DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut2 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_524732.1	Gene:	sut2 / 44269	FlyBaseID:	FBgn0028562	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus

Alignment Length:	524	Identity:	116/524 - (22%)
Similarity:	203/524 - (38%)	Gaps:	130/524 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GWTPLLMLICLTVTLGTTIPVGYFFGVLNAPAEIIKKWCQDIL----------ANE--------- 59
            ||:|...|......||:...|.:....:....:    |.|..|          ||.
Mouse    63 GWSPAEELNYTVPGLGSAGEVSFLSQCMRYEVD----WNQSTLDCVDPLSSLAANRSHLPLSPCE 123

  Fly    60 ----YDT----IVT--------AGQLDILWTSIVSIYLIGGICGSCFSAVLCDKYGRKGCLVISS 108
                |||    |||        :..|| |:.|:|:   :|...|:.....|.|::|||.||:::.
Mouse   124 HGWVYDTPGSSIVTEFNLVCAHSWMLD-LFQSLVN---VGFFIGAVGIGYLADRFGRKFCLLVTI 184

  Fly   109 VLFVVSGIL------FTWCRAAKSLEMLMTGRFLGGIASALIFTAQPMYLLESAPSELSGSVGVF 167
            ::..:||:|      :.|         ::..|||.|:.|...:....:.:.|........:||:.
Mouse   185 LINAISGVLMAISPNYAW---------MLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGIC 240

  Fly   168 TCIGVTGGILLAQVATLSHLLGSERLWPYALSFYSLLVMASLVLLWWFPESPRWLYLHKRDSAAS 232
            ..|..|.|:|:  :|.:::.|.:.|...:|:   :|.....|:..|..|||||||....:::.|.
Mouse   241 YQIAFTVGLLI--LAGVAYALPNWRWLQFAV---TLPNFCFLLYFWCIPESPRWLISQNKNAKAM 300

  Fly   233 E--KALLRLRGR-------------NTEEEVHQELLEMKATLEAKSSSEVSSLCSVLRNSELWLP 282
            :  |.:.:..|:             :|..:::...|::..|.:.:..:.: .:.:...:|.|:..
Mouse   301 KIIKHIAKKNGKSVPVSLQSLTADEDTGMKLNPSFLDLVRTPQIRKHTLI-LMYNWFTSSVLYQG 364

  Fly   283 LLLVCSFQATQQLSGINAI--FFYSLSILTNAGFSDGAATWLNLGIGSFNLCTSLLGPLLIRRFP 345
            |::      ...|:|.|..  ||||..:...|.|                     :..|.|.|..
Mouse   365 LIM------HMGLAGDNIYLDFFYSALVEFPAAF---------------------IIILTIDRIG 402

  Fly   346 RRPLMMISCSMCALALLAMSLGLFFLERSESTVLTYFCAAFILTFILGFQLGLGPIAY----FIG 406
            ||....:|..:...|.||   .:|..:..:...:|..|        || ::|: .|||    .:.
Mouse   403 RRYPWAVSNMVAGAACLA---SVFIPDDLQWLKITVAC--------LG-RMGI-TIAYEMVCLVN 454

  Fly   407 SELLEDSPRPVAMSMGSLFSWIGNFLVGMCFPLLQSVWSSFAFIPCMCVCIYC--LLLTWRYLPE 469
            :||.....|.:|:.:.|....||..:.......|..:|..|..:....|.:..  |:|   .|||
Mouse   455 AELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAGGLVL---LLPE 516

  Fly   470 TRGR 473
            |:|:
Mouse   517 TKGK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut2	NP_524732.1	Sugar_tr	23..473	CDD:278511	111/513 (22%)
sut2	NP_524732.1	MFS	76..466	CDD:119392	89/418 (21%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	116/524 (22%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	94/425 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326501at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920