DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut2 and SLC2A2

DIOPT Version :9

Sequence 1:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_000331.1	Gene:	SLC2A2 / 6514	HGNCID:	11006	Length:	524	Species:	Homo sapiens

Alignment Length:	506	Identity:	144/506 - (28%)
Similarity:	252/506 - (49%)	Gaps:	45/506 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VTPPKVNGWTPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDILA---------NEY-- 60
            :|..||.|   .|:...:|..|| :...||..||:|||.::|....:.:|.         |.|
Human     1 MTEDKVTG---TLVFTVITAVLG-SFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVI 61

  Fly    61 -----------------------DTIVTAGQLDILWTSIVSIYLIGGICGSCFSAVLCDKYGRKG 102
                                   :|:..|..:.:||:..||.:.:||:..|.|...|.|..||..
Human    62 NSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIK 126

  Fly   103 CLVISSVLFVVSGILFTWCRAAKSLEMLMTGRFLGGIASALIFTAQPMYLLESAPSELSGSVGVF 167
            .::::::|.:|..:|..:.:...|..:::.||.:.|:...||....|||:.|.||:.|.|::|.|
Human   127 AMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTF 191

  Fly   168 TCIGVTGGILLAQVATLSHLLGSERLWPYALSFYSLLVMASLVLLWWFPESPRWLYLHKRDSAAS 232
            ..:.:..|||::|:..|..:||:..||...|....:..:...:||::.|||||:||:...:...:
Human   192 HQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKA 256

  Fly   233 EKALLRLRGRNTEEEVHQELLEMKATLEAKSSSEVSSLCSVLRNSELWLPLLLVCSFQATQQLSG 297
            :::|.||||   .::|.:::.||:...|..||.:..|:..:..||....|:|:.......||.||
Human   257 KQSLKRLRG---YDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSG 318

  Fly   298 INAIFFYSLSILTNAGFSDGAATWLNLGIGSFNLCTSLLGPLLIRRFPRRPLMMISCSMCALALL 362
            ||.||:||.||...||.|  ...:..:|:|:.|:..:.:...|:.:..||.|.:|..|...:..:
Human   319 INGIFYYSTSIFQTAGIS--KPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAI 381

  Fly   363 AMSLGLFFLERSESTVLTYFCAAFILTFILGFQLGLGPIAYFIGSELLEDSPRPVAMSMGSLFSW 427
            .||:||..|  ::.:.::|.....|..|:..|::|.|||.:|:.:|.....|||.|:::.:..:|
Human   382 FMSVGLVLL--NKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNW 444

  Fly   428 IGNFLVGMCFPLLQSVWSSFAFIPCMCVCIYCLLLTWRYLPETRGREPKDV 478
            ..||:|.:||..:......:.|.....|.:...|.|:..:|||:|:..:::
Human   445 TCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEI 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	138/483 (29%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	117/389 (30%)
SLC2A2	NP_000331.1	Sugar_tr	14..499	CDD:278511	139/490 (28%)
		MFS	98..485	CDD:119392	117/393 (30%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	314..320		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144198
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	0.197	Inparanoid score	I2535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.900