DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment xmas and mcm3ap

DIOPT Version :9

Sequence 1:	NP_001356948.1	Gene:	xmas / 44271	FlyBaseID:	FBgn0286809	Length:	2079	Species:	Drosophila melanogaster
Sequence 2:	XP_004917948.2	Gene:	mcm3ap / 100490007	XenbaseID:	XB-GENE-981006	Length:	2384	Species:	Xenopus tropicalis

Alignment Length:	1741	Identity:	452/1741 - (25%)
Similarity:	717/1741 - (41%)	Gaps:	393/1741 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIPELFLDKYVARSHFGRFGTLVNFVLRPRRMTCTVSYASEDEAARALLDGASFQGHLFDISYAD 82
            |:|.....|......|.:.|.:.....:|.|....:.:.:...||.|..........:....|..
Frog   815 NLPNHLNQKQYLEKFFKKAGKVQRMYCKPARKIAVIHFNNHTAAANAKKMAKKLHSDVCIFYYKK 879

  Fly    83 NETAPAQKTEEWVDPDIQAELSALQSGWRNEYGSGK------PIKK--PQNGSSGSGGSSMLPAI 139
            ..|:|.:|.|.....:.|.|       .|.|..||:      |::|  .::.::|:|..:..|..
Frog   880 KTTSPGKKGEFLSKSEQQIE-------EREERLSGEESTKLSPMRKRLVRDITTGTGAKTSPPKK 937

  Fly   140 P-----------VGPATAPVSRDRTPAQLRDLENMMRRPAHTSEEKFSVLDARDKLL---RLNRT 190
            |           ...|..|.|.....|....|.:::...|.:||:|:.:|:.|||:|   |:.||
Frog   938 PGFSKALHFDVESSDAQRPPSDSSGIALPPSLSHLLGLVAESSEDKYLLLNQRDKILRQARVKRT 1002

  Fly   191 QHKLSGATQGHCADMCPEKERVLREFQRQVAYYELQPGSDELICHERALKQYSRSSADQETPLPH 255
            :...:....|.|.||||||||.:||.::|::.:||.||:|: :.|..|:|:|||||||||.|||:
Frog  1003 ELDQAKLFVGTCPDMCPEKERYMRETRKQLSIFELLPGTDK-VDHATAIKEYSRSSADQEEPLPY 1066

  Fly   256 ELRNETALHMTMSYLMHEIMDISERQDPQSHMGDWFHFVWDRTRSIRKEITQQELCSLGAVKLVE 320
            |||....|.|||.||:.:|||..|     .:..:|:.|||:|||.|||:||||.||:|..|.|:|
Frog  1067 ELRPTHVLSMTMDYLVTQIMDKGE-----GNYREWYDFVWNRTRGIRKDITQQHLCNLSTVSLME 1126

  Fly   321 QCARFHIHCAARLVDADPSVFDSKINAENLTKCLQTLKYMYHDLRIKGVPCPKEAEFRGYIVLLN 385
            :|.|||||||..|.:...|.||:|||.|||||||.:||.||.||..:|:.||.|.|||||.|||:
Frog  1127 KCMRFHIHCAFELCEEPMSSFDAKINNENLTKCLLSLKEMYQDLHNRGISCPCEPEFRGYSVLLS 1191

  Fly   386 LADANFLWDIGQLPAELQSCPEVRQAIQFYLALQDTNFVRFFQLLADKDTSYLSACILVNYFTRL 450
            |...:.|.::.:..:.:....||:.|:|.:.||..|||||||:|:  :..|||::|||..||.::
Frog  1192 LNKGDILREVQEFHSTVLHSEEVKFAVQVFAALNSTNFVRFFKLI--RSASYLNSCILHRYFNQI 1254

  Fly   451 RVLGLHRLIQAYRSPRKDEVSSLPLSYIAELLSFASEQEAADFVQHYGLQINEAGRVVLSRMHTV 515
            |...|..|..|| :|.....:..||..:.::|.|....||.:|:..|||.::| |.|.|:|....
Frog  1255 RRDALRVLNVAY-TPSIQRPTLFPLESMLQMLFFQDTNEATEFLNSYGLSVSE-GNVELNRSAFF 1317

