Protein Alignment sut2 and SLC2A3

DIOPT Version :10

• Sequence 1: NP_524732.1
• Gene: sut2 / 44269
• FlyBaseID: FBgn0028562
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 154/463 - (33%)
• Similarity: 247/463 - (53%)
• Gaps: 8/463 - (1%)

  Fly    16 TPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDILANEYDTIVTAGQLDILWTSIVSIY 80
            ||.|:......|:| :...||..||:|||.:|||::....|.::.:...:...|..||:..|:|:
Human     7 TPALIFAITVATIG-SFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIF 70

  Fly    81 LIGGICGSCFSAVLCDKYGRKGCLVISSVLFVVSGILFTWCRAAKSLEMLMTGRFLGGIASALIF 145
            .:||:.||....:..:::||:..::|.::|.|..|.....|:.|||:|||:.||.:.|:...|..
Human    71 SVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCT 135

  Fly   146 TAQPMYLLESAPSELSGSVGVFTCIGVTGGILLAQVATLSHLLGSERLWPYALSFYSLLVMASLV 210
            ...|||:.|.:|:.|.|:.|....:|:..|||:||:..|..:||||.|||..|.|..|..:....
Human   136 GFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSA 200

  Fly   211 LLWWFPESPRWLYLHKRDSAASEKALLRLRGRNTEEEVHQELLEMKATLEAKSSSEVSSLCSVLR 275
            .|.:.|||||:|.:::::...:::.|.||.|   .::|.|::.|||......|..:..::..:.|
Human   201 ALPFCPESPRFLLINRKEEENAKQILQRLWG---TQDVSQDIQEMKDESARMSQEKQVTVLELFR 262

  Fly   276 NSELWLPLLLVCSFQATQQLSGINAIFFYSLSILTNAGFSDGAATWLNLGIGSFNLCTSLLGPLL 340
            .|....|:::....|.:||||||||:|:||..|..:||..:  ..:..:|.|..|...:::...|
Human   263 VSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQE--PIYATIGAGVVNTIFTVVSLFL 325

  Fly   341 IRRFPRRPLMMISCSMCALALLAMSLGLFFLERSESTVLTYFCAAFILTFILGFQLGLGPIAYFI 405
            :.|..||.|.||.....|.....|::.|  |.:.....:::.|...||.|:..|::|.|||.:||
Human   326 VERAGRRTLHMIGLGGMAFCSTLMTVSL--LLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFI 388

  Fly   406 GSELLEDSPRPVAMSMGSLFSWIGNFLVGMCFPLLQSVWSSFAFIPCMCVCIYCLLLTWRYLPET 470
            .:||....|||.||::....:|..|||||:.||.......::.||......|..|..|:..:|||
Human   389 VAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPET 453

  Fly   471 RGREPKDV 478
            |||..:|:
Human   454 RGRTFEDI 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	MFS_GLUT_Class1_2_like	23..473	CDD:340915	148/449 (33%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	148/451 (33%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		1/1 (100%)