DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut2 and HXT8

DIOPT Version :9

Sequence 1:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_012321.1	Gene:	HXT8 / 853216	SGDID:	S000003750	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	529	Identity:	128/529 - (24%)
Similarity:	218/529 - (41%)	Gaps:	97/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VTPPKVNGWTPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDILANEYDTIVTAG---Q 68
            |.|.|.......:.::||.:..|     |:..|                    :||...:|   |
Yeast    54 VVPEKPASAYATVSIMCLCMAFG-----GFMSG--------------------WDTGTISGFVNQ 93

  Fly    69 LDIL-------------WTS------IVSIYLIGGICGSCFSAVLCDKYGRKGCLVISSVLFVVS 114
            .|.|             :.|      ||||:.:|...|..|.:.|.|.|||...|:|..|:::|
Yeast    94 TDFLRRFGNYSHSKNTYYLSNVRTGLIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVYMV- 157

  Fly   115 GILFTWCRAAKSLEMLMTGRFLGGIASALIFTAQPMYLLESAPSELSGSVGVFTCIGVTGGILLA 179
            ||:.......|..:..: ||.:.||.:..|....||.:.|:||..:.|::.....:.||..|.|.
Yeast   158 GIVIQIASIDKWYQYFI-GRIIAGIGAGSISVLAPMLISETAPKHIRGTLLACWQLMVTFAIFLG 221

  Fly   180 QVATLSHLLGSERL-W--PYALSF-YSLLVMASLVLLWWFPESPRWLY------LHKRDSAASEK 234
            ..........|..: |  |..|.| ::::::..:..:   |||||:|.      ..|...|.|.|
Yeast   222 YCTNYGTKTYSNSVQWRVPLGLCFAWAIIMIGGMTFV---PESPRFLVQVGKIEQAKASFAKSNK 283

  Fly   235 ALLRLRGRNTEEEVHQELLEMKATLEAKSSSEVSSLCSVL-RNSELWLPLLLVCSFQATQQLSGI 298
            ..:      .:..|..|:..:.|.:||:.:...:|...:. |.::::..|.:.....:.|||:|.
Yeast   284 LSV------DDPAVVAEIDLLVAGVEAEEAMGTASWKELFSRKTKVFQRLTMTVMINSLQQLTGD 342

  Fly   299 NAIFFYSLSILTNAGFSDGAATWLNLGIGSFNLC-TSLLGPLLIRRFPRRPLMMISCSMCALALL 362
            |..|:|..:|..:.|.:|...|.:.|||.:|..| .||.....:.|  ||.|::.:.:|.|..::
Yeast   343 NYFFYYGTTIFKSVGMNDSFETSIVLGIVNFASCFFSLYSVDKLGR--RRCLLLGAATMTACMVI 405

  Fly   363 AMSLG---LFFLERSE---------STVLTYFCAAFILTFILGFQLGLGPIAYFIGSELLEDSPR 415
            ..|:|   |:...:||         :.|.|.|       :|..|....||:.|.|.||......|
Yeast   406 YASVGVTRLYPNGKSEPSSKGAGNCTIVFTCF-------YIFCFSCTWGPVCYVIISETFPLRVR 463

  Fly   416 PVAMSMGSLFSWIGNFLVGMCFPLLQSV---WSSFAFIPCMCVCIYCLLLTWRYLPETRGREPKD 477
            ...||:.:..:.:..||:|...|.:.|.   :..:.|:.|:....:.:..   ::|||:|...::
Yeast   464 SKCMSVATAANLLWGFLIGFFTPFITSAINFYYGYVFMGCLAFSYFYVFF---FVPETKGLTLEE 525

  Fly   478 VKLLMSQGL 486
            |..:...|:
Yeast   526 VDEMWMDGV 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	122/498 (24%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	107/416 (26%)
HXT8	NP_012321.1	Sugar_tr	69..530	CDD:395036	124/508 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840