DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sara and Zfyve9

DIOPT Version :9

Sequence 1:NP_524729.2 Gene:Sara / 44263 FlyBaseID:FBgn0026369 Length:1343 Species:Drosophila melanogaster
Sequence 2:NP_001101422.1 Gene:Zfyve9 / 313477 RGDID:1310856 Length:1398 Species:Rattus norvegicus


Alignment Length:1465 Identity:461/1465 - (31%)
Similarity:682/1465 - (46%) Gaps:294/1465 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDLVDIDQVLDNLELSIAADEQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGVSGAAGVT 65
            :|.:.||      |.::|.|:.:.||.                ......|.|..|....|:....
  Rat   100 IDTMWID------ENAVAEDQLIKRNY----------------NQDDQFSAVEVGEEKRGSLTCL 142

  Fly    66 PTPASGKSFVGVSQVFNSLDDYRENVKSLQVDAQ----------LPSYDWQTEAE-HEDDIHKFS 119
            |...:    |.|..|.::.|.     ::||.|.|          :.|:....:.| .:.|...||
  Rat   143 PDEKN----VLVVAVMHNCDK-----RTLQSDLQDCNNYNSQSLMDSFSCSLDNETRQTDQFSFS 198

  Fly   120 EQASKNNGQTIVSSSESLTTSS---------CSTFSSGPSPVSNGSH---SEELATPPEDEKTSE 172
            ...|...|.......::|....         |:..::..:.:|:.|.   :|.:...|.....:.
  Rat   199 MNGSAEKGINSEKQMDALNKPKSERDSLNHLCAASANSATSISSSSQLKDNENVGRDPSTSTATS 263

  Fly   173 VQVEPKE-QDQQPEQVKHEDQHQDQAVPPPTQSKQTVEELAVGLSSISITASGTE--SQSLLPEE 234
            :.:...: .|..|...|.||...|:.:.....|.:|  :|.   ||.|.:.|..|  :::...||
  Rat   264 LAINTSQGMDGGPAIKKQEDYMPDEDLSGANSSSRT--DLG---SSNSFSHSREELLTKTEPAEE 323

  Fly   235 VTASSVLGQVLE----------------ELSEESSPSREPETEMTNGIDVPLANLPASVAEVPVP 283
            .||...|...|.                |.|.:...|.|..|:...|.|....:..::..     
  Rat   324 RTAEDPLPSGLSLNLKPDTPALCGRDNCEPSSDCLVSSETRTDGDGGKDSQTTHWDSAKL----- 383

  Fly   284 KEMEQPVQTEEEDVELPQEQHPRRSQPLTFCSTMDEISDTELD---SMLQEMDADD--------- 336
            .|::....:||..|.| |...|...|....|..|   :|::||   :.|.|.:..|         
  Rat   384 NEVDDRQGSEENQVVL-QISQPEDPQSAGECVRM---ADSDLDFKGTCLNESEGYDFSTVSDAPA 444

  Fly   337 -----NQADD------------QQMPDDEKSCSASPVTEEESVRILSDEQETTSNDQMNVDNFSQ 384
                 |..|.            :.:|..|.|.:.....||......|:..|...|:....:....
  Rat   445 ANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNLYEQRGNENTEGNGLLL 509

  Fly   385 ASTVEFADLKQPESTPVTAMGEDVASSFSSTESDSLSGRKLDGEVEVDREHEDASLATDALETQE 449
            .||             .|.|.::...:|.| :..|:.|:.         ..:.|:|.:.::....
  Rat   510 NST-------------GTIMKKNYLHNFCS-QIPSVLGQS---------SPKIANLQSISVPFGG 551

  Fly   450 QRPQRPQTLNL-----------NGCQAESSTPSQDENPEIQQETL-QPTEVREGAAGVGVIPGED 502
            .||::|..|.|           |...|.:...|:::|..:.:..| :.:.|...:|.:|.|...|
  Rat   552 ARPKQPSNLKLQIPKPLSDHLQNDLPANNGNNSKNKNDILGKAKLGENSAVSACSATLGNISVTD 616

  Fly   503 --DEESPIYEA-------------------------VGYSDPHANLGKVPPIWVPDNMAGQCMQC 540
              .|....:||                         :....|...||:|.|:||||:.|..||:|
  Rat   617 TNGEHLESFEADISSRPCLALSPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKC 681

  Fly   541 QQKFTMIKRRHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQA--NGLNSESAP 603
            :.:||..||||||||||||.|:.|||.:.:|.:....|:||||.|:.:|...||  |.:::.|  
  Rat   682 EARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASS-- 744

