Protein Alignment sut2 and SLC2A4

DIOPT Version :9

• Sequence 1: NP_524732.1
• Gene: sut2 / 44269
• FlyBaseID: FBgn0028562
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_001033.1
• Gene: SLC2A4 / 6517
• HGNCID: 11009
• Length: 509
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 165/472 - (34%)
• Similarity: 246/472 - (52%)
• Gaps: 19/472 - (4%)

  Fly     9 PP--KVNGWTPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDILAN----EYDTIVTAG 67
            ||  :|.|   .|:|...:..|| ::..||..||:|||.::|::...:....    |..:.:..|
Human    15 PPQQRVTG---TLVLAVFSAVLG-SLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPG 75

  Fly    68 QLDILWTSIVSIYLIGGICGSCFSAVLCDKYGRKGCLVISSVLFVVSGILFTWCRAAKSLEMLMT 132
            .|..||...|:|:.:||:..|....::....|||..:::::||.|:.|.|.....||.|.|||:.
Human    76 TLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLIL 140

  Fly   133 GRFLGGIASALIFTAQPMYLLESAPSELSGSVGVFTCIGVTGGILLAQVATLSHLLGSERLWPYA 197
            ||||.|..|.|.....|||:.|.||:.|.|::|....:.:..|||:|||..|..|||:..|||..
Human   141 GRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLL 205

  Fly   198 LSFYSLLVMASLVLLWWFPESPRWLYLHKRDSAASEKALLRLRGRNTEEEVHQELLEMKATLEAK 262
            |....|..:..||||.:.|||||:||:.:.....:.|:|.||.|......|..||.:.|..||.:
Human   206 LGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERE 270

  Fly   263 SSSEVSSLCSVLRNSELWLPLLLVCSFQATQQLSGINAIFFYSLSILTNAGFSDGAATWLNLGIG 327
               ...||..:|.:.....||::....|.:||||||||:|:||.||...||.  |...:..:|.|
Human   271 ---RPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGV--GQPAYATIGAG 330

  Fly   328 SFNLCTSLLGPLLIRRFPRRPLMMIS-CSMCALALLAMSLGLFFLERSESTVLTYFCAAFILTFI 391
            ..|...:|:..||:.|..||.|.::. ..||..|:| |::.|..|||..:  ::|.....|..|:
Human   331 VVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAIL-MTVALLLLERVPA--MSYVSIVAIFGFV 392

  Fly   392 LGFQLGLGPIAYFIGSELLEDSPRPVAMSMGSLFSWIGNFLVGMCFPLLQSVWSSFAFIPCMCVC 456
            ..|::|.|||.:||.:||....|||.||::....:|..||::||.|..:......:.|:....:.
Human   393 AFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLL 457

  Fly   457 IYCLLLTWRYLPETRGR 473
            :...:.|:..:||||||
Human   458 LGFFIFTFLRVPETRGR 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	157/454 (35%)
		MFS	76..466	CDD:119392	138/390 (35%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	159/457 (35%)
		Monosaccharide binding. /evidence=ECO:0000250|UniProtKB:P11166	298..304		5/5 (100%)
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557	489..490

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144215
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	0.197	Inparanoid score	I2535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.900