DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut2 and SLC2A9

DIOPT Version :9

Sequence 1:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_011512158.1	Gene:	SLC2A9 / 56606	HGNCID:	13446	Length:	615	Species:	Homo sapiens

Alignment Length:	499	Identity:	142/499 - (28%)
Similarity:	222/499 - (44%)	Gaps:	50/499 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WTPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDILANEYDTIVTAGQLDILWTSIVSI 79
            |:..|::..|....|::...||...|:|||...||.:..:.....:...:....|.:||:..|||
Human    52 WSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSI 116

  Fly    80 YLIGGICGSCFSAVLCDKYGRKGCLVISSVLFVVSGILFTWCRAAKSLEMLMTGRFLGGIASALI 144
            :.|||:.|:....::....|||..|:.::...:.:.:|......|.:.|||:.|||:.||...:.
Human   117 FAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVA 181

  Fly   145 FTAQPMYLLESAPSELSGSVG----VFTCIGVTGGILLAQVATLSHLLGSERLWPYALSFYSLLV 205
            .:..||||.|.:|.|:.||:|    :|.||||..|.||.    |..|||.|..|||......:..
Human   182 LSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLG----LPELLGKESTWPYLFGVIVVPA 242

  Fly   206 MASLVLLWWFPESPRWLYLHKRDSAASEKALLRLRGRNTEEEVHQELLEMKATLEAKSSSEVSSL 270
            :..|:.|.:.|:|||:|.|.|.:.|.:.||.....|:   .:|.||:.|:.|....:.|..:.|:
Human   243 VVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGK---ADVSQEVEEVLAESRVQRSIRLVSV 304

  Fly   271 CSVLRNSELWLPLLLVCSFQATQQLSGINAIFFYSLSILTNAGFSDGAATWLNLGIGSFNLCTSL 335
            ..:||...:...::.|....|..||.|:|||:||:.||...||.......::.|..|......::
Human   305 LELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAV 369

  Fly   336 LGPLLIRRFPRRPLMMISCSMCALALLAMSLGLFF-------LERSESTVLTYFCAAFILTFILG 393
            ...|:|....||||::....:         :||||       ..:..:..:.|.....||..|..
Human   370 FSGLVIEHLGRRPLLIGGFGL---------MGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIAS 425

  Fly   394 FQLGLGPIAYFIGSELLEDSPRPVAMSMGSLFSWIGNFLVGMCFPLLQ---------SVWSSFAF 449
            |..|.|.|.:.:..|..:.|.||.|..:....:|:.||.||:.||.:|         .:...|..
Human   426 FCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQLLLLLLSLLRIQPGFKL 490

  Fly   450 IP----------CMCVCIYCLLLTWRYLPETRGREPKDVKLLMS 483
            .|          |...|  .:..||..||  ....|.:.:::||
Human   491 PPPPPPPKKNTHCKRSC--GISSTWNDLP--LSSSPGEHQVMMS 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	137/479 (29%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	122/419 (29%)
SLC2A9	XP_011512158.1	2A0115	48..462	CDD:273327	124/425 (29%)
SLC2A9	XP_011512158.1	MFS	61..466	CDD:119392	124/420 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	0.197	Inparanoid score	I2535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800