DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut3 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_524731.1	Gene:	sut3 / 44268	FlyBaseID:	FBgn0028561	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_112474.2	Gene:	Slc2a2 / 20526	MGIID:	1095438	Length:	523	Species:	Mus musculus

Alignment Length:	503	Identity:	137/503 - (27%)
Similarity:	230/503 - (45%)	Gaps:	72/503 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VCITVGTVI----PVGYAFGVMNAPSAFIRSWIMESVLERYSSRLG-----------------DS 60
            :..||.|.:    ..||..||:|||        .|.::..|...||                 |:
Mouse    10 LAFTVFTAVLSSFQFGYDIGVINAP--------QEVIISHYRHVLGVPLDDRKAAINYDVNGTDT 66

  Fly    61 QMTI------------------------IMSTVVSIFLIGGMLGAPFAPIFSARLGR------RG 95
            .:|:                        :.|..||.|.:|||:.:.|......:|||      ..
Mouse    67 PLTVTPAYTTPAPWDEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAAN 131

  Fly    96 ILTLSGLLLLVSCICQLFCRMANSIEMLLLGRLIGGLAAALIYATQPMYLVELAPAELSGSVGVF 160
            .|:|:|.||: .|     .:...:..:::.||.:.||...||....|||:.|:||..|.|::|..
Mouse   132 SLSLTGALLM-GC-----SKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTL 190

  Fly   161 TCIGLTGGIVLGQVFSFDFLLGTEKLWPYALSGSAIFVLIGLAPIFWFPESPRFLMSQGRRE-KA 224
            ..:.|..||::.|:....|:||.:..|...|..||:..|:....:.:.|||||:|..:...| :|
Mouse   191 HQLALVTGILISQIAGLSFILGNQDHWHILLGLSAVPALLQCLLLLFCPESPRYLYIKLEEEVRA 255

  Fly   225 RVTLMRLRRDEG---RVNAEMAEFEVSSTDEGQVTMKQVLCNSKLKLPLFIVCSFHFVQQMSGIS 286
            :.:|.|||..|.   .:|....|.|.:||:: :|::.|:..::..:.|:.:....|..||.|||:
Mouse   256 KKSLKRLRGTEDVTKDINEMKKEKEEASTEQ-KVSVIQLFTDANYRQPILVALMLHMAQQFSGIN 319

  Fly   287 AIWFYSIEIFTQSGFTAAVAMWLNFALGLLNFISALMGPWLMRSFNRRLMMTISCLCSAIFLVLL 351
            .|::||..||..:|.:..|  :....:|.:|.|...:...|:....||.:.....:......:.:
Mouse   320 GIFYYSTSIFQTAGISQPV--YATIGVGAINMIFTAVSVLLVEKAGRRTLFLTGMIGMFFCTIFM 382

  Fly   352 VVGLELMSTIHEFSFTCIAFLSLYIITFNMGLGPTPYFIGSEIFETASRPSAMALGSFFNWLANF 416
            .|||.|:......|:..:..:.|::..|.:|.||.|:|:.:|.|....||:|:||.:|.||:.||
Mouse   383 SVGLVLLDKFAWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNF 447

  Fly   417 VLNMIFPTLNSATGPFVFLLCVVFCAYGFLLTYRYLPETRNRDAKDVA 464
            |:.:.|..:....||:||.|.........|.|:..:|||:.:..:::|
Mouse   448 VIALCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKVPETKGKSFEEIA 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut3	NP_524731.1	Sugar_tr	28..466	CDD:278511	134/488 (27%)
sut3	NP_524731.1	MFS	66..451	CDD:119392	117/394 (30%)
Slc2a2	NP_112474.2	Sugar_tr	14..498	CDD:278511	136/499 (27%)
		MFS	90..484	CDD:119392	117/402 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	313..319		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2506
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900