .:||.
pombe   441 SQTLVESKLQNRSFADIINGSRYNIDRVSPNTAFSTNIP----------LSLPFANKEPQPIAGF 495

  Fly   581 QQEEMQPQMPSQPPAVSKHSDTL---FKV----------PMQPDGTAAGFGVFAAAAVPPAS--- 629
            ::...:..:      |||:..|.   |.|          |.:|      |.....::|.|.:
pombe   496 KKNTPETSV------VSKNLSTFNGKFNVNAPVFTPRSFPTKP------FSATDISSVQPTNLPN 548

  Fly   630 -SIDGFSFVLPKSRAQEFQEQAPATQQRRAQEEAKHQALQVAIAAAKKREAELMAIHEAKVAEA- 692
             |.:|....:|       ..|...|..:.|.:..|::...::..:       |.|:....::::
pombe   549 GSTNGTETFIP-------PVQNSITSNKEAVKPIKNKPKPISFES-------LSAVGNLIISDSL 599

  Fly   693 ERVRQQKLRERQEQQRRQQQEL---------------------------------------EEQR 718
            .|:.:|.|:....:...::..|                                       ....
pombe   600 SRIVRQILQNLYTEWVHEKTNLVFATMFRTIFREVLLDGIASEVYLKSLKKHAISQISVRAHHSW 664

  Fly   719 QREQEKLQLEKERQLKLEQLFFVQQQEREAHKQTRT-LELYQEIFQDT--LAEICQSEFMSHSRA 780
            .::|||:.||...:.:.|:.|.|.....:|.....| |.:.:..:.||  |.:..:.....|.|.
pombe   665 VKKQEKMMLEMREKNRQEKYFSVLNSVVKAESSNITRLPIKRTFYGDTRNLDKASEKLRAEHDRT 729

  Fly   781 CRSYESML-DSITRDLVERQMEQSIYE 806
            .|.::.:| ||:..:|    .:..:||
pombe   730 RRLWKPVLMDSLFSNL----QKFPVYE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xmas	NP_001356948.1	RRM_XMAS2	12..82	CDD:240903
		SAC3_GANP	200..503	CDD:335312	100/323 (31%)
		DUF5401	<638..>827	CDD:340095	34/213 (16%)
SPCC576.05	NP_588432.1	SAC3	15..686	CDD:227411	159/724 (22%)
SPCC576.05	NP_588432.1	SAC3_GANP	158..395	CDD:281402	74/250 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	142	1.000	Domainoid score	I1184
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003569
OrthoInspector	1	1.000	-	-		otm47398
orthoMCL	1	0.900	-	-		OOG6_103177
Panther	1	1.100	-	-	O	PTHR12436
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1280
SonicParanoid	1	1.000	-	-		X2919
TreeFam	0	0.000	Not matched by this tool.
	8	7.940