DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut3 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_524731.1	Gene:	sut3 / 44268	FlyBaseID:	FBgn0028561	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_620182.1	Gene:	Slc2a1 / 24778	RGDID:	3704	Length:	492	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	142/448 - (31%)
Similarity:	234/448 - (52%)	Gaps:	9/448 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GYAFGVMNAPSAFIRSWIMESVLERYSSRLGDSQMTIIMSTVVSIFLIGGMLGAPFAPIFSARLG 92
            ||..||:|||...|..:..::...||...:..:.:|.:.|..|:||.:|||:|:....:|..|.|
  Rat    27 GYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFG 91

  Fly    93 RRGILTLSGLLLLVSCICQLFCRMANSIEMLLLGRLIGGLAAALIYATQPMYLVELAPAELSGSV 157
            ||..:.:..||..||.:...|.::..|.|||:|||.|.|:...|.....|||:.|::|..|.|::
  Rat    92 RRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGAL 156

  Fly   158 GVFTCIGLTGGIVLGQVFSFDFLLGTEKLWPYALSGSAIFVLIGLAPIFWFPESPRFLM-SQGRR 221
            |....:|:..||::.|||..|.::|...|||..||...|..|:....:.:.|||||||: ::...
  Rat   157 GTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEE 221

  Fly   222 EKARVTLMRLR--RDEGRVNAEMAEFEVSSTDEGQVTMKQVLCNSKLKLPLFIVCSFHFVQQMSG 284
            .:|:..|.:||  .|..|...||.|.......|.:||:.::..:...:.|:.|.......||:||
  Rat   222 NRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSG 286

  Fly   285 ISAIWFYSIEIFTQSGFTAAVAMWLNFALGLLNFISALMGPWLMRSFNRRLMMTISCLCSAIFLV 349
            |:|:::||..||.::|....|  :.....|::|....::..:::....||.:..|.....|...|
  Rat   287 INAVFYYSTSIFEKAGVQQPV--YATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAV 349

  Fly   350 LLVVGLELMSTIHEFSFTCIAFLSLYIITFNMGLGPTPYFIGSEIFETASRPSAMALGSFFNWLA 414
            |:.:.|.|:..:...|:..|..:..::..|.:|.||.|:||.:|:|....||:|:|:..|.||.:
  Rat   350 LMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTS 414

  Fly   415 NFVLNMIFPTLNSATGPFVFLLCVVFCAYGFLLTYRYLPETRNRDAKDVAQLMENGFK 472
            ||::.|.|..:....||:||::..|.....|:.||..:|||:.|...::|    :||:
  Rat   415 NFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIA----SGFR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut3	NP_524731.1	Sugar_tr	28..466	CDD:278511	140/440 (32%)
sut3	NP_524731.1	MFS	66..451	CDD:119392	124/387 (32%)
Slc2a1	NP_620182.1	MFS_GLUT_Class1	14..458	CDD:340989	138/432 (32%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	0.113	Inparanoid score	I2429
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900