Protein Alignment Sara and Zfyve9

DIOPT Version :10

• Sequence 1: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Sequence 2: NP_001101422.1
• Gene: Zfyve9 / 313477
• RGDID: 1310856
• Length: 1398
• Species: Rattus norvegicus
• Alignment Length: 1465
• Identity: 461/1465 - (31%)
• Similarity: 682/1465 - (46%)
• Gaps: 294/1465 - (20%)

  Fly     1 MDLVDIDQVLDNLELSIAADEQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGVSGAAGVT 65
            :|.:.||      |.::|.|:.:.||.                ......|.|..|....|:....
  Rat   100 IDTMWID------ENAVAEDQLIKRNY----------------NQDDQFSAVEVGEEKRGSLTCL 142

  Fly    66 PTPASGKSFVGVSQVFNSLDDYRENVKSLQVDAQ----------LPSYDWQTEAE-HEDDIHKFS 119
            |...:    |.|..|.::.|.     ::||.|.|          :.|:....:.| .:.|...||
  Rat   143 PDEKN----VLVVAVMHNCDK-----RTLQSDLQDCNNYNSQSLMDSFSCSLDNETRQTDQFSFS 198

  Fly   120 EQASKNNGQTIVSSSESLTTSS---------CSTFSSGPSPVSNGSH---SEELATPPEDEKTSE 172
            ...|...|.......::|....         |:..::..:.:|:.|.   :|.:...|.....:.
  Rat   199 MNGSAEKGINSEKQMDALNKPKSERDSLNHLCAASANSATSISSSSQLKDNENVGRDPSTSTATS 263

  Fly   173 VQVEPKE-QDQQPEQVKHEDQHQDQAVPPPTQSKQTVEELAVGLSSISITASGTE--SQSLLPEE 234
            :.:...: .|..|...|.||...|:.:.....|.:|  :|.   ||.|.:.|..|  :::...||
  Rat   264 LAINTSQGMDGGPAIKKQEDYMPDEDLSGANSSSRT--DLG---SSNSFSHSREELLTKTEPAEE 323

  Fly   235 VTASSVLGQVLE----------------ELSEESSPSREPETEMTNGIDVPLANLPASVAEVPVP 283
            .||...|...|.                |.|.:...|.|..|:...|.|....:..::..
  Rat   324 RTAEDPLPSGLSLNLKPDTPALCGRDNCEPSSDCLVSSETRTDGDGGKDSQTTHWDSAKL----- 383

  Fly   284 KEMEQPVQTEEEDVELPQEQHPRRSQPLTFCSTMDEISDTELD---SMLQEMDADD--------- 336
            .|::....:||..|.| |...|...|....|..|   :|::||   :.|.|.:..|
  Rat   384 NEVDDRQGSEENQVVL-QISQPEDPQSAGECVRM---ADSDLDFKGTCLNESEGYDFSTVSDAPA 444

  Fly   337 -----NQADD------------QQMPDDEKSCSASPVTEEESVRILSDEQETTSNDQMNVDNFSQ 384
                 |..|.            :.:|..|.|.:.....||......|:..|...|:....:....
  Rat   445 ANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNLYEQRGNENTEGNGLLL 509

  Fly   385 ASTVEFADLKQPESTPVTAMGEDVASSFSSTESDSLSGRKLDGEVEVDREHEDASLATDALETQE 449
            .||             .|.|.::...:|.| :..|:.|:.         ..:.|:|.:.::....
  Rat   510 NST-------------GTIMKKNYLHNFCS-QIPSVLGQS---------SPKIANLQSISVPFGG 551

  Fly   450 QRPQRPQTLNL-----------NGCQAESSTPSQDENPEIQQETL-QPTEVREGAAGVGVIPGED 502
            .||::|..|.|           |...|.:...|:::|..:.:..| :.:.|...:|.:|.|...|
  Rat   552 ARPKQPSNLKLQIPKPLSDHLQNDLPANNGNNSKNKNDILGKAKLGENSAVSACSATLGNISVTD 616

  Fly   503 --DEESPIYEA-------------------------VGYSDPHANLGKVPPIWVPDNMAGQCMQC 540
              .|....:||                         :....|...||:|.|:||||:.|..||:|
  Rat   617 TNGEHLESFEADISSRPCLALSPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKC 681

