DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sut3 and Slc2a8

DIOPT Version :9

Sequence 1:NP_524731.1 Gene:sut3 / 44268 FlyBaseID:FBgn0028561 Length:476 Species:Drosophila melanogaster
Sequence 2:NP_062361.1 Gene:Slc2a8 / 56017 MGIID:1860103 Length:477 Species:Mus musculus


Alignment Length:484 Identity:123/484 - (25%)
Similarity:200/484 - (41%) Gaps:92/484 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 GYAFGVMN---------APSAFIRSWIMESVLERYSSRLGDSQMTIIMSTVVSIFLIGGMLGAPF 83
            |:|.|..:         ||.|.               ||||:..:...:.|......||:||...
Mouse    41 GFALGYSSPAIPSLRRTAPPAL---------------RLGDNAASWFGAVVTLGAAAGGILGGWL 90

  Fly    84 APIFSARLGRRGILTLSGLLLLVSCICQL-FCRMANSIEMLLLGRLIGGLAAALIYATQPMYLVE 147
            ..    |.||:    ||.||..|..:... ....|..:.|||.|||:.|||..:.....|:|:.|
Mouse    91 LD----RAGRK----LSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISE 147

  Fly   148 LAPAELSGSVGVFTCIGL--TGGIVLGQVFSFDFLLGTEKLWPYALSGSAIFVLIGLAP------ 204
            :|...:.|.:|  :|:.|  ..||:|.      ::.|....|.:       ..::|..|      
Mouse   148 IAYPAVRGLLG--SCVQLMVVTGILLA------YVAGWVLEWRW-------LAVLGCVPPTLMLL 197

  Fly   205 -IFWFPESPRFLMSQGRREKARVTLMRL-RRDEG----RVNAEMAEFEVSSTDEGQVTMKQVLCN 263
             :.:.||:||||::|.:.::|...|..| ..:||    .|.||...|:::           :|..
Mouse   198 LMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLA-----------LLRR 251

  Fly   264 SKLKLPLFIVCSFHFVQQMSGISAIWFYSIEIFTQSG-----------------FTAAVAMWLNF 311
            ..:..||.|..|....||:||::||.||:..||.::.                 |||..|:.::.
Mouse   252 PGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDR 316

  Fly   312 A-LGLLNFISALMGPWLMRSFNRRLMMTISCLCSAIFLVLLVVGLELMSTIHEFSFTCIAFLSLY 375
            | ..||..:|.::..:.|.:|.....:|.|...::..:.|:.:..|.:......::..:..:.|:
Mouse   317 AGRRLLLALSGVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLF 381

  Fly   376 IITFNMGLGPTPYFIGSEIFETASRPSAMALGSFFNWLANFVLNMIFPTLNSATGPF-VFLLCVV 439
            |..|.:|.||.|:.:.||||....:..|..:....||...|::...|.::.....|: .|.|...
Mouse   382 IAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTAA 446

  Fly   440 FCAYGFLLTYRYLPETRNRDAKDVAQLME 468
            |||...|.|...:|||:.|..:.|....|
Mouse   447 FCALSVLFTLTVVPETKGRTLEQVTAHFE 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sut3NP_524731.1 Sugar_tr 28..466 CDD:278511 122/480 (25%)
MFS 66..451 CDD:119392 107/418 (26%)
Slc2a8NP_062361.1 Dileucine internalization motif. /evidence=ECO:0000269|PubMed:16723738 12..13
Sugar_tr 29..474 CDD:278511 122/481 (25%)
MFS 31..459 CDD:119392 117/466 (25%)
Monosaccharide binding. /evidence=ECO:0000250|UniProtKB:P11166 268..274 4/5 (80%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834259
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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