DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut2 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_112474.2	Gene:	Slc2a2 / 20526	MGIID:	1095438	Length:	523	Species:	Mus musculus

Alignment Length:	499	Identity:	142/499 - (28%)
Similarity:	244/499 - (48%)	Gaps:	54/499 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LTVTLGTTI--------PVGYFFGVLNAPAEIIKKWCQDIL--------------ANEYDTIVT- 65
            :|.||..|:        ..||..||:|||.|:|....:.:|              .|..||.:|
Mouse     6 ITGTLAFTVFTAVLSSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRKAAINYDVNGTDTPLTV 70

  Fly    66 ------------------AGQLDILWTSIVSIYLIGGICGSCFSAVLCDKYGRKGCLVISSVLFV 112
                              |..:.:||:..||.:.:||:..|.|...|.||.||...::.::.|.:
Mouse    71 TPAYTTPAPWDEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSL 135

  Fly   113 VSGILFTWCRAAKSLEMLMTGRFLGGIASALIFTAQPMYLLESAPSELSGSVGVFTCIGVTGGIL 177
            ...:|....:...:..:::.||.:.|:...||....|||:.|.||:.|.|::|....:.:..|||
Mouse   136 TGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGIL 200

  Fly   178 LAQVATLSHLLGSERLWPYALSFYSLLVMASLVLLWWFPESPRWLYLHKRDSAASEKALLRLRGR 242
            ::|:|.||.:||::..|...|...::..:...:||.:.|||||:||:...:...::|:|.||||
Mouse   201 ISQIAGLSFILGNQDHWHILLGLSAVPALLQCLLLLFCPESPRYLYIKLEEEVRAKKSLKRLRG- 264

  Fly   243 NTEEEVHQELLEMKATLEAKSSSEVSSLCSVLRNSELWLPLLLVCSFQATQQLSGINAIFFYSLS 307
              .|:|.:::.|||...|..|:.:..|:..:..::....|:|:.......||.||||.||:||.|
Mouse   265 --TEDVTKDINEMKKEKEEASTEQKVSVIQLFTDANYRQPILVALMLHMAQQFSGINGIFYYSTS 327

  Fly   308 ILTNAGFSDGAATWLNLGIGSFNLCTSLLGPLLIRRFPRRPLM---MISCSMCALALLAMSLGLF 369
            |...||.|.  ..:..:|:|:.|:..:.:..||:.:..||.|.   ||....|.   :.||:||.
Mouse   328 IFQTAGISQ--PVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLTGMIGMFFCT---IFMSVGLV 387

  Fly   370 FLERSESTVLTYFCAAFILTFILGFQLGLGPIAYFIGSELLEDSPRPVAMSMGSLFSWIGNFLVG 434
            .|::  ...::|.....|..|:..|::|.|||.:|:.:|.....|||.|:::.:..:|:.||::.
Mouse   388 LLDK--FAWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFVIA 450

  Fly   435 MCFPLLQSVWSSFAFIPCMCVCIYCLLLTWRYLPETRGREPKDV 478
            :||..:......:.|.....|.:...|.|:..:|||:|:..:::
Mouse   451 LCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKVPETKGKSFEEI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	141/492 (29%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	117/392 (30%)
Slc2a2	NP_112474.2	Sugar_tr	14..498	CDD:278511	138/491 (28%)
		MFS	90..484	CDD:119392	119/403 (30%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	313..319		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2506
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.890