  Fly   541 QQKFTMIKRRHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQA--NGLNSESAP 603
            :.:||..||||||||||||.|:.|||.:.:|.:....|:||||.|:.:|...||  |.:::.|
  Rat   682 EARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASS-- 744

  Fly   604 GSALPPTPIRSPNPNNPMEYCSTIPPHRQVANSPGA---PPPSVIVPVGVLKKTDGSSSNSSSSD 665
                     :|||||||.||||||||.:| |.:.||   |||:|:|||||||........
  Rat   745 ---------QSPNPNNPAEYCSTIPPLQQ-AQASGALSSPPPTVMVPVGVLKHPGTEVPQ----- 794

  Fly   666 GQKGQRKRKSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGS-GAGQKPPTPATEEP-PRS 728
                .|:::.|.|:|||.|..|:|..       :|.:..|.|.:|: .....|..|....| |..
  Rat   795 ----PREQRRVWFADGILPNGEVADA-------AKLTMNGTSSAGTLAVSHDPVKPVATSPLPAE 848

  Fly   729 IDTSSTLGLVAQLFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRKLPPNGDA 793
            .|.|        ||.|||             |..|                        .|.|.|
  Rat   849 ADVS--------LFSGSI-------------TQVG------------------------SPVGSA 868

  Fly   794 QGCYLPPEENGLPPICISSKEGGEVDYKVVRNDG--SLLDRLQN---ETLKFIIKNNFFVLVKIV 853
            ..  |.||: |||||.||:  |.:.||.|.....  |::.:|::   :.|.|::..|...:||||
  Rat   869 MN--LIPED-GLPPILIST--GVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIV 928

  Fly   854 NMSCCMNRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEA-EH 917
            |.   :||....|||.|:|.:|..|::|||:.        :..|..:|||:|.|..::|.:| ..
  Rat   929 NY---VNRKCWCFTTKGMHAVGQSEIVILLQC--------LPDEKCLPKDIFNHFVQLYRDALAG 982

  Fly   918 ARSGTHELAFTSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLP 982
            :..|:...:|.|   .:||||:|||||:::..|:|.||.:::|..|||.|:||.:.|.|||||.|
  Rat   983 SVVGSLGHSFFS---QSFLGSKEHGGFLYMTSTHQSLQDLLLPTPPYLFGILIQKWETPWAKVFP 1044

  Fly   983 LRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTT 1047
            :||:|||||:||.|||||.|||.|:.::||...||:|.|.|||||.|:||.::||.:.||.|:|:
  Rat  1045 IRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPGVQGLVVDMEVRKTS 1109

  Fly  1048 VIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPR 1112
            :.||..|..:::||:|.:::|:||....|::.||.||||:|  |||.    :|.||||:|..|||
  Rat  1110 IKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQ--NDDG----NYQTQAISIHNQPR 1168

  Fly  1113 KITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDD 1177
            |:|||||||.:.|||||||...|.||||||:||||....|:.:|||||...|..|.||..||.|.
  Rat  1169 KVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDP 1233

  Fly  1178 QSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDW 1242
            |.:| .|:|||:::.:|.||.||||.:.|:.|:|:::...:  .|......||.::::.::.:|
  Rat  1234 QEQI-HIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGS--EYKANGKVIRWTEVFFLENDD- 1294

  Fly  1243 YATNGGNCEEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARGSKLPP 1307
            :.|...:..:.:|:.|.:|::..:||.|.|.||...|:.|||||.|||.|.|||:||:.|..||.
  Rat  1295 HRTCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPS 1359

  Fly  1308 LYMNALDNHLIATLHGESSGIQE-PIILELIFYIL 1341
            .||..||:.|:..:||.:..:.| |:.:|||||||
  Rat  1360 QYMKDLDSALVPVIHGGACQLSEGPVGIELIFYIL 1394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	36/66 (55%)
		SARA	614..650	CDD:463271	26/38 (68%)
		DUF3480	959..1321	CDD:463419	173/361 (48%)
Zfyve9	NP_001101422.1	FYVE_endofin	663..730	CDD:277268	36/66 (55%)
		SARA	746..784	CDD:463271	26/38 (68%)
		DUF3480	1021..1373	CDD:463419	173/361 (48%)