DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sara and ZFYVE16

DIOPT Version :9

Sequence 1:	NP_524729.2	Gene:	Sara / 44263	FlyBaseID:	FBgn0026369	Length:	1343	Species:	Drosophila melanogaster
Sequence 2:	NP_001098721.2	Gene:	ZFYVE16 / 9765	HGNCID:	20756	Length:	1539	Species:	Homo sapiens

Alignment Length:	1362	Identity:	415/1362 - (30%)
Similarity:	636/1362 - (46%)	Gaps:	246/1362 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 NSLDDYRENVKSLQVDAQLPSYDWQTEAEHEDDIHKFSEQASKN----NGQTIVSSSESLTTSSC 142
            ||.|   ||.|       ||.:.:|   |.:..|.:.:::.||:    :...|..||.:|..||.
Human   318 NSRD---ENFK-------LPDFSFQ---EDKTVIKQSAQEDSKSLDLKDNDVIQDSSSALHVSSK 369

  Fly   143 STFSSGPSPVSNGSHSEELATPPEDEKTSEVQVEPKEQDQQPEQVKHEDQHQDQAVPPPTQSKQT 207
            ...||.....::||....|             :|.|.:.....|.:|:|..||..         |
Human   370 DVPSSLSCLPASGSMCGSL-------------IESKARGDFLPQHEHKDNIQDAV---------T 412

  Fly   208 V-EELAVGLSSISITASGTESQSLLPEEVTASSVLGQVLEELSEESSPSREPETEMTNGIDVPLA 271
            : ||:.   :|:.:.....:...||.:|...|.:|..::|.:.:...   :|:..:.....:...
Human   413 IHEEIQ---NSVVLGGEPFKENDLLKQEKCKSILLQSLIEGMEDRKI---DPDQTVIRAESLDGG 471

  Fly   272 NLPASVAE---------VPVPKE-MEQPVQT------EEEDVELPQEQHPRRSQPLTFCSTMDEI 320
            :..::|.|         ||...: .|..:.|      :.:|::........:|.||        |
Human   472 DTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPL--------I 528

  Fly   321 SDTELDSMLQEM------------DADD-----NQADDQQMPDDE-----KSCSASPVTEEESVR 363
            ||.|||:.|.|.            :.:|     ||.|.:.:.|..     .:..|..:.|...:.
Human   529 SDAELDAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGIN 593

  Fly   364 ILS---DEQETTSNDQMNVDNFSQASTVEFADLKQPESTPVTAMGEDVAS--SFSSTESDSLSG- 422
            |:.   |:|.|..|..    :..:.||:       |....:.....::.:  |.|...|.|:.|
Human   594 IICEIVDKQNTIENGL----SLGEKSTI-------PVQQGLPTSKSEITNQLSVSDINSQSVGGA 647

  Fly   423 --RKLDGEVEVDREHEDASLATDALETQEQRPQRPQTLNLNGCQAESSTPSQDENPEIQQETLQP 485
              ::|.......|..:|.: ..|..:|.|..|....|:....|..:|:.   |.........:..
Human   648 RPKQLFSLPSRTRSSKDLN-KPDVPDTIESEPSTADTVVPITCAIDSTA---DPQVSFNSNYIDI 708

  Fly   486 TEVREGAAGVGVIPGEDD-EESPIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIKR 549
            ....||.:.. |...||. .|:...|.:       .||:..|.||||:.|..||.||.|||..||
Human   709 ESNSEGGSSF-VTANEDSVPENTCKEGL-------VLGQKQPTWVPDSEAPNCMNCQVKFTFTKR 765

  Fly   550 RHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQANGLNSESAPGSALPPTPIRS 614
            ||||||||||.|.|||:::.:|:: .|.|:||||.||..:|:.||.. ...|..||.|
Human   766 RHHCRACGKVFCGVCCNRKCKLQY-LEKEARVCVVCYETISKAQAFE-RMMSPTGSNL------- 821

  Fly   615 PNPNNPMEYCSTIPPHRQVANSPGAPPPSVIVPVGVLKKTDGSSSNSSSSDGQKG--QRKRKSVM 677
              .:|..:.|:|:.|.::  |...:.|....:||..||:           .|.:|  .:::|.|.
Human   822 --KSNHSDECTTVQPPQE--NQTSSIPSPATLPVSALKQ-----------PGVEGLCSKEQKRVW 871

  Fly   678 FSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSIDT-----SSTL-- 735
            |:|||.|..|:|.|.:            || |||....:..:|.:.:.|.:::|     |:|:
Human   872 FADGILPNGEVADTTK------------LS-SGSKRCSEDFSPLSPDVPMTVNTVDHSHSTTVEK 923