  Fly   516 ETE-YKLPRQYELVEVKRVKSVGEVVSGEPLPPRDLYLNHRPHNSFDDYGM-----------LKS 568
            |.| ...|::...:..||..||||:|:|..||.   :..|.|.:|||....           |:|
Frog  1318 EPEVLPHPKKCFFISQKRQVSVGEIVNGASLPH---FALHYPLSSFDALNKYTGGNSLVEPGLRS 1379

  Fly   569 IAWTAKDQLAGM---QQEEMQPQMPSQPPAVSKHSDTLFKVPMQPDGTAAGFGVFAAAAV--PPA 628
            |..|....:.|:   ::.|::|:........|..::||..:|:.|      ..|.....|  ||.
Frog  1380 IQETHGSAMFGIEKPEEREIEPEEQPNKQTFSLPTETLEPIPVVP------ISVLRPIMVPKPPP 1438

  Fly   629 SSIDGFSFVLPKSRAQEFQEQAPATQQRRAQEEAKHQALQVAIAAAKKREAELMAIHEAKVAEAE 693
            |.        ||....|  |......|...:|..|.|:.::..||.    |.:.|...|.|..|:
Frog  1439 SP--------PKPVFTE--EDIHLLAQDITEEIVKEQSFELIQAAT----AYISAARGAAVPIAD 1489

  Fly   694 RVRQQKLRE-----RQEQQRRQQQELEEQRQREQEKLQLEKERQLKLEQLFFVQQQEREAHKQTR 753
            .:....:.|     ..|:...::|.::|::.::.|:.:|::||:..|:|:...|.:
Frog  1490 TLLTDVISEISHRVAVEEVSSEKQRVKEEKLKKAEEARLKQEREKLLDQISLSQCK--------- 1545

  Fly   754 TLELYQEIFQDTLAEICQSEFM------SHSRACRSYESMLDSITRDLVERQM----EQSIYELG 808
              :|.:|:..|::..|...|..      .::|..|..|.:.|......:|.::    ..|::|:.
Frog  1546 --DLLKEVLTDSIYNISAEELKHAVQLDKNARISRCSEKVCDEYLSQFLEVEIFELARDSLHEMQ 1608

  Fly   809 VMRVCIRRWR-------KYRRTQQ----------EKDTLFNQLP---------------LSFGAE 841
            .....::|||       |.||..:          ..|.|...||               |:.|..
Frog  1609 YYSKYLQRWREVLAVRKKLRRQMRGFPAAPGSVSRNDKLKALLPSAALHGAHLGFAKGFLNLGHA 1673

  Fly   842 NPEGV------VNKRSMEDSLRLSRRYR------LGEPCDYGKLLA-GLEEHSWLKLDLWH---V 890
            ...||      .::..:...:::...::      ...|.....|:| .||  ||.....|.   :
Frog  1674 GKIGVSFTSFHQSREKIFHQMKVQHFFQKLLCDAAWTPLQLPSLIAQNLE--SWKDCIFWKLVLL 1736

  Fly   891 LDKCLPVAQPGA--RRFYKLLISLSGGQEGLQLNCDLDRGLLQQP-QSPDARFVDGGYIRGFSQG 952
            |.:...:.:|.:  ..:.|...|.:|||........:|..:|... :|.:.|.|........:||
Frog  1737 LPETSEIPEPSSILSEWLKAKFSWTGGQTSDTEQQSVDTLVLYSSLESQNGRPVRVNVCVKVAQG 1801

  Fly   953 IGLSVMKIRDDDHDWKATDLAEANGIICLIGLDDIRLLPD--------RLKPLLQASRCH---DV 1006
             .|:..::...:   ...||...:|:|.|:...|..:..|        :||.||||....   .:
Frog  1802 -PLTTSEMEQVE---TKRDLLGTSGLILLLPPVDDSIEDDVYWLSALLQLKQLLQAKPFQPPIPL 1862

  Fly  1007 AVIVQHPA---NT-AFVQPDIPLQEL----CLRSFNIFRLRKSGNNRQRLMIALESAVKFLAKAT 1063
            .|:|  ||   || ..|:..:.|.:|    .:..:.||.|..|.::.|... .:.|||:||..:.
Frog  1863 GVLV--PAFGMNTMTKVEEGLNLADLVSNGLISEYEIFPLSGSLDDLQGTE-QVTSAVQFLLSSC 1924