  Fly   604 GSALPPTPIRSPNPNNPMEYCSTIPPHRQVANSPGA---PPPSVIVPVGVLKKTDGSSSNSSSSD 665
                     :|||||||.||||||||.:| |.:.||   |||:|:|||||||........     
  Rat   745 ---------QSPNPNNPAEYCSTIPPLQQ-AQASGALSSPPPTVMVPVGVLKHPGTEVPQ----- 794

  Fly   666 GQKGQRKRKSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGS-GAGQKPPTPATEEP-PRS 728
                .|:::.|.|:|||.|..|:|..       :|.:..|.|.:|: .....|..|....| |..
  Rat   795 ----PREQRRVWFADGILPNGEVADA-------AKLTMNGTSSAGTLAVSHDPVKPVATSPLPAE 848

  Fly   729 IDTSSTLGLVAQLFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRKLPPNGDA 793
            .|.|        ||.|||             |..|                        .|.|.|
  Rat   849 ADVS--------LFSGSI-------------TQVG------------------------SPVGSA 868

  Fly   794 QGCYLPPEENGLPPICISSKEGGEVDYKVVRNDG--SLLDRLQN---ETLKFIIKNNFFVLVKIV 853
            ..  |.||: |||||.||:  |.:.||.|.....  |::.:|::   :.|.|::..|...:||||
  Rat   869 MN--LIPED-GLPPILIST--GVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIV 928

  Fly   854 NMSCCMNRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEA-EH 917
            |.   :||....|||.|:|.:|..|::|||:.        :..|..:|||:|.|..::|.:| ..
  Rat   929 NY---VNRKCWCFTTKGMHAVGQSEIVILLQC--------LPDEKCLPKDIFNHFVQLYRDALAG 982

  Fly   918 ARSGTHELAFTSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLP 982
            :..|:...:|.|   .:||||:|||||:::..|:|.||.:::|..|||.|:||.:.|.|||||.|
  Rat   983 SVVGSLGHSFFS---QSFLGSKEHGGFLYMTSTHQSLQDLLLPTPPYLFGILIQKWETPWAKVFP 1044

  Fly   983 LRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTT 1047
            :||:|||||:||.|||||.|||.|:.::||...||:|.|.|||||.|:||.::||.:.||.|:|:
  Rat  1045 IRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPGVQGLVVDMEVRKTS 1109

  Fly  1048 VIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPR 1112
            :.||..|..:::||:|.:::|:||....|::.||.||||:|  |||.    :|.||||:|..|||
  Rat  1110 IKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQ--NDDG----NYQTQAISIHNQPR 1168

  Fly  1113 KITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDD 1177
            |:|||||||.:.|||||||...|.||||||:||||....|:.:|||||...|..|.||..||.|.
  Rat  1169 KVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDP 1233

  Fly  1178 QSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDW 1242
            |.:| .|:|||:::.:|.||.||||.:.|:.|:|:::...:  .|......||.::::.::.:| 
  Rat  1234 QEQI-HIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGS--EYKANGKVIRWTEVFFLENDD- 1294

  Fly  1243 YATNGGNCEEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARGSKLPP 1307
            :.|...:..:.:|:.|.:|::..:||.|.|.||...|:.|||||.|||.|.|||:||:.|..||.
  Rat  1295 HRTCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPS 1359

  Fly  1308 LYMNALDNHLIATLHGESSGIQE-PIILELIFYIL 1341
            .||..||:.|:..:||.:..:.| |:.:|||||||
  Rat  1360 QYMKDLDSALVPVIHGGACQLSEGPVGIELIFYIL 1394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SaraNP_524729.2 FYVE_endofin 522..589 CDD:277268 36/66 (55%)
SARA 614..650 CDD:288292 26/38 (68%)
DUF3480 959..1321 CDD:288806 173/361 (48%)
Zfyve9NP_001101422.1 FYVE_endofin 663..730 CDD:277268 36/66 (55%)
SARA 746..784 CDD:402839 26/38 (68%)
DUF3480 1021..1373 CDD:403258 173/361 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166352793
Domainoid 1 1.000 316 1.000 Domainoid score I1236
eggNOG 1 0.900 - - E1_KOG1841
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 550 1.000 Inparanoid score I1096
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003142
OrthoInspector 1 1.000 - - otm45079
orthoMCL 1 0.900 - - OOG6_105532
Panther 1 1.100 - - O PTHR46319
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2534
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.750

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