DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sara and plekhf2

DIOPT Version :9

Sequence 1:	NP_524729.2	Gene:	Sara / 44263	FlyBaseID:	FBgn0026369	Length:	1343	Species:	Drosophila melanogaster
Sequence 2:	NP_956538.1	Gene:	plekhf2 / 393214	ZFINID:	ZDB-GENE-040426-884	Length:	247	Species:	Danio rerio

Alignment Length:	209	Identity:	63/209 - (30%)
Similarity:	92/209 - (44%)	Gaps:	37/209 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 SLSGRKLDGE---VEVDREHEDAS---LATDAL-----ETQEQRPQRPQTLNLNGCQAESST-PS 471
            ::.||.|.||   .::.|:...|.   |..|.|     ..|:::..:...:.|     ||.| .:
Zfish    30 AIPGRVLIGEGVLTKLCRKRPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPL-----ESVTIDT 89

  Fly   472 QDENPEIQQETLQPTEVREGAAGVGVIPGEDDEESPIYEAVGYSDPHANLGKVP-----PIWVPD 531
            .::..|::...|..|..:..|........:.:..|.|.:.|  ||.....||.|     .:||||
Zfish    90 VEDEGELRNGWLIKTPTKSFAVYAATATEKSEWMSHINKCV--SDLLEKSGKSPTGEHAAVWVPD 152

  Fly   532 NMAGQCMQCQQ-KFTMIKRRHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQAN 595
            :.|..||:||: |||.:.||||||.||.|:|..|..::|.|...:....|||..||..||
Zfish   153 SEATVCMRCQKMKFTPVNRRHHCRKCGFVVCGPCSEKKFLLPSQSSKPVRVCEFCYKQLS----- 212

  Fly   596 GLNSESAPGSALPP 609
                   .|:.|||
Zfish   213 -------TGATLPP 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	33/72 (46%)
		SARA	614..650	CDD:288292
		DUF3480	959..1321	CDD:288806
plekhf2	NP_956538.1	PH_Phafin2-like	7..129	CDD:269927	21/103 (20%)
		PH	39..131	CDD:278594	18/98 (18%)
		FYVE_PKHF2	148..211	CDD:277294	30/62 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..247		4/7 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030