DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut3 and SLC2A3

DIOPT Version :9

Sequence 1:	NP_524731.1	Gene:	sut3 / 44268	FlyBaseID:	FBgn0028561	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_008862.1	Gene:	SLC2A3 / 6515	HGNCID:	11007	Length:	496	Species:	Homo sapiens

Alignment Length:	468	Identity:	147/468 - (31%)
Similarity:	249/468 - (53%)	Gaps:	6/468 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GKQGWTCLLVLICVCITVGTVIPVGYAFGVMNAPSAFIRSWIMESVLERYSSRLGDSQMTIIMST 68
            |.|..|..|:......|:|: ...||..||:|||...|:.:|.:::.::.::...:..:|.:.|.
Human     2 GTQKVTPALIFAITVATIGS-FQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSL 65

  Fly    69 VVSIFLIGGMLGAPFAPIFSARLGRRGILTLSGLLLLVSCICQLFCRMANSIEMLLLGRLIGGLA 133
            .|:||.:|||:|:....:|..|.|||..:.:..||.:........|::|.|:|||:||||:.||.
Human    66 SVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLF 130

  Fly   134 AALIYATQPMYLVELAPAELSGSVGVFTCIGLTGGIVLGQVFSFDFLLGTEKLWPYALSGSAIFV 198
            ..|.....|||:.|::|..|.|:.|....:|:..||::.|:|..:|:||:|:|||..|..:.:..
Human   131 CGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPA 195

  Fly   199 LIGLAPIFWFPESPRFLM-SQGRREKARVTLMRL--RRDEGRVNAEMAEFEVSSTDEGQVTMKQV 260
            ::..|.:.:.|||||||: ::...|.|:..|.||  .:|..:...||.:.....:.|.|||:.::
Human   196 ILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLEL 260

  Fly   261 LCNSKLKLPLFIVCSFHFVQQMSGISAIWFYSIEIFTQSGFTAAVAMWLNFALGLLNFISALMGP 325
            ...|..:.|:.|.......||:|||:|:::||..||..:|....:  :.....|::|.|..::..
Human   261 FRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPI--YATIGAGVVNTIFTVVSL 323

  Fly   326 WLMRSFNRRLMMTISCLCSAIFLVLLVVGLELMSTIHEFSFTCIAFLSLYIITFNMGLGPTPYFI 390
            :|:....||.:..|.....|....|:.|.|.|....:..||.||..:.:::..|.:|.||.|:||
Human   324 FLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFI 388

  Fly   391 GSEIFETASRPSAMALGSFFNWLANFVLNMIFPTLNSATGPFVFLLCVVFCAYGFLLTYRYLPET 455
            .:|:|....||:|||:....||.:||::.::||:.....|.:||::...|.......|:..:|||
Human   389 VAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPET 453

  Fly   456 RNRDAKDVAQLME 468
            |.|..:|:.:..|
Human   454 RGRTFEDITRAFE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut3	NP_524731.1	Sugar_tr	28..466	CDD:278511	140/440 (32%)
sut3	NP_524731.1	MFS	66..451	CDD:119392	124/387 (32%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	140/446 (31%)
		Important for selectivity against fructose. /evidence=ECO:0000269\|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:26176916	280..286		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	0.197	Inparanoid score	I2535
Isobase	1	0.950	-	0	Normalized mean entropy	S1875
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750