DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut3 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_524731.1	Gene:	sut3 / 44268	FlyBaseID:	FBgn0028561	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	136/502 - (27%)
Similarity:	228/502 - (45%)	Gaps:	71/502 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VCITVGTVI----PVGYAFGVMNAPSAFIRSWIMESVLERYSSRLG---DSQ------------- 61
            :..||.|.:    ..||..||:|||        .|.::..|...||   |.:
  Rat    10 LAFTVFTAVLGSFQFGYDIGVINAP--------QEVIISHYRHVLGVPLDDRRATINYDINGTDT 66

  Fly    62 ------------------------MTIIMSTVVSIFLIGGMLGAPFAPIFSARLGR------RGI 96
                                    :|::.|..||.|.:|||:.:.|......:|||      ...
  Rat    67 PLIVTPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANS 131

  Fly    97 LTLSGLLLLVSCICQLFCRMANSIEMLLLGRLIGGLAAALIYATQPMYLVELAPAELSGSVGVFT 161
            |:|:|.||: .|     .:...:..:::.||.:.||...||....|||:.|:||..|.|::|...
  Rat   132 LSLTGALLM-GC-----SKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLH 190

  Fly   162 CIGLTGGIVLGQVFSFDFLLGTEKLWPYALSGSAIFVLIGLAPIFWFPESPRFLMSQGRRE-KAR 225
            .:.|..||::.|:....|:||.:..|...|..||:..|:....:.:.|||||:|..:...| :|:
  Rat   191 QLALVTGILISQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYLKLEEEVRAK 255

  Fly   226 VTLMRLRRDEG---RVNAEMAEFEVSSTDEGQVTMKQVLCNSKLKLPLFIVCSFHFVQQMSGISA 287
            .:|.|||..|.   .:|....|.|.:||:: :|::.|:..:...:.|:.:....|..||.|||:.
  Rat   256 KSLKRLRGTEDVTKDINEMRKEKEEASTEQ-KVSVIQLFTDPNYRQPIVVALMLHLAQQFSGING 319

  Fly   288 IWFYSIEIFTQSGFTAAVAMWLNFALGLLNFISALMGPWLMRSFNRRLMMTISCLCSAIFLVLLV 352
            |::||..||..:|.:..|  :....:|.:|.|...:...|:....||.:.....:......|.:.
  Rat   320 IFYYSTSIFQTAGISQPV--YATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFMS 382

  Fly   353 VGLELMSTIHEFSFTCIAFLSLYIITFNMGLGPTPYFIGSEIFETASRPSAMALGSFFNWLANFV 417
            :||.|:......|:..:..:.|::..|.:|.||.|:|:.:|.|....||:|:||.:|.||:.||:
  Rat   383 LGLVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFI 447

  Fly   418 LNMIFPTLNSATGPFVFLLCVVFCAYGFLLTYRYLPETRNRDAKDVA 464
            :.:.|..:....||:||.|.........|.|:..:|||:.:...::|
  Rat   448 IALCFQYIADFLGPYVFFLFAGVVLIFTLFTFFKVPETKGKSFDEIA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut3	NP_524731.1	Sugar_tr	28..466	CDD:278511	133/487 (27%)
sut3	NP_524731.1	MFS	66..451	CDD:119392	116/394 (29%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	135/492 (27%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337946
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	0.113	Inparanoid score	I2429
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900