  Fly  1064 ERKRVGHLHQVE-----TREYL---LVNLGSELFRRLKYAAEHDTAIRSDTQL---NPQRCVDLF 1117
            .       |.:|     .|:::   :.:..||.|.|       |...|...:|   :|...:||:
Frog  1925 P-------HTLELCSLPLRQFIEDGICSGFSEPFHR-------DMWERKKARLPSQDPAAIIDLY 1975

  Fly  1118 NEAVHRL-QLVAGEDLSD--WP--QF--PEELRVFVQPLPIESSLNTNRLEHFEPGWHLPERRQR 1175
            |..:..| .:::.|.|||  ||  :|  |....|    || .:|.|       .|| ||...::.
Frog  1976 NSVLAFLANVISSEQLSDISWPVTEFSCPNGTAV----LP-HTSWN-------HPG-HLAWLKKS 2027

  Fly  1176 IVQLLERCKLPKMPVLPRSSSLAEAQCQWVLDYAQISQQEDCVE--QIALQAIKILQYDTDDYLN 1238
            ::..    ::|:|...|:.:..... |..:|:|  |.|...|.:  .:.|..::||.....|.|:
Frog  2028 VLSF----QIPQMDKPPQGAPWLPV-CSMILEY--IDQICRCKQGLPVLLSEVQILLRHAYDKLH 2085

  Fly  1239 FVEYLAGERMQYILRQERNPPQGIVYNTKTLKRRFLSAWYYEFREPQIYEPVPAEE--------- 1294
               ..||.|..                                      |..||||
Frog  2086 ---TNAGGRYS--------------------------------------EEFPAEEFPWDDLLNL 2109

  Fly  1295 --NAQMLEKQPSSQAEVQQLDFDEITSKAEAVLKRFHQ--RQDERHTLRELNRSHKSRKRRDASD 1355
              |.::.:..||            :.|:....|:..|.  .||:   ||.|:.|:...:.| .|.
Frog  2110 CINHKLRDWDPS------------VNSEYSGSLEDIHVYFLQDD---LRNLSPSNLWERAR-MST 2158

  Fly  1356 HKHAMSSLVSALKAARSDYQGKSSAVCRLVAQMVEADQVKYQWTPNLTSLIDRKDASTRHQWRPH 1420
            |..|..:           |.|:|           ...::..|.|..|.|:....:.:..::   .
Frog  2159 HTDAQET-----------YDGRS-----------YRQRLPTQKTKMLASIRVSPEQNLENE---E 2198

  Fly  1421 VNHSTRHARKLPVQSISFLSR-------C---LAKKGEHAGLTSCVLSVKTRYAPKTLHGRELLI 1475
            :....:|..||.:|....|..       |   |.|..|...|.:....:...|.|:.|
Frog  2199 LGAEFKHINKLRLQLKQSLEAEREESKGCKEKLQKFLEEEALETSASPLLPMYLPEAL------- 2256

  Fly  1476 WRQSSMRPLLLPSSNLWTGV--------LSKRHYV--PRLRPAEED---EEVERRAV--PQLRIT 1525
                 :||...|::...:||        |....|:  |: ||.|.:   ..::|..:  ||||.|
Frog  2257 -----LRPQEKPTNRSHSGVHSSPLHMSLETALYISSPQ-RPVEHNMSSSPLQRAPIKTPQLRST 2315

  Fly  1526 --------KEQSEEEE--------------HQLQRRKDGSRLRNECSEFYL 1554
                    ::.|..|.              ::|:|..:.:|..|...|.:|
Frog  2316 ENIIHAASQDSSLSESLSASPLRPSLTDKLNELRRLINANRQENSALELHL 2366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xmas	NP_001356948.1	RRM_XMAS2	12..82	CDD:240903	11/63 (17%)
		SAC3_GANP	200..503	CDD:335312	146/302 (48%)
		DUF5401	<638..>827	CDD:340095	44/220 (20%)
mcm3ap	XP_004917948.2	NupH_GANP	6..290	CDD:407035
		NupH_GANP	343..>581	CDD:407035
		RRM_SF	809..880	CDD:418427	11/64 (17%)
		SAC3_GANP	1012..1306	CDD:397460	146/302 (48%)
		CID_GANP	1535..1605	CDD:407033	14/80 (18%)
		MCM3AP_GANP	1633..2371	CDD:407036	178/872 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1680
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593971at2759
OrthoFinder	1	1.000	-	-		FOG0003569
OrthoInspector	1	1.000	-	-		oto105245
Panther	1	1.100	-	-	LDO	PTHR12436
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2919
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110