Protein Alignment Sara and zfyve16

DIOPT Version :10

• Sequence 1: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Sequence 2: XP_005155592.1
• Gene: zfyve16 / 794689
• ZFINID: ZDB-GENE-091116-62
• Length: 1384
• Species: Danio rerio
• Alignment Length: 1532
• Identity: 460/1532 - (30%)
• Similarity: 692/1532 - (45%)
• Gaps: 358/1532 - (23%)

  Fly     5 DIDQVLDNLELSIAADEQLSRNAAAAAAAGAN----PGRFLGD----------------GASAS- 48
            |:|::||:.|||  |:|..|:.....:....:    ||||:.:                |.::.
Zfish    11 DLDKLLDDFELS--AEELESKPGTYVSPPCPDSTLIPGRFIPEQHTVPQTLPDVNALHYGLTSQS 73

  Fly    49 --------------ISGVGAGAGVS--GAAGVTPTPASGKSFVGVSQVFN-----------SLDD 86
                          ::||...:.|.  |.....| |...:|...|..:.|           |.:|
Zfish    74 IDSNQKDSYSNEWPLTGVDLLSSVDSRGIKSSAP-PCPDRSLKPVCDLVNDTGSANLQQADSQED 137

  Fly    87 YRE-------NVKSLQVDAQLPSYDWQTEAEHEDDIHKFSEQASKNN-----------GQTIVSS 133
            ::|       :.:.|.||.:.|  :..::..|.:.:.:.|| .:.|:           |:...||
Zfish   138 FKELDIPDVQSTEGLLVDFESP--EDLSKPSHSEILKRDSE-INCNSLSLLDVILPVVGEPYTSS 199

  Fly   134 SESL--TTSSCSTFSSGPSPVSNGSHSEELATPPEDE------KTSEVQVEPKEQDQ----QPEQ 186
            |.:|  |.|||...|:     |||.:....:...||:      .|:|..:....::.    ||:.
Zfish   200 SITLLETESSCPEASN-----SNGQNDRPWSQMDEDDVCNTCPSTTEENISAFSEEHAVSLQPDS 259

  Fly   187 VKHEDQHQDQAVPPPTQSKQTVEELAVGLSSISITASGTESQSLLPEEV------------TASS 239
            ...:.::.:.....||..|    |.::....::::..|:...:|.|::.            |.|:
Zfish   260 TSEDVRNPEDLTGSPTSEK----ESSLSCLPMAVSMCGSLVATLDPQKAAVVETKDEAELETKSA 320

  Fly   240 VLGQVLEELS--------------EESSPSREPETEMTNGIDVPLANLPASV------------- 277
            :  |..|||:              .:|||..|||.       |.:.:.||:.
Zfish   321 I--QEAEELTLPLEEPVPPFSSSRPDSSPEDEPEI-------VQIMSNPAAAGHYPERNFKRTLS 376

  Fly   278 -----------AEVPVPKEMEQPVQTEEEDVE---LPQEQHPRRSQPLTFCSTMDEISDTELDSM 328
                       |..|.|...|.|..:.|..:.   ||:..           .|:..::|.|||:.
Zfish   377 PTDKLTCRDLGASNPSPSYSESPNYSYEFGIANDYLPESD-----------QTVMMVTDEELDAF 430

  Fly   329 LQ------------EMDADD-------NQADDQQMPDDEKSCSASPVTEEESVRILSDEQETTSN 374
            |.            |..:||       |...|..:.::.:||........||    ...|....:
Zfish   431 LMGQGVKINPDAAVEKFSDDGFSEFNGNAERDGFLDEELQSCKVETFASPES----DGSQYLEES 491

  Fly   375 DQMNVDNFSQASTVEFADLKQ-----PESTPV---TAMGEDVASSFSSTESDSLSGRKLDGEVEV 431
            :..||.:.||.|:...||..|     ..::||   :....:..|::.......||.:.:....|.
Zfish   492 EGSNVSSSSQDSSPLRADSTQTITHETVTSPVEIQSVCSPNQESTYGGARPKQLSNQTVRPPSER 556

  Fly   432 DR-EHEDASLATDALETQEQRPQRPQTLNLNGCQAESSTPSQD----ENPEIQQ--------ETL 483
            .| .|.:|.:...|                ||.|.   :|:||    |.|..||        |..
Zfish   557 HRISHAEADVGGSA----------------NGSQV---SPNQDEINCEPPSYQQYDSSYGCDELS 602

  Fly   484 QPTEVREGAAGVGVIPGE--DDEESPIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTM 546
            :|..          .|||  :|.||.: :..|:.  ...||...|.||||:.|..||.|.||||.
Zfish   603 EPPP----------YPGEMLEDGESSV-DLSGHG--AEGLGSKQPPWVPDSEAPNCMNCMQKFTF 654