  Fly   736 -----GLVA--QLFRGSIPPSAAAATLSATETSAGRSSS-----------QSQAQTSPRRKAESS 782
                 |.:.  ::.:..|....:...||....:.|..:|           :::..:||.....:|
Human   924 PNNETGDITRNEIIQSPISQVPSVEKLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSPTGVLVNS 988

  Fly   783 R-------NRKLPPNGDAQGC----YLPPEENGLPPICISSKEGGEVDYKVVRNDGS------LL 830
            .       :.:|..:.:...|    .||.:|:.|||:.::|.|.|.|  .||....|      ||
Human   989 NLPIASISDYRLLCDINKYVCNKISLLPNDEDSLPPLLVASGEKGSV--PVVEEHPSHEQIILLL 1051

  Fly   831 DRLQNETLKFIIKNNFFVLVKIVNMSCCMNRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVK 895
            :......:.|::..|..|.||.:..| ....|.  |:|:|||.:|..|:|||| :..|.::
Human  1052 EGESFHPVTFVLNANLLVNVKFIFYS-SDKYWY--FSTNGLHGLGQAEIIILL-LCLPNED---- 1108

  Fly   896 GEVAIPKDLFQHLYEIYVEAEHAR--SGTHELAFTSPRNANFLGSREHGGFIFIRPTYQCLQGVI 958
               .||||:|:....||.:|...:  .....:.||.    :||.|::||||:||.||:|.|..:.
Human  1109 ---TIPKDIFRLFITIYKDALKGKYIENLDNITFTE----SFLSSKDHGGFLFITPTFQKLDDLS 1166

  Fly   959 VPDNPYLVGVLIHRHEVPWAKVLPLRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVD 1023
            :|.||:|.|:||.:.|:|||||.|:||:|||||:|:.||.||.|:|||:.::|||..||:|.|||
Human  1167 LPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSIRGRKPLFGEIGHTIMNLLVD 1231

  Fly  1024 FRNYSYSLPAIRGLYIHMEDRQTTVIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQ 1088
            .|||.|:|..|..|.||||..::.:.||:.:..||:|.:|::::|:::...:||..||.||||:|
Human  1232 LRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLNSSNEHVISIGASFSTEADSHLVCIQ 1296

  Fly  1089 NINDDRSEMYSYSTQAINIQGQPRKITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKME 1153
            |..       .|.|||.:..|.|||:|||||.|.|.|||:|||...|.|||||||||||.|..|.
Human  1297 NDG-------IYETQANSATGHPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQITPETMN 1354

  Fly  1154 EVRQALRNQNDIDIVCGPIDATDDQSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWA 1218
            .:|.|||.|.|..|.||.:||. |..|.|.|.|||.....|.||.|.:|...:.|..:.::...|
Human  1355 GLRLALREQKDFKITCGKVDAV-DLREYVDICWVDAEEKGNKGVISSVDGISLQGFPSEKIKLEA 1418

  Fly  1219 SFNYSNTNYAIRLSDIYIIKC-EDWYATNGGNCEEIT---RIAEQLARSASMALLPLLDLLAAAG 1279
            .|.          :|..|:|| |.:|.....:...::   :.|:::|.:.|.||.|.|..|.:.|
Human  1419 DFE----------TDEKIVKCTEVFYFLKDQDLSILSTSYQFAKEIAMACSAALCPHLKTLKSNG 1473

  Fly  1280 INKLGLRATLDQDNVGYEAGARGSKLPPLYMNALDNHLIATLHGESSGIQEPIILELIFYIL 1341
            :||:|||.::|.|.|.::||:.|..||..|:|.||:.||..:||.:|....|:.:||:|:|:
Human  1474 MNKIGLRVSIDTDMVEFQAGSEGQLLPQHYLNDLDSALIPVIHGGTSNSSLPLEIELVFFII 1535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	39/66 (59%)
		SARA	614..650	CDD:288292	8/35 (23%)
		DUF3480	959..1321	CDD:288806	162/365 (44%)
ZFYVE16	NP_001098721.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..491		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..678		9/38 (24%)
		FYVE_endofin	738..804	CDD:277268	39/66 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..850		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..907		7/35 (20%)
		DUF3480	1167..1515	CDD:371829	162/365 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	332	1.000	Domainoid score	I1135
eggNOG	1	0.900	-	-		E1_KOG1841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1052
Isobase	1	0.950	-	0	Normalized mean entropy	S6349
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003142
OrthoInspector	1	1.000	-	-		otm40943
orthoMCL	1	0.900	-	-		OOG6_105532
Panther	1	1.100	-	-	LDO	PTHR46319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X2534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.800