DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut2 and VPS73

DIOPT Version :9

Sequence 1:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_011411.3	Gene:	VPS73 / 852774	SGDID:	S000003072	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	503	Identity:	141/503 - (28%)
Similarity:	232/503 - (46%)	Gaps:	63/503 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VVMHVTPPKVNGW--TPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDILANEYDTIVT 65
            ::.:|:.|:.|..  |..|....:..::| :|..||....||||.:::.       .:|:|..:.
Yeast    10 LLSNVSMPRQNKHKITKALCYAIIVASIG-SIQFGYHLSELNAPQQVLS-------CSEFDIPME 66

  Fly    66 AGQLDILWTS-----------------IVSIYLIGGICGSCFSAVLCDKYGRKGCLVISSVLFVV 113
            ....|..|..                 :.|::.||||.||.|:..|.:.||||...:|:..|.:|
Yeast    67 GYPYDRTWLGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIV 131

  Fly   114 -SGILFTWCRAAKSLEMLMTGRFLGGIASALIFTAQPMYLLESAPSELSGSVGVFTCIGVTGGIL 177
             |.|:|.    :.|...|:.||.|.||:...:....|:::.|.|||...|.:|..|.|.:..|:|
Yeast   132 GSLIIFN----SNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVL 192

  Fly   178 LAQVATLSHLLGSERLWPYALSFYSLLVMASLVLLWWF--PESPRWLYLHKRDSAASEKALLRLR 240
            |.|...|. |..|.| |.:.| |.|.|: |.|....||  .|||:||..|.|.:.| :.:|.:||
Yeast   193 LTQGIALP-LTDSYR-WRWIL-FGSFLI-AVLNFFMWFIVDESPKWLLAHGRVTDA-KLSLCKLR 252

  Fly   241 GRNTEEEVHQELLEMKATLEAKSS-SEVSSLCSVLRNSELWLPL-----------LLVCSFQATQ 293
            | .|.:|..||:.:.:..:|:... .|.::..|:..::.||..|           :.|..|  .|
Yeast   253 G-VTFDEAAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRDRTNVKSRHVITVLLF--GQ 314

  Fly   294 QLSGINAIFFYSLSILTNAGFSDGAATWLNLGIGSFNLCTSLLGPLLIRRFPRRPLMMISCSMCA 358
            |..|||:|..|...|::.  .....|..:|..|...|:..::|..|||...||:||:|.|..:.:
Yeast   315 QFCGINSIVLYGTKIISQ--LYPQHAIRINFFISMVNVLVTILVSLLIHSLPRKPLLMTSTVLVS 377

  Fly   359 LALLAMSLGLFFLERSESTVLTYFCAAFILTFILGFQLGLGPIAYFIGSELLEDSPRPVAMSMGS 423
            :....|.:.   :..::..:|..|  :||...:  |.:||.|:.:.|..|:.:.....:|...|:
Yeast   378 VTAFIMGIA---MNHNKMNLLIVF--SFIYMGV--FTMGLNPLPFIIMREVSKPQDMVLAQRYGT 435

  Fly   424 LFSWIGNFLVGMCFPLLQSVWSSFAFIPCMCVCIYCLLLTWRYLPETR 471
            :.:|:|.|::...||::..|.|.:.||....:........|:.:|||:
Yeast   436 ICNWVGTFIIAYTFPIIHDVLSGYVFIIFAIIACSISAFIWKKVPETK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	136/481 (28%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	121/404 (30%)
VPS73	NP_011411.3	MFS_GLUT_Class1_2_like	31..484	CDD:340915	136/482 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		mtm9155
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16872
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870