  Fly   547 IKRRHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQAN-GLNSESAPGSALPPT 610
            .||||||||||||.|:.||:::.||:: .:.|:||||.|::.:...||: .:.|.:.|
Zfish   655 TKRRHHCRACGKVYCASCCNRKCRLKY-LDKEARVCVICHVTIQRAQAHERMMSPTGP------- 711

  Fly   611 PIRSPNPNNPMEYCSTIPPHRQ--VANSPGAPPPSVIVPVGVLKKTDGSSSNSSSSDGQKGQRKR 673
               |||||.|.||||||||.:|  .|.:..:|||:|:|||.|||        ...:||  ..|::
Zfish   712 ---SPNPNIPSEYCSTIPPMQQARAAGTLNSPPPTVMVPVSVLK--------HPGNDG--FPREQ 763

  Fly   674 KSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSIDTSSTLGLV 738
            |.|.|:|||.|..|:|.|.:.    |..:||....|         :|.|.:||...|
Zfish   764 KHVWFADGILPNGEVADTTKL----SVQTRRSSQES---------SPVTPDPPAPDD-------- 807

  Fly   739 AQLFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAES-----------SRNRKLPPNGD 792
                  ..|.       ...|:..|||.|..:|...|.|....           .|:..|
Zfish   808 ------KFPD-------EREESVGGRSDSPVEASRPPVRGPWDYGLLCGVGNCVQRDASL----- 854

  Fly   793 AQGCYLPPEENGLPPICISSKEGGEVDYKVVRNDGS-----LLDRLQNETLKFIIKNNFFVLVKI 852
                 :|.:::||||:.|.:.|..|.|..|.....:     ||:....:.|.|::..|..|.|||
Zfish   855 -----VPEDDDGLPPLLIITGEEEEGDLLVEERPAACQILLLLEEGGPQPLTFVLNANLLVNVKI 914

  Fly   853 VNMSCCMNRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEH 917
            |.. |....|.|  :::||..:|..||:.::|.        :..|.::|:|:|.....||.:|:.
Zfish   915 VTY-CGKRCWCL--SSNGLQGVGQKELVFIIEC--------LPEENSLPRDVFNLYVSIYQDAQK 968

  Fly   918 ARSGTH--ELAFTSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKV 980
            .:...|  .:.||.    :||||::|||.:|...|:|.|:|:.:|...:|.||||.:.|||||||
Zfish   969 GKFIEHLGNVTFTD----SFLGSKDHGGVLFFTATFQPLEGLALPQVSFLCGVLIQKLEVPWAKV 1029

  Fly   981 LPLRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQ 1045
            .||||:|.|||:|..|||||:|:|.||||:.|...||:|.|.|.|||.||||.:..|.:|||...
Zfish  1030 FPLRLLLALGAKYSVYPCPLMSIRFRESVFKETGHTIMNLLTDLRNYQYSLPVVESLRVHMEMGN 1094

  Fly  1046 TTVIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQ 1110
            :.:.|||.|..:::|.:|::::|:::|...||..||.||||:||      |..||.|.|.:|.|:
Zfish  1095 SYIEIPKSRFNEMLKVVNSSNEHVISFGACFSTEADSHLVCIQN------EDGSYQTSANSIPGK 1153

  Fly  1111 PRKITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDAT 1175
            .|::|||||.|.|.|||:|||...|.|||||||||||.|..||.:|||||:|||..|.||..| :
Zfish  1154 TRRVTGASFVVFNGALKASSGFIAKSSIVEDGLMVQIPPETMEGLRQALRDQNDFQIPCGKTD-S 1217

  Fly  1176 DDQSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDI-YIIKC 1239
            ::..|.|:::|||....:|.||.||:|.:.::|:|::::.:.:.|.....  .||.::: |::|.
Zfish  1218 EETRENVNVRWVDWTAPVNAGVTSPVDGKSLEGVSSVKIQQDSEFEMDGR--TIRCTEVFYLLKS 1280

  Fly  1240 EDWYATNGGNCEEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARGSK 1304
            .|  .:.........:...::|.::..||.|.|.:|.|.|.|.|.||.:.|.|.|.|:||:.|..
Zfish  1281 SD--VSLPAILTSSAQFQREIATASCAALCPHLSVLMANGFNSLALRVSTDSDMVEYQAGSSGRL 1343

  Fly  1305 LPPLYMNALDNHLIATLHGESSGI-QEPIILELIFYI 1340
            ||..|||.||..||..:||.||.: .:.:.:|..|||
Zfish  1344 LPQKYMNDLDGALIPVIHGGSSCVPHQAMDMEFFFYI 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	37/66 (56%)
		SARA	614..650	CDD:463271	23/37 (62%)
		DUF3480	959..1321	CDD:463419	163/362 (45%)
zfyve16	XP_005155592.1	FYVE_endofin	630..696	CDD:277268	37/66 (56%)
		SARA	712..750	CDD:463271	23/37 (62%)
		Fer4_8	841..>885	CDD:473136	12/53 (23%)
		DUF3480	1008..1360	CDD:463419	163/362 (